Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species

Kale, Manisha; Rathore, Nisha; John, Sheila; Bhatnagar, Deepak

doi:10.1016/s0378-4274(98)00399-3

Cited by 362 publications

(201 citation statements)

References 17 publications

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“…Interestingly, this mode is similar to pyrethroid toxicity in mammals. Because the mammalian sodium channel ortholog (e.g., rat brain IIA) is insensitive to pyrethroids (23), toxicity in mammals can occur through a secondary mode of action related to glutathione depletion and oxidative damage (24,25).…”

Section: Discussion Pyrethroid Resistance Varies Across Species Groupmentioning

confidence: 99%

Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aquatic crustacean, Hyalella azteca

Weston

Poynton

Wellborn

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

142

153

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Use of pesticides can have substantial nonlethal impacts on nontarget species, including driving evolutionary change, often with unknown consequences for species, ecosystems, and society. Hyalella azteca, a species complex of North American freshwater amphipods, is widely used for toxicity testing of water and sediment and has frequently shown toxicity due to pyrethroid pesticides. We demonstrate that 10 populations, 3 from laboratory cultures and 7 from California water bodies, differed by at least 550-fold in sensitivity to pyrethroids. The populations sorted into four phylogenetic groups consistent with species-level divergence. By sequencing the primary pyrethroid target site, the voltage-gated sodium channel, we show that point mutations and their spread in natural populations were responsible for differences in pyrethroid sensitivity. At least one population had both mutant and WT alleles, suggesting ongoing evolution of resistance. Although nonresistant H. azteca were susceptible to the typical neurotoxic effects of pyrethroids, gene expression analysis suggests the mode of action in resistant H. azteca was not neurotoxicity but was oxidative stress sustained only at considerably higher pyrethroid concentrations. The finding that a nontarget aquatic species has acquired resistance to pesticides used only on terrestrial pests is troubling evidence of the impact of chronic pesticide transport from land-based applications into aquatic systems. Our findings have farreaching implications for continued uncritical use of H. azteca as a principal species for monitoring and environmental policy decisions.

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Section: Discussion Pyrethroid Resistance Varies Across Species Groupmentioning

confidence: 99%

Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aquatic crustacean, Hyalella azteca

Weston

Poynton

Wellborn

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

142

153

View full text Add to dashboard Cite

show abstract

“…In these studies, oxidative stress markers and other biochemical parameters [7,13,22,27,31], and changes in these parameters upon the administration of detoxifying substances have been investigated [8,14,15,24,45]. However, no previous studies related to effectiveness of propolis against acute cypermethrin exposure exist.…”

Section: Discussionmentioning

confidence: 99%

“…These changes may either be directly caused by cypermethrin, or may develop upon the degradation and conversion of the free radicals generated by cypermethrin into less harmful metabolites. Previous studies [13,15,22] report cypermethrin causes changes in oxidative stress markers.…”

Section: Administration Of Cypermethrin Alonementioning

confidence: 92%

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

et al. 2008

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“…AChE inactivation may have resulted from either amino acid residue and/or membrane lipid oxidation (Ballinger et al, 2005). For instance, the AChE deactivation in rat erythrocytes by pyrethroid was correlated with the LPO status (Kale et al, 1999). Moreover, AChE inhibition in the arginine-treated rats could be prevented by the pretreatment with vitamins E and C (Wyse et al, 2004).…”

Section: Neurotoxic Effectmentioning

confidence: 99%

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

2006

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Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species

Cited by 362 publications

References 17 publications

Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aquatic crustacean, Hyalella azteca

Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aquatic crustacean, Hyalella azteca

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

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