Lipoxidation adducts with peptides and proteins: Deleterious modifications or signaling mechanisms?

Domingues, Rosário; Domingues, Pedro; Melo, Tânia; Pérez‐Sala, Dolores; Reis, Ana; Spickett, Corinne M.

doi:10.1016/j.jprot.2013.06.004

Cited by 146 publications

(158 citation statements)

References 212 publications

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“…Free radical damages can accumulate over time and may thereby contribute to cell injury and development of human diseases including atherosclerosis, diabetes, cancer, chronic inflammatory diseases and neurodegenerative diseases as well as in the process of aging [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Adedapo

Olusanya

Takure

2015

Int Jour of Biomed Res

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A number of studies have investigated the roles of lipid peroxidation/ anti-oxidative balance as risk factors of prostate cancer. However, no study has yet to relate these factors with dietary habits of individuals in this environment. The objective of this study was to assess the role of lipid peroxidation and its relationship with vitamin D, calcium and dietary habits in individuals with prostate cancer. A total of sixty four (64) male participants (32 patients and 32 age-matched apparently healthy individuals as control) were recruited. Blood samples were analyzed for Malondialdehyde (MDA), Total antioxidant status (TAS), Calcium and Albumin spectrophotometrically; Prostate specific antigen (PSA) using immune radiometric assay; and Vitamin D by high performance liquid chromatography. Participants with prostate cancer had a significantly higher (p≤ 0.05) mean plasma level of MDA and PSA but lower TAS and vitamin D when compared with the control group. The plasma levels of MDA had a significant positive correlation with plasma PSA while negative with TAS in both groups. A significant proportion of the study participants that consumed dairy and smoked food regularly had a higher mean plasma level of MDA when compared with those that did not regularly as well as the control. This study has provided support for the hypothesis that lipid peroxidation and oxidative stress is associated with prostate cancer. A peculiar relationship exists between dairy and smoked food in prostate cancer which may be linked with increased lipid peroxidation.

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Section: Introductionmentioning

confidence: 99%

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Adedapo

Olusanya

Takure

2015

Int Jour of Biomed Res

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“…We have recently reviewed the methodology and challenges of proteomic analysis of modifications by various inflammatory mediators, which in many cases may be applicable to drug-protein interactions [42,44]. Nonetheless, combinations of approaches will be needed to fully characterize the protein modifications generated in pathophysiological conditions under therapeutic regimes.…”

Section: Interactions With Inflammationmentioning

confidence: 99%

Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies

González-Morena¹,

Montanez²,

Aldini³

et al. 2017

CPD

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Drug hypersensitivity reactions result from the activation of the immune system by drugs or their metabolites. The clinical presentations of drug hypersensitivity can range from relatively mild local manifestations to severe systemic syndromes that can be life-threatening. As in other allergic reactions, the causes are multifactorial as genetic, metabolic and concomitant factors may influence the occurrence of drug hypersensitivity. Formation of drug protein adducts is considered a key step in drug adverse reactions, and in particular in the immunological recognition in drug hypersensitivity reactions. Nevertheless, non-covalent interactions of drugs with receptors in immune cells or with MHC clefts and/or exposed peptides can also play an important role. In recent years, development of proteomic approaches has allowed the identification and characterization of the protein targets for modification by drugs in vivo and in vitro, the nature of peptides exposed on MHC molecules, the changes in protein levels induced by drug treatment, and the concomitant modifications induced by danger signals, thus providing insight into context factors. Nevertheless, given the complexity and multifactorial nature of drug hypersensitivity reactions, understanding the underlying mechanisms also requires the integration of knowledge from genomic, metabolomic and clinical studies.

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“…As ECRs formadas durante as reações de peroxidação lipídica podem ser divididos em três principais classes: (1) aldeídos α,β-insaturados, exemplificados pelo 4-hidroxi-2--nonenal (HNE), 4-hidroxi-hexenal (HHE), nonenal e acroleína; (2) di-aldeídos, como o malondialdeído e o GO; e (3) cetoaldeídos, como o metilglioxal (MG), o 4 oxo-nonenal e os isocetais, também chamados isolevuglandinas (isoLGs) (Figura 4). 5,17 Além desses, as ECRs precursoras de ALEs também incluem fosfolipídeos oxidados contendo regiões eletrofílicas capazes de reagir covalentemente com regiões nucleofílicas de proteínas, formando as características bases de Schiff. 18 A catepsina B e a angiotensina II são exemplos de alvos endógenos dos fosfolipídeos oxidados.…”

Section: A Reação De Maillard E Os Mecanismos De Formação Dos Produtounclassified

DETERMINATION OF ADVANCED GLYCATION (AGEs) AND LIPOXIDATION (ALEs) END PRODUCTS IN FOODS AND BIOLOGICAL SYSTEMS: ADVANCES, CHALLENGES AND PERSPECTIVES

Barbosa¹,

Souza²,

Santana³

et al. 2016

Química Nova

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Lipoxidation adducts with peptides and proteins: Deleterious modifications or signaling mechanisms?

Cited by 146 publications

References 212 publications

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan

Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies

DETERMINATION OF ADVANCED GLYCATION (AGEs) AND LIPOXIDATION (ALEs) END PRODUCTS IN FOODS AND BIOLOGICAL SYSTEMS: ADVANCES, CHALLENGES AND PERSPECTIVES

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