Liposome mediated pulmonary drug delivery system: An updated review

Paul, Susanta; Roy, Tathagata; Bose, Anannya; Chatterjee, D P; Chowdhury, Victor Roy; Rana, Meghamouli; Das, Ashmita

doi:10.5958/0974-360x.2021.00318.8

Cited by 5 publications

(2 citation statements)

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“…However, inhaled free drugs are highly toxic, tend to be rapidly cleared, and have a nonspecific distribution in the lungs. The use of pulmonary inhalation nanodrug delivery systems for the treatment of lung diseases has many advantages; nanocarriers can encapsulate toxic drugs and release them in a more specific and controlled manner [14,15]. It has been shown that particles obtained by liposome nebulization remain homogeneous and stable and significantly reduce tumor volume in mice [16].…”

Section: Introductionmentioning

confidence: 99%

Polyethylene Glycol-Modified Cationic Liposome as a Promising Nano Spray for Acute Pneumonia Treatment

Wang,

Chen,

Zhang

et al. 2024

Polymers

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Acute pneumonia (AP), triggered primarily by pathogens like bacteria and viruses, is a leading cause of human mortality. Ribavirin, a broad-spectrum antiviral agent, plays a pivotal role in the treatment of AP. However, its therapeutic use is hindered by the need for high dosages and the associated cardiac and hepatic toxicities. In this study, we synthesized polyethylene glycol-modified cationic liposomes to encapsulate ribavirin (RBV-PCL) and formulated it into a spray, aiming to enhance the effectiveness of RBV through respiratory administration. Lipopolysaccharide (LPS), a compound known to induce AP models in animals, was utilized in our research. Successfully, we established an acute pneumonia model in mice using aerosol inhalation. Through animal experiments, we investigated the therapeutic effects of RBV-PCL on mice with AP. In vivo studies revealed promising results. RBV-PCL effectively prolonged the survival of mice with AP, significantly reduced the levels of inflammatory markers such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and inhibited the infiltration of neutrophils in the lungs and spleens of mice. These findings suggest that RBV-PCL can effectively suppress the inflammatory response in mice with AP, thus holding significant potential as a novel therapeutic approach for the treatment of acute pneumonia.

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Section: Introductionmentioning

confidence: 99%

Polyethylene Glycol-Modified Cationic Liposome as a Promising Nano Spray for Acute Pneumonia Treatment

Wang,

Chen,

Zhang

et al. 2024

Polymers

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“…Liposomes are microscopic, spherical particles made up of phospholipids with a double-layered membrane and are a colloidal transport system (Paul et al, 2021), which can enclose both hydrophilic and lipophilic drugs within bilayers and deliver their contents where free forms cannot reach, has been an interesting subject in the past decades as drug carriers with great potential (Cuomo et al, 2017;Van der Koog et al, 2022). However, the poor stability of conventional liposomes (sensitive to low pH, oxidation, and decomposition by enzymes) has the potential to lose the loaded bioactive substances, thus limiting their appli-cation (Cauzzo et al, 2020;He et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Co‐encapsulation of rutinoside and β‐carotene in liposomes modified by rhamnolipid: Antioxidant activity, antibacterial activity, storage stability, and in vitro gastrointestinal digestion

Wang

et al. 2023

Journal of Food Science

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The surfactant rhamnolipid (RL) was used to modify the liposomes. β‐carotene (βC) and rutinoside (Rts) were utilized to generate co‐encapsulated liposomes through an ethanol injection method that used both hydrophilic and hydrophobic cavities to fabricate a novel cholesterol‐free composite delivery system. The RL complex‐liposomes loaded with βC and Rts (RL–βC–Rts) showed higher loading efficiency and good physicochemical properties (size = 167.48 nm, zeta‐potential = −5.71 mV, and polydispersity index = 0.23). Compared with other samples, the RL–βC–Rts showed better antioxidant activities and antibacterial ability. Moreover, dependable stability was uncovered in RL–βC–Rts with still 85.2% of βC storage from nanoliposome after 30 days at 4°C. Furthermore, in simulated gastrointestinal digestion, βC exhibited good release kinetic properties. The present study demonstrated that liposomes constructed from RLs offer a promising avenue for the design of multicomponent nutrient delivery systems using both hydrophilic.

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The most common route of administration used during COVID-19

Khalil¹,

Hameed²,

Hanna³

2023

AJPS

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the virus that caused the COVID-19 pandemic. Initial symptoms include fever, cough, and dyspnea. Symptoms include nausea, vomiting, and abdominal pain, GIT involvement is also possible. The COVID-19 outbreak has increased the need for alternative medicine administration routes, particularly in public places. Buccal, sublingual, and rectal administration are all considered transmucosal methods. They are self-administration options for non-invasive systemic distribution. In addition, they are great for use in palliative and end-of-life care because of their quick onset of action and decreased first-pass metabolism. A mucosal atomization device allows for the intranasal administration of a parenteral formulation through nasal spray. Rectal mucosal absorption is comparable to that of the oral route, making the rectal route an extremely versatile and useful method of drug administration for a wide variety of medications. Covid-19 illness is treated with a variety of drugs, including anti-malaria medication (hydroxychloroquine), glucocorticoids (dexamethasone), antibiotics (azithromycin), and antiviral medications (favipiravir). This article discusses the route of drug administration for COVID-19, as well as symptoms, treatments, and the various ways it can be spread

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Liposome mediated pulmonary drug delivery system: An updated review

Cited by 5 publications

References 0 publications

Polyethylene Glycol-Modified Cationic Liposome as a Promising Nano Spray for Acute Pneumonia Treatment

Polyethylene Glycol-Modified Cationic Liposome as a Promising Nano Spray for Acute Pneumonia Treatment

Co‐encapsulation of rutinoside and β‐carotene in liposomes modified by rhamnolipid: Antioxidant activity, antibacterial activity, storage stability, and in vitro gastrointestinal digestion

The most common route of administration used during COVID-19

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