Lipidized fibrous histiocytoma on the left condyle of the tibia

Lipidized and aneurysmal fibrous histiocytoma with epithelial cysts on the left calf

“…1f). 2 Podoplanin also has some utility for differentiating cutaneous tumors because some primary cutaneous tumors, such as squamous cell carcinoma, cylindroma and spiradenoma show diffuse positivity, but basal cell carcinoma is negative or only focally positive for…”

A pruritic pedunculated pink nodule on the leg

“…Histopathologically, lipidized fibrous histiocytoma is characterized by an infiltrate of predominantly foamy histiocytes that cover about 75% of the surface area, in association with abundant, distinctive hyalinized collagen bundles in the stroma that may appear keloid-like or osteoid-like [1][2][3][4]. Additionally, there are a few siderophages and a storiform pattern of fibroblast-like spindled cells [1].…”

Cholesterotic fibrous histiocytoma with no associated dyslipidemia

“…The main variants of dermatofibroma include cellular, aneurismal, epithelioid, and atypical fibrous histiocytomas. Many foam cells in the lesion might suggest lipidized fibrous histiocytoma, which is characterized histologically by accumulation of numerous foam cells, smaller numbers of siderophages, and stromal hyalinization, and concentrated strikingly in the lower limb, especially around the ankle . However, the presence of cholesterol deposits indicate cholesterotic fibrous histiocytoma.…”