Lipid Profile in Neonates and its Relation with Birth Weight and Gestational Age

Ramaraj, Savitha Mysore; Bharath, A. P.; Sanjay, Kalra

doi:10.1007/s12098-014-1661-7

Cited by 8 publications

(9 citation statements)

References 5 publications

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“…In addition, Ramaraj et al studied the entire lipid profile in AGA and SGA neonates, and they found that total cholesterol and LDL were significantly lower in SGA neonates (p < 0.05) which was in accordance with our results. 21,22 Regarding the correlation between the maternal serum lipid profile and the neonatal birth weight, it had been previously shown that the maternal concentration of TG in the third trimester is a stronger predictor of birth weight than glucose parameters. 23 Ghiasi et al found a positive correlation between the maternal serum TG level and the neonatal crown-heel length, as well as the birth weight.…”

Section: Discussionmentioning

confidence: 99%

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Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Abdel-Hamid

abdellatif

Ahmed³

et al. 2020

Am J Perinatol

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Objective Maternal malnutrition with disturbed lipid metabolism during pregnancy may affect the fetal lipid profile. We aimed to detect the relation between maternal and neonatal serum lipid profile, as well as to detect the serum lipid profile difference between small for gestational age (SGA) infants and appropriate for gestational age (AGA) infants to disclose the impact of maternal malnutrition on birth weight. Study Design A cross-sectional study was conducted on 150 pregnant women coming to the labor room. Before delivery, maternal serum levels of high-density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides (TGs), and total cholesterol were assessed, then after delivery, cord blood samples were taken for assessment of the neonatal lipid profile. Birth weights were measured, then the neonates were divided into SGA and AGA groups. Results Serum levels of LDL, TGs, and total cholesterol in the SGA infants were lower than that in the AGA infants. A positive correlation between maternal and neonatal serum TGs levels was found. Besides, there was a positive correlation between birth weight and maternal serum levels of LDL, TGs, and total cholesterol. Conclusion Maternal serum lipid profile could be an indicator of the neonatal serum lipid profile and birth weight. Key Points

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Abdel-Hamid

abdellatif

Ahmed³

et al. 2020

Am J Perinatol

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“…From the lipid profiles obtained in this study and based on evidence from international studies, like Adamkin 19 , Ghaemi et al 22 Ramaraj et al 23 , it is identified that these PT can be considered as at risk for cardiovascular impairment and development of MS throughout their lives.…”

mentioning

confidence: 76%

“…High triglyceride concentrations in PT increase the risk of developing cardiovascular diseases in the future; therefore, we must invest in actions that promote adequate nutrition for these children from birth to minimize the risks of future chronic diseases 23 . Moreover, this evidence indicates that during the follow-up of this group in the first years of life, the evolution of the lipid profile should be followed, since at 2 years of age the child will have the cholesterol levels he or she will maintain in the first 10 years of life 24 .…”

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confidence: 99%

Growth and biochemical markers of preterm newborns up to six months of corrected age

Barreto

Balbo

Rover

et al. 2018

J. Hum. Growth Dev.

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Growth and biochemical markers of preterm newborns up to six months of corrected age AbstractIntroduction: Due to advances in recent decades in maternalfoetal and neonatal medicine, a greater survival of preterm infants with progressively smaller birth weight and gestational age is observed, increasing the risk of future morbidities on those infants. Among these morbidities, alterations in growth and metabolism are found.Objective: To analyze the evolution of the growth and the metabolic profile of preterm infants' cohort from birth at six months of corrected age (CA). Methods:A descriptive and prospective study with a sample of 107 mothers and 115 preterm infants at birth and 72 preterm infants and 68 mothers at the end of followup. Growth (body weight, height, cephalic perimeter) was evaluated at six time points. Plasma concentrations of cholesterol, triglycerides, glucose and insulin of premature infants were assessed during three periods, from birth to 6 months of CA. Comparative analysis of the initial sample and the sample that finished the follow-up was used in chi-square family tests. To Evaluate the growth over the 6-month period by using repeated measurements.Results: Sociodemographic variables and maternal biochemical profile without statistical differences in the comparison of the mothers of the initial sample with those who completed the follow-up. Linear growth of preterm infants at six months of CA, however without recovery of growth. Plasma concentrations of triglycerides (birth = 48.1, 6 months = 151.1) and cholesterol (birth = 82.7, 6 months = 139.9) increased during the evaluations. Glycaemia remained stable (birth 80.4, 6 months = 83.3) and insulin decreased from 11.0 to 4.2. Conclusion:Growth of preterm infants, although linear, was lower than expected for age. Lipid profiles presented an ascending curve from birth onward. Therefore, this group is prone to delayed growth and to developing cardiovascular changes throughout life.Keywords: premature infant, growth, lipids, blood glicose, insulin. Corresponding author:clausviera@gmail.com Suggested citation: Barreto GMS, Balbo SL, Rover MS, Toso BRGO, Oliveira HR, Vieira CS. Growth and biochemical markers of preterm newborns up to six months of corrected age.

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“…[ 8 ] The average lipid parameters reported from the Western population in the neonates and from Indian populations are widely different. The data from one Indian study shows that the average total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides measured on day 3 or 4 were (total cholesterol 103.92 ± 47.79 mg/dl, triglycerides 187.62 ± 144.44 mg/dl, HDL-cholesterol 23.35 ± 11.41 mg/dl, and LDL-cholesterol 51.70 ± 23.03 mg/dl)[ 9 ] is nearly twice as higher as measured from a similar Western population measured just after birth (total cholesterol 53.9 ± 14.6 mg/dl, triglycerides 29.5 ± 16.0 mg/dl, HDL-cholesterol 21.9 ± 6.3 mg/dl, and LDL-cholesterol 26.2 ± 10.1 mg/dl). [ 10 ] Similar trends were also noted while comparing another Indian population data versus an Western population data.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile in Infant

Kumar¹,

Pandit²,

Chatterjee³

et al. 2021

Indian Journal of Endocrinology and Metabolism

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Introduction: Alteration in lipid parameters at birth has a strong association with the development of cardiovascular disease in later life. Material and Methods: Sixty-one infants below the age of 6 months underwent evaluation of lipid parameters. The infants studied were categorized into two groups of ≤4 and >4 weeks of age, wherein their lipid parameters were compared. Results: The normal distribution of lipid parameters of infants <6 months was generated. The mean total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol was 126.2 ± 26.5, 149.1 ± 48.6, 40.7 ± 14.6, and 69.4 ± 19.4 mg/dl, respectively. The total cholesterol and LDL-cholesterol measured in ≤4 and >4 weeks of age groups were statistically not different (total cholesterol 125.0 ± 30.1 mg/dl vs 127.4 ± 23.4 mg/dl, P = 0.727, and LDL-cholesterol 66.0 ± 19.2 mg/dl vs 75.4 ± 21.2 mg/dl, P = 0.780). However, the HDL-cholesterol and triglycerides measured at ≤4 weeks versus >4 weeks age groups were statistically different (HDL-cholesterol 44.9 ± 17.2 mg/dl vs 36.9 ± 10.8 mg/dl, P = 0.031, and triglyceride 147.4 ± 60.2 mg/dl vs 186.5 ± 75.7 mg/dl, P = 0.030). Conclusion: The mean lipid parameters were significantly more atherogenic compared to the Western population. Triglyceride levels and HDL-cholesterol levels change significantly after 4 weeks of age compared to that observed before 4 weeks of age.

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Lipid Profile in Neonates and its Relation with Birth Weight and Gestational Age

Cited by 8 publications

References 5 publications

Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Growth and biochemical markers of preterm newborns up to six months of corrected age

Lipid Profile in Infant

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