Lipids: biomarkers of healthy aging

Almeida, Idália; Magalhães, Sandra; Nunes, Alexandra

doi:10.1007/s10522-021-09921-2

Cited by 26 publications

(19 citation statements)

References 202 publications

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“…Dyslipidemia can damage the cardiovascular system and induce cardiovascular diseases, such as coronary heart diseases, which threaten health [ 26 ]. Blood lipids as biomarkers of aging represent a significant avenue to probe healthy longevity [ 27 ]. TGs were one of the most important indicators of blood lipids.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Ren

et al. 2022

BioMed Research International

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Background. The pursuit of health and longevity is the eternal theme of humanity. Guangxi has a remarkable phenomenon of longevity in long-lived regions and ranks with the highest number of longevity villages in China, thus providing a natural advantage for health longevity research. Methods. In this study, we selected 117 natives of a longevity area in Guangxi, covering a large age range (38-118 years old) as subjects to measure peripheral leukocyte telomere length (LTL). Nineteen physical examination indicators and two inflammatory factor levels were measured. Results. Pearson’s analysis revealed a significant negative correlation between age and LTL ( r = − 0.3694 , p = 0.003 ), as well as alanine aminotransferase, albumin, total bilirubin, direct bilirubin, γ-glutamyltransferase, triglycerides, Interleukin-10, and tumor necrosis factor type-α. Systolic blood pressure and blood urea nitrogen were positively correlated with age. In addition, LTL decreased in people aged 38–89 years, and an upward trend was observed in people aged older than 90 years. Conclusions. Longevity individuals have characteristics, such as longer LTL, good hepatic function, and lower triglycerides and inflammation levels.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Ren

et al. 2022

BioMed Research International

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“…Age-related and tissue-specific changes in lipid composition can contribute to the aging process. The quantification of these alterations in the lipidome in healthy aging organisms revealed a general systematic trend in lipid profile changes ( Almeida et al, 2021 ; Chung, 2021 ). Of note, the lipidome composition itself and age-related changes can be impacted by different factors like diet ( Nam et al, 2017 ; Surma et al, 2021 ) and genetic background ( Wong et al, 2020 ; McGurk et al, 2021 ).…”

Section: Lipids Alterations During Agingmentioning

confidence: 99%

Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals

Gille¹,

Galuska²,

Fuchs³

et al. 2021

Front. Aging

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Lipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid pathways. Lipidome analysis revealed age-related changes in the lipid composition of various tissues in mice and humans, which were also influenced by diet and gender. Some changes in the lipid profile can be linked to the onset of age-related neurodegenerative diseases like Alzheimer’s disease. Furthermore, the excessive accumulation of lipid storage organelles, lipid droplets, has significant implications for the development of inflammaging and non-communicable age-related diseases. Dietary interventions such as caloric restriction, time-restrictive eating, and lipid supplementation have been shown to improve pertinent health metrics or even extend life span and thus modulate aging processes.

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“…In muscle, the authors detected 65 metabolites that changed with age, most of them related to fatty acid metabolism [22]. These results indicated that lipids suffer alterations throughout the aging process and may be used to predict age [23]. In another study, Zhou et al found an increase in 18:0 ceramides in aged skeletal muscle [24], and Wong et al [25] studied the lipidome of human plasma during aging and found a generalized decrease in the levels of all lipid classes in older individuals, independently of sex and body mass index.…”

Section: Discussionmentioning

confidence: 95%

FTIR Spectroscopy as a Tool to Study Age-Related Changes in Cardiac and Skeletal Muscle of Female C57BL/6J Mice

et al. 2021

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Studying aging is important to further understand the molecular mechanisms underlying this physiological process and, ideally, to identify a panel of aging biomarkers. Animals, in particular mice, are often used in aging studies, since they mimic important features of human aging, age quickly, and are easy to manipulate. The present work describes the use of Fourier Transform Infrared (FTIR) spectroscopy to identify an age-related spectroscopic profile of the cardiac and skeletal muscle tissues of C57BL/6J female mice. We acquired ATR-FTIR spectra of cardiac and skeletal muscle at four different ages: 6; 12; 17 and 24 months (10 samples at each age) and analyzed the data using multivariate statistical tools (PCA and PLS) and peak intensity analyses. The results suggest deep changes in protein secondary structure in 24-month-old mice compared to both tissues in 6-month-old mice. Oligomeric structures decreased with age in both tissues, while intermolecular β-sheet structures increased with aging in cardiac muscle but not in skeletal muscle. Despite FTIR spectroscopy being unable to identify the proteins responsible for these conformational changes, this study gives insights into the potential of FTIR to monitor the aging process and identify an age-specific spectroscopic signature.

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Lipids: biomarkers of healthy aging

Cited by 26 publications

References 202 publications

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals

FTIR Spectroscopy as a Tool to Study Age-Related Changes in Cardiac and Skeletal Muscle of Female C57BL/6J Mice

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