Lipid Profiles and Cardiovascular Risk in Patients with Oral Lichen Planus

Abstract

Background: It has been reported that dyslipidemia prevalence and cardiovascular disease risk were increased in subjects with oral lichen planus diagnose. On the other hand, so far, there is no available data on the topic of cardiovascular risk (CVR) in subjects with oral lichen planus (OLP). The main aim of this study, due to lack of any other study covering this topic, was to investigate lipid profile and assess CVR in patients with OLP. Materials and Methods: To create a routine lipid profile, we collected triglyceride serum levels, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol from 63 OLP patients and 63 healthy people representing control subjects. For every patient their individual cardiovascular risk was measured. Results: In comparison with the tested control subjects, patients with OLP had all parameters of the lipid profile elevated, with no differences of statistical importance. Furthermore, the experimental (OLP) and control groups shared similar mean values of the lipid profile parameters. Conclusions: The association of OLP with cardiovascular risk was not established and further studies with more subjects involved are required to validate this connection.

Foot Osteomyelitis Caused by Multidrug- and Extensively Drug-Resistant Gram-Negative Bacteria

“…The average age of our study participants (56.81 years) -higher than that reported by Rahmani et al (16) (49.92 years) and lower than that reported by Radic et al (7) (62.66 years) -was included in the assessment of OLP prevalence worldwide (patients' age range 50-60 years) (5).…”

“…A case-control study showed that LP patients, especially those with mucosal involvement, had a higher incidence of metabolic syndrome, which was associated with CVD risk (9). According to previous research, OLP patients have a more impaired lipid metabolism than those with LP or healthy controls (7,10,11). However, there is insufficient evidence to esta blish the CVD risk in patients with OLP.…”

“…Studies have shown that the lipid profile, particularly in the initial stages of T cell receptor stimulation, has an impact on signaling receptors and lymphocyte activation. Both high levels of cholesterol and TGs are major causes of hyperlipidemia (7). Moreover, malignancy has been associated with changes in the lipid profile because of the key role that lipids play in maintaining cell membrane integrity (8).…”

“…It is well known that OLP is recognized as a potentially malignant oral condition with a greater potential for malignant change than normal oral mucosa (7). A number of patients develop oral carcinoma on initial clinical keratosis and atrophy, although the overall transformation rate of OLP counts for 0.05% in ten years (7).…”

Hypertension in oral lichen planus: A systematic review and meta‐analysis

“…It has been recently demonstrated, based on evidence, that OLP is significantly associated with emotional disorders, especially depression, anxiety, and stress (De Porras‐Carrique et al, 2021), autoimmune diseases such as hypothyroidism and diabetes (De Porras‐Carrique et al, 2022), and liver diseases that predispose to the development of hepatocellular carcinoma, such as hepatitis B and C, liver cirrhosis and steatohepatitis (González‐Moles et al, 2020). Some primary‐level studies – case series – show that patients with OLP may also develop hypertension (Aguirre‐Urizar et al, 2020; Conrotto et al, 2018; Kragelund et al, 2009; Radic et al, 2022) which is relevant because of the serious health related complications, including cardiovascular disease and renal impairment (Oparil et al, 2018). However, despite the potential association of hypertension in patients with OLP, there are no focused systematic reviews and meta‐analyses available.…”