Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease

Glišić, Sanja; Arrigo, Paul; Alavantić, Dragan; Perovic, Vladimir; Prljić, Jelena; Veljković, Nevena

doi:10.1002/prot.21581

Cited by 15 publications

(14 citation statements)

References 41 publications

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“…The balance of two factors would decide and maintain the concentration of TG in blood. The drop in blood TG concentration after consecutive intake of MLCT oil might be possibly explained as (1) a reduction of hepatic secretion of TG in form of verylow-density lipoprotein into blood, (2) an increase in the clearance of TG from blood by lipoprotein lipase, an enzyme playing the major role in regulating the catabolism of TG-rich lipoproteins (Glisic et al, 2007), or (3) a combination of the above, or (4) an increase in the removal of TG without a change in hepatic secretion of TG, or (5) both increases in hepatic production and peripheral clearance of TG, but the magnitude of the former is less than that of the latter. However, there were few reports indicative of the decreasing effect of MCT or MLCT intake on hepatic production of TG so far.…”

Section: Discussionmentioning

confidence: 99%

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

et al. 2009

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Objectives: To investigate the effects of medium-and long-chain triacylglycerol (MLCT) on blood triglyceride (TG) in Chinese hypertriglyceridemic subjects. Methods: A double-blind controlled clinical trial was carried out, in which 112 subjects with hypertriglyceridemia were randomly divided into two dietary oil groups: (1) long-chain triacylglycerol (LCT) and (2) MLCT. All subjects were requested to ingest fixed energy and to continue their normal activity levels, and to consume LCT or MLCT oil at 25-30 g daily during the study period. Anthropometric measurements of body weight, body mass index (BMI), body fat, body fat percentage, waist and hip circumference (WC and HC), areas of subcutaneous and visceral fat by computed tomography scanning and blood biochemical markers were measured at the beginning and end of the study. Results: There were 50 and 51 subjects left in LCT and MLCT groups, respectively. There were no significant differences in daily intake of energy, protein, fat and carbohydrate, as well as the daily physical activity between the two groups during the study. After 8 weeks, MLCT group showed a significant decrease in body weight, BMI, WC, HC, ratio of WC and HC, body fat, body fat percentage and subcutaneous fat when compared with the initial values. The decrease in body weight, BMI, WC, body fat and subcutaneous and visceral fat was significantly greater in MLCT group than that in the LCT group. Furthermore, the serum concentrations of TG in MLCT group were significantly lower than those in the LCT group. Conclusions: Consumption of MLCT may reduce body weight, body fat and blood TG in hypertriglyceridemic subjects under an appropriate dietary regime.

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Section: Discussionmentioning

confidence: 99%

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

et al. 2009

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“…ISM has been used successfully several times as an initial step in the identification of partner protein interactors and interacting protein domains 20–25. In the present work, we used the ISM to predict HIV‐1 IN domains that were potentially involved in an interaction with LEDGF/p75.…”

Section: Introductionmentioning

confidence: 99%

Computational studies of the interaction between the HIV‐1 integrase tetramer and the cofactor LEDGF/p75: Insights from molecular dynamics simulations and the Informational spectrum method

Tintori¹,

Veljković²,

Veljković³

et al. 2010

Proteins

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A crystal structure of the integrase binding domain (IBD) of the lens epithelium-derived growth factor (LEDGF/p75) in complex with the dimer of the HIV-1 integrase (IN) catalytic core domain (CCD) provides useful information that might help in the understanding of essential protein-protein contacts in HIV-1. However, mutagenic studies indicated that interactions between the full-length proteins were more extensive than the contacts observed in the co-crystal structure of the isolated domains. On the other hand, the biochemical characterization of the interaction between full-length IN and LEDGF/p75 has recently proved that LEDGF/p75 promotes IN tetramerization with two LEDGF/p75 IBD molecules bound to the IN tetramer. This experimental evidence suggests that to obtain a complete structural description of the interactions between the two proteins, the full-length tetrameric structure of IN should be considered. Our aim was to obtain a detailed picture of HIV-1 IN interactions with cellular co-factors that was of general interest, particularly for the development of small molecule IN inhibitors, which mimic the IBD of LEDGF/p75. To this end, we performed bioinformatics analyses to identify protein sequence domains involved in long-range recognition. Subsequently, we applied molecular dynamics techniques to investigate the detailed interactions between the complete tetrameric form of IN and two molecules of the IBD of LEDGF/p75. Our dynamic picture is in agreement with experimental data and, thereby, provides new details of the IN-LEDGF/p75 interaction.

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“…These studies usually focus on deleterious loss-of-function mutations that follow the Mendelian pattern of inheritance [21,22]. The disadvantage of candidate gene analysis is the lessened possibility for detection of new genetic variants or novel genes.…”

Section: Genetic Markers For Cadmentioning

confidence: 99%

Genetic Markers for Coronary Artery Disease

et al. 2018

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Coronary artery disease (CAD) and myocardial infarction (MI) are recognized as leading causes of mortality in developed countries. Although typically associated with behavioral risk factors, such as smoking, sedentary lifestyle, and poor dietary habits, such vascular phenotypes have also long been recognized as being related to genetic background. We review the currently available data concerning genetic markers for CAD in English and non-English articles with English abstracts published between 2003 and 2018. As genetic testing is increasingly available, it may be possible to identify adequate genetic markers representing the risk profile and to use them in a clinical setting.

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Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease

Cited by 15 publications

References 41 publications

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

Computational studies of the interaction between the HIV‐1 integrase tetramer and the cofactor LEDGF/p75: Insights from molecular dynamics simulations and the Informational spectrum method

Genetic Markers for Coronary Artery Disease

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