Lipid Screening in Childhood and Adolescence for Detection of Multifactorial Dyslipidemia

Lozano, Paula; Henrikson, Nora B.; Morrison, Caitlin C; Dunn, John; Nguyen, Matt; Blasi, Paula R.; Whitlock, Evelyn P

doi:10.1001/jama.2016.6423

Cited by 84 publications

(39 citation statements)

References 39 publications

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“…However, this issue should be carefully considered from multiple perspectives, including cost, benefit, and the harm of taking blood samples from healthy children and adolescents. According to the United States Preventive Services Task Force, the current evidence is insufficient to assess the usefulness of screening for lipid disorders in children and adolescents [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study

et al. 2018

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BackgroundThe triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood.MethodsThe Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986. We followed up 272 participants who completed health examinations at the age of 16 and 35 years. We excluded 27 participants with adolescent hypertension, defined as those whose blood pressures were above the age- and sex-specific 95th percentiles of the Korean population, and finally analysed 245 participants. We defined high and low TG/HDL-C ratio groups according to the age- and sex-specific 75th percentile of the TG/HDL-C ratio (1.04 for boys and 0.81 for girls) of the Korean population. Adult hypertension was defined by a systolic/diastolic blood pressure ≥ 140/90 mmHg or by taking antihypertensive medication at the age of 35 years. Logistic regression analysis was performed to evaluate the association between adolescent TG/HDL-C ratio and adult hypertension after adjusting for age at follow-up, sex, baseline systolic blood pressure, waist circumference, and total cholesterol and fasting glucose levels.ResultsDuring the 20-year follow-up, 11 (18.3%) individuals developed hypertension in the high TG/HDL-C ratio group and 10 (5.4%) individuals developed hypertension in the low TG/HDL-C ratio group. The adjusted odds ratio for incident hypertension in the high TG/HDL-C ratio group, compared with the low TG/HDL-C ratio group, was 3.40 (95% confidence interval 1.24–9.31).ConclusionsHigh TG/HDL-C ratio in adolescence is associated with hypertension in early adulthood.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0861-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study

et al. 2018

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“…Dyslipidemia in studied children was defined as an abnormal lipid profile value in at least one of: LDL-cholesterol (≥ 130 mg/dL), total cholesterol (TC) (≥ 200 mg/dL), HDL-cholesterol (< 40 mg/dL) and/or triglycerides (TG) (in children 0-9 years ≥ 100 mg/dL, and in those aged 10-19yrs ≥ 130 mg/dL) [38][39][40].…”

Section: Blood Collectionmentioning

confidence: 99%

A Case-Control Study of Salivary Redox Homeostasis in Hypertensive Children. Can Salivary Uric Acid be a Marker of Hypertension?

Maciejczyk

Taranta-Janusz

Wasilewska

et al. 2020

JCM

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Oxidative stress plays a critical role in the pathogenesis of hypertension; however, there are no data on salivary redox homeostasis and salivary gland function in children with hypertension. A total of 53 children with hypertension and age-and sex-matched controls were classified for the study. The antioxidant barrier and oxidative/nitrosative stress were evaluated in non-stimulated (NWS) and stimulated (SWS) whole saliva, plasma, and erythrocytes, with Student's t-test and Mann-Whitney U-test used for statistical analysis. We demonstrated that the activities of superoxide dismutase, catalase, and peroxidase were significantly higher in NWS, SWS, and erythrocytes of children with hypertension, similar to oxidative damage in proteins (advanced glycation end products) and lipids (malondialdehyde) as well as nitrosative stress markers (peroxynitrite and nitrotyrosine). The level of uric acid (UA) was significantly higher in NWS, SWS, and plasma of children with hypertension. UA concentration in SWS correlated positively with systolic and diastolic blood pressure and UA content in plasma. This parameter differentiates children with hypertension from healthy controls (AUC = 0.98) with a high degree of sensitivity (94%) and specificity (94%). Stimulated salivary flow was significantly lower in the hypertension group, similar to total protein content and salivary amylase activity. In summary, childhood hypertension is associated with hyposalivation as well as disturbances in antioxidant defense and enhanced oxidative/nitrosative damage both in the plasma/erythrocytes as well as saliva. Salivary UA may be a potential biomarker of hypertension in children.

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“…Risk factors such as hypertension, dyslipidemia, and adiposity may contribute to the development of CVD. Dyslipidemia is characterized by abnormal blood lipid levels, such as increased low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) and decreased high-density lipoprotein cholesterol (HDL-C) [ 2 ]. Dyslipidemia is a risk factor for the development of CVD and an important topic of research [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dyslipidemia is characterized by abnormal blood lipid levels, such as increased low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) and decreased high-density lipoprotein cholesterol (HDL-C) [ 2 ]. Dyslipidemia is a risk factor for the development of CVD and an important topic of research [ 2 ]. Recently, chromosomal regions and specific genes such as cholesterol ester transfer protein (CETP) and scavenger receptor class B type 1 (SCARB1) have been proposed to be associated with blood lipid levels [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the association between SCARB1 polymorphism and fasting blood lipid levels

Zheng

et al. 2017

Oncotarget

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Studies have shown that the scavenger receptor class B type 1 (SCARB1) rs5888 polymorphism impacts fasting blood lipid levels differently in men and women. A meta-analysis and statistical tests was therefore performed to determine the relationship between the rs5888 polymorphism and lipid levels in men and women. Twelve studies with 12,147 subjects were selected for this study. In a dominant model, the CT+TT genotype group had lower triglyceride levels than the CC group in men (standardized mean difference (SMD): −0.11; 95% confidence interval (CI): −0.21 to −0.02; P = 0.016; I2 = 51.5%). No statistical differences were detected in women. Subgroup analysis of different racial groups revealed significant correlation between the SCARB1 rs5888 polymorphism and higher high-density lipoprotein cholesterol (HDL-C) levels (SMD: 0.15; 95% CI: 0.08 to 0.21; P ≤ 0.001; I2 = 0%) and lower triglyceride levels (SMD: −0.16; 95% CI: −0.26 to −0.04; P = 0.013; I2 = 60.6%) in non-Asian men. No evidence of heterogeneity was observed when eliminating outlier studies, and no publication bias was detected. This meta-analysis suggests the SCARB1 rs5888 polymorphism is associated with higher HDL-C and lower triglyceride levels in non-Asian men.

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Lipid Screening in Childhood and Adolescence for Detection of Multifactorial Dyslipidemia

Cited by 84 publications

References 39 publications

Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study

Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study

A Case-Control Study of Salivary Redox Homeostasis in Hypertensive Children. Can Salivary Uric Acid be a Marker of Hypertension?

Meta-analysis of the association between SCARB1 polymorphism and fasting blood lipid levels

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