Lipid peroxidation induced by the Cu,Zn‐superoxide dismutase and hydrogen peroxide system

Kwon, Oh Bin; Kang, Jung Hoon

doi:10.1080/15216549900201703

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…This result was not surprising because participants with serum HLD-C concentration ≥1.2 mmol/L had significantly higher plasma copper concentrations compared to participants with HDL-C <1.2 mmol/L in the current study, and a positive association between copper and HDL-C concentrations has been reported in previous studies ( 36 ). Cu-SOD and H 2 O 2 system induces lipid peroxidation ( 13 ). It has been reported that HDL is more susceptible to copper-induced oxidation than LDL when copper concentration is high ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…Despite being essential, excessive copper may mediate the formation of excessive damaging reactive oxygen species (ROS) via Haber-Weiss and Fenton-like reactions ( 11 ), which has been reported as a trigger for insulin resistance ( 12 ). The Cu-Superoxide dismutase (SOD) and hydrogen peroxide (H 2 O 2 ) system may induce lipid peroxidation ( 13 ), which is closely associated with diabetes ( 14 ). In addition, excess copper has been reported to reduce the relative abundance of short-chain fatty acid producing bacteria and increase the relative abundance of Corynebacterium , which collectively may promote metabolic inflammation and poor glucose control ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

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The Association Between Plasma Copper Concentration and Prevalence of Diabetes in Chinese Adults With Hypertension

Zhixin

Chen

et al. 2022

Front. Public Health

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ObjectiveThe relationship between plasma copper concentration and prevalence of diabetes in adults with hypertension is unclear. We aimed to determine the association between plasma copper concentration and prevalence of diabetes in Chinese adults with hypertension.MethodsA total of 2,579 participants (697 cases and 1,882 controls) was included in this cross-sectional study. Plasma copper concentrations were determined by inductively coupled plasma mass spectrometry. Multivariable logistic regression model was used to determine the association between plasma copper concentration and prevalence of diabetes.ResultsAccording to the logistic regression analyses, the adjusted OR for the prevalence of diabetes in participants with plasma copper concentration ≥109.4 μg/dL was 1.26 (1.00, 1.58) compared with those with plasma copper concentration <109.4 μg/dL (P = 0.048). The association was no longer significant following further adjusting for serum high-density lipoprotein cholesterol (HDL-C) concentration as a potential confounder. Stratified analyses demonstrated that serum HDL-C concentration significantly modified the association between plasma copper concentration and prevalence of diabetes (P-interaction = 0.043). In the strata of serum HDL-C concentration ≥1.2 mmol/L, a 56% increased prevalence of diabetes was observed in participants with plasma copper concentration ≥109.4 μg/dL compared with those with plasma copper concentration <109.4 μg/dL (P = 0.008). No significant relationship between plasma copper concentration and prevalence of diabetes was found in other strata.ConclusionOur findings suggested that high plasma copper concentration (≥109.4 μg/dL) was associated with increased prevalence of diabetes in Chinese hypertensive adults with serum HDL-C concentration ≥1.2 mmol/L.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association Between Plasma Copper Concentration and Prevalence of Diabetes in Chinese Adults With Hypertension

Zhixin

Chen

et al. 2022

Front. Public Health

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“…The relationship between Cu levels and lipid profile could be because of Cu on catalase and glutathione peroxidase, two enzymes that reduce hydrogen peroxidase and modulate oxidative stress and redox-mediated responses [ 93 ]. High serum Cu level inhibits glutathione reductase and reduces glutathione production, thus, altering lipid metabolism [ 94 , 95 ]. Furthermore, SOD activity is decreased with Cu deficiency which consequently increases the synthesis of hydroxyl free radicals that have a central link to atherosclerosis [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

et al. 2021

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Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional disturbances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn) and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the association between CMR factors and the status of Zn and Cu, in addition to Zn/Cu ratio. A total of 575 Qatari men and women aged 18 years and older were obtained from Qatar Biobank. Plasma levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric data and CMR factors were determined using standard methods. Adjusted associations between trace minerals and CMR were estimated by logistic regression. Partial correlation was performed to test the strength of the associations. Zn was not strongly correlated (p-value ˃ 0.01) or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated positively with body mass index (BMI) (0.23; p ˂ 0.001), pulse rate (PR) (0.18; p ˂ 0.001), total cholesterol (0.13; p = 0.01), and high-density lipoproteins (HDL) (0.27; p ˂ 0.001); and negatively with diastolic blood pressure (DBP) (−0.13; p = 0.01). High plasma Cu significantly decreased the risk of metabolic syndrome (MetS) (0.121; p ˂ 0.001). Furthermore, Zn/Cu ratio positively correlated with waist circumference (0.13; p = 0.01), systolic blood pressure (0.13; p ˂ 0.01), and DBP (0.14; p ˂ 0.01); and negatively with BMI (−0.19; p ˂ 0.001), PR (−0.17; p ˂ 0.001), and HDL (−0.27; p ˂ 0.001). High Zn/Cu ratio increased the prevalence of low HDL (4.508; p ˂ 0.001) and MetS (5.570; p ˂ 0.01). These findings suggest that high plasma Cu levels are associated with a protective effect on DBP, HDL and MetS and that high plasma Zn/Cu ratio is associated with the risk of having low HDL and MetS.

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“…On the other hand, copper also affects catalase and glutathione peroxidase (GSH Px) activity. Excessive copper also produces excessive copper chelate, indirectly inhibiting GSH reductase and reducing GSH production, affecting lipid metabolism [35,36].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Copper and Serum Lipids in Adults

Song

Wang

et al. 2018

Ann Nutr Metab

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Background: As an essential trace element, copper has been considered to play an important role in lipid metabolism. However, the associations of serum copper with lipid concentration and dyslipidemia are still controversial. Methods: We used the 2011–2014 National Health and Nutrition Examination Survey to examine the relationship between serum copper and lipid concentration among participants aged 20 years and older. Multivariate linear regression was conducted to estimate the differences in the level of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol. Logistic regression was conducted to examine the association between serum copper and the risk of dyslipidemia. Results: A total of 2,678 subjects were eligible for our analyses. The multivariable adjusted average differences (95% CIs) comparing the highest to the lowest copper tertile were 8.42 (1.45–15.38) mg/dL for TC, and 2.96 (0.02–5.90) mg/dL for HDL cholesterol. Compared with the lowest tertile of serum copper, participants had significantly higher risks of High-TC dyslipidemia (OR 1.46; 95% CI 1.02–2.08) in tertile 3 and High-LDL cholesterol dyslipidemia (OR 1.48; 95% CI 1.03–2.14) in tertile 2 after adjusting for covariates. In the stratified analyses, we found that the copper-dyslipidemia association was statistically significant in women and subjects younger than 45 years of age. Conclusion: High serum copper was associated with elevated serum concentrations of TC and HDL cholesterol, and was associated with increased risks of High-TC and High-LDL cholesterol dyslipidemia. However, the real association between serum copper and serum lipids should be verified in larger prospective cohort studies in future.

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Lipid peroxidation induced by the Cu,Zn‐superoxide dismutase and hydrogen peroxide system

Cited by 8 publications

References 15 publications

The Association Between Plasma Copper Concentration and Prevalence of Diabetes in Chinese Adults With Hypertension

The Association Between Plasma Copper Concentration and Prevalence of Diabetes in Chinese Adults With Hypertension

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

Association between Serum Copper and Serum Lipids in Adults

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