Liquid acrylate‐endcapped biodegradable poly(ϵ‐caprolactone‐co‐trimethylene carbonate). II. Computer‐aided stereolithographic microarchitectural surface photoconstructs

Abstract

Advanced micromedical devices may require computer-aided photofabrication, by which microarchitectural surface design and entire macroshaped body design are feasible. Liquid acrylate-endcapped poly(epsilon-caprolactone-co-trimethylene carbonate)s, poly(CL/TMC)s, prepared using trimethylene glycol (TMG) or poly(ethylene glycol) (PEG) as an initiator and an acrylate group for subsequent terminal capping, were used as photocurable copolymers. The stereolithographically microarchitectured photoconstructs were prepared using a custom-designed apparatus with a moving ultraviolet (UV) light pen driven by a computer-assisted design program. The prepared photoconstructs included microneedles, a microcylinder and microbanks on surfaces. In vitro hydrolytic degradation proceeded with surface erosion when hydrophobic TMG-based photocured copolymers were employed, whereas very fast degradation of hydrophilic PEG-based photocured copolymers probably via concerted actions of surface erosion and bulk degradation was observed. In vivo hydrolytic behavior upon subcutaneous implantation in rats indicated that surface erosion proceeded for TMG-based photoconstructs. Anti-inflammatory drug (indomethacin) loading into microneedle-structured surfaces minimized inflammatory reactions. The possible biomedical microarchitectural three dimensinal in biomedical application photoconstructs was discussed.

Bioprinting and Tissue Engineering: Recent Advances and Future Perspectives

“…Chloroform was used for selective solvation of the polymeric particles, resulting in particle adhesion upon chloroform evaporation. Matsuda [46] developed ultraviolet (UV) radiationÀpolymerizable and biodegradable materials for SLA, [38] and Hutmacher [47] used the FDM technique [40] and optimized its building process parameters in order to permit the use of polycaprolactone for building scaffolds with a honeycomb internal architecture. Below is a short description of some of the major AM techniques used today for fabrication of 3D polymeric objects.…”

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

“…Results showed that higher coumarin functionality and UV light intensity, and a reduced layer thickness of the liquid film precursor increases the photocuring reaction. The same oligomers were used by Matsuda and Mizutani [66] to produce photocurable copolymers, using trimethylene glycol or PEG as initiator and an acrylate group (acryloyl chloride) to end-functionalize the oligomers. Different structures were produced using the photocurable copolymers through stereolithography, as shown in Fig.…”

Advanced microstructures based on poly(trimethylene carbonate) : microfabrication and stereolithography

“…Resins based on poly(propylene fumarate), poly(ethylene glycol), poly(D,L-lactide) and (co)polymers of trimethylene carbonate and -caprolactone have been investigated for these purposes. [62,[65][66][67][68][69][70][71][72] The use of these resins results in the formation of brittle or rigid networks.…”