Lipidized and aneurysmal fibrous histiocytoma with epithelial cysts on the left calf

Konishi, Eiichi; Nishimoto, Haruka; Ogari, Keiji; Kanehisa, Fuminao; Komori, Satoshi; Takenaka, Hideya; Katoh, Norito; Asai, Jun

doi:10.1111/1346-8138.13788

Cited by 3 publications

(1 citation statement)

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“…ABFHs have been described in the literature, but giant examples are rare. To our knowledge, only one has been reported to be bigger than 8.5 cm, but it was a mixed lipidized and aneurysmal type . Prior to this case, the biggest aneurysmal fibrous histiocytoma was described as 7.2 cm …”

Section: Discussionmentioning

confidence: 81%

Giant aneurysmal benign fibrous histiocytoma (dermatofibroma)

Liu

Lozeau

2018

J Cutan Pathol

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Aneurysmal benign fibrous histiocytomas are variants of dermatofibromas. These benign blood-filled lesions can mimic malignancies due to their rapid and recurrent growth. Our patient is a 42-year-old Caucasian female with a past medical history of morbid obesity, diabetes, and hypertension, who presented with a mass on her left shoulder for 5 years' duration. The mass oozed occasionally and would appear to regress but then recur replaced with progressively larger masses. Upon inspection, the patient had a large pedunculated exophytic mass with vascularity. The mass was surgically removed under general anesthesia via wide local excision. Grossly, the excised skin was purple-tinged with an underlying fungating solid mass measuring 8.5 cm. Serial sections revealed a hemorrhagic, spongy, and granular cut surface. Histologically, the epidermis was hyperplastic, with underlying hyaline collagen bundles. The remainder of the mass was chronically inflamed and composed of spindled histiocytes, hemosiderin-laden macrophages, and blood-filled spaces lacking an endothelial lining. There was focal pleomorphism but no significant atypia. Immunohistochemical stains were strongly positive for vimentin and negative for CD31, CD34, and desmin. The overall architecture and immunophenotype are consistent with the diagnosis of aneurysmal benign fibrous histiocytoma.

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Section: Discussionmentioning

confidence: 81%