Lipid-stimulated somatostatin secretion in rainbow trout,Oncorhynchus mykiss

Carneiro, N M; Eilertson, Carmen D.; Sheridan, Mark A.

doi:10.1007/bf01875588

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…The fact that FA are able to stimulate somatostatin secretion in vivo and in vitro in rainbow trout (Carneiro et al 1996) suggests that FA are transported and further metabolized in the fish pancreatic tissue. In the present study, we show the nutritional regulation at molecular levels of key enzymes involved in both lipid synthesis and oxidation.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, pyruvate kinase (PK) and lactate dehydrogenase activities, and glyceraldehyde 3-phosphate, glycogen and glucose 6-phosphate levels were also reported to change with glucose levels in rainbow trout BB (Polakof et al 2007a, b;Polakof and Soengas 2008). On the other hand, as far as we are aware, lipid metabolism in fish pancreatic tissues remains unexplored and only lipid-stimulated somatostatin secretion (Carneiro et al 1996) and increased fatty acid synthase (FAS) gene expression in rainbow trout fed with carbohydrates have been reported (Polakof et al 2008b) to date.…”

Section: Introductionmentioning

confidence: 92%

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Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molecular level by nutritional status and carbohydrate intake

Polakof¹,

Skiba‐Cassy²,

Kaushik³

et al. 2011

J Comp Physiol B

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Glucose and lipid metabolism in pancreatic islet organs is poorly characterized. In the present study, using as a model the carnivorous rainbow trout, a glucose-intolerant fish, we assessed mRNA expression levels of several genes involved in glucose and lipid metabolism (including ATP-citrate lyase; carnitine palmitoyltransferase-1 isoforms, CPT; the mitochondrial isoform of the phosphoenolpyrutave carboxykinase, mPEPCK and pyruvate kinase, PK) and glucosensing (glucose transporter type 2, Glut2; glucokinase, GK and the potassium channel, K(ATP)) in Brockmann bodies. We evaluated the response of these parameters to changes in feeding status (food deprived vs. fed fish) as well as to changes in the amount of carbohydrate (dextrin) in the diet. A general inhibition of the glycolytic (including the glucosensing marker GK) and β-oxidation pathways was found when comparing fed versus food-deprived fish. When comparing fish feeding on either low- or high-carbohydrate diets, we found that some genes related to lipid metabolism were more controlled by the feeding status than by the carbohydrate content (fatty acid synthase, CPTs). Findings are discussed in the context of pancreatic regulation of glucose and lipid metabolism in fish, and show that while trout pancreatic metabolism can partially adapt to a high-carbohydrate diet, some of the molecular actors studied seem to be poorly regulated (K(ATP)) and may contribute to the glucose intolerance observed in this species when fed high-carbohydrate diets.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 92%

Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molecular level by nutritional status and carbohydrate intake

Polakof¹,

Skiba‐Cassy²,

Kaushik³

et al. 2011

J Comp Physiol B

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“…Indeed, lipids increase plasma SRIH levels in rainbow trout in vivo and stimulate the secretion of SRIH from isolated perfused rainbow trout Brockmann bodies (endocrine pancreas) [65]; glucose stimulates the secretion of SRIH from isolated perfused Brockmann bodies [66] as well as the expression of mRNAs encoding PPSS [67, 68]. …”

Section: Regulators Of Gh Involved In Energy Balancementioning

confidence: 99%

Comparative Aspects of GH and Metabolic Regulation in Lower Vertebrates

Rousseau

Dufour

2007

Neuroendocrinology

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In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations and long periods of fasting. In order to achieve the complex developmental programs associated with these changes, coordinated regulation of all aspects of energy metabolism is required. Somatotropic axis (somatostatin (SRIH) growth hormone (GH) and insulin-like growth factor 1 (IGF1), is known to be involved in the regulation of growth and energy balance. Interestingly, recent studies showed that additional factors such as pituitary adenylate cyclase-activated polypeptide (PACAP), corticotropin-releasing hormone (CRH), ghrelin and leptin could also have major roles in the control of growth and metabolism in lower vertebrates (fish, amphibians and reptiles). This mini-review will survey the function of GH and metabolic regulation in lower vertebrates.

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The role of somatostatins in the regulation of metabolism in fish

Sheridan

Kittilson

2004

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Lipid-stimulated somatostatin secretion in rainbow trout,Oncorhynchus mykiss

Cited by 5 publications

References 15 publications

Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molecular level by nutritional status and carbohydrate intake

Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molecular level by nutritional status and carbohydrate intake

Comparative Aspects of GH and Metabolic Regulation in Lower Vertebrates

The role of somatostatins in the regulation of metabolism in fish

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