Liquid chromatography/atmospheric pressure photoionization tandem mass spectrometry for analysis of Dechloranes

Zhou, Simon Ningsun; Reiner, Eric J.; Märvin, Chris H.; Helm, Paul A.; Shen, Li; Brindle, Ian D.

doi:10.1002/rcm.4874

Cited by 15 publications

(13 citation statements)

References 8 publications

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“…Separation of the LC-MS/MS method was faster, but GC-HRMS provided better sensitivity (Zhou et al, 2011a).…”

Section: Methods Of Analysismentioning

confidence: 99%

“…phase provided the best separation (using a methanol-water gradient), in less than 5 minutes. Separation of the LC-MS/MS method was faster, but GC-HRMS provided better sensitivity (Zhou et al, 2011a).…”

Section: Methods Of Analysismentioning

confidence: 99%

“…Ions monitored were m/z 417.70 and 419.70(Guerra et al, 2012;Shen et al, 2011) Yang et al (2011). used GC-ECNI-MS, monitoring the m/z 79 and 81 ions Zhou et al (2011a). evaluated LC-MS for the analysis of dechlorane compounds.…”

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confidence: 99%

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Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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EFSA was asked to deliver a scientific opinion on brominated flame retardants (BFRs) other than PBDEs, PBBs, HBCDDs, TBBPA and brominated phenols and their derivatives. The BFRs that are the subject of the current opinion, were classified in groups termed "emerging" and "novel" BFRs. Information on 17 emerging and 10 novel BFRs was collected. The information varied widely for these BFRs. There is a lack of experimental data on physico-chemical characteristics, stability/reactivity and current use and production volume of all the emerging and novel BFRs. Due to the very limited information on occurrence, exposure and toxicity, the CONTAM Panel could not perform a risk characterisation for any of the BFRs considered. Instead, an attempt was made to identify those BFRs that could be a potential health concern and should be considered first for future investigations. For this purpose the Panel first evaluated the available experimental data on occurrence in food, behaviour in the environment and toxicity. Secondly, a modelling exercise was performed focussing on the potential of the emerging and novel BFRs for persistence in the environment and for their possible bioaccumulation potential. There is convincing evidence that tris(2,3-dibromopropyl) phosphate (TDBPP) and dibromoneopentyl glycol (DBNPG) are genotoxic and carcinogenic, warranting further surveillance of their occurrence in the environment and in food. Based on the limited experimental data on environmental behaviour, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and hexabromobenzene (HBB) were identified as compounds that could raise a concern for bioaccumulation. For the modelling exercise, the CONTAM Panel selected two environmental characteristics, overall persistence and potential for bioaccumulation, as being most relevant to provide insight into the possibility that emerging or novel BFRs The less well known and less studied BFRs, subject of the current opinion, were grouped into two classes, referred to herein as "emerging" and "novel" BFRs. Emerging BFRs are defined as chemicals which are applied as flame retardants and that have been identified in any environmental compartment, in wildlife, in food or in humans. It should be noted that the definition for the emerging BFRs, used in this opinion, does not imply that there is evidence for an increasing trend in the concentration of these BFRs in the environment, in food or in human samples. Novel BFRs are defined as chemicals applied as flame retardants, with confirmed presence in materials and/or goods in concentrations above 0.1 %, but not identified in environmental samples, wildlife, food or humans. In total, information on 27 BFRs, of which 17 were identified as "emerging" and 10 as "novel", was collected by the CONTAM Panel, and it was noted that the available information varied widely for the various individual BFRs.In general, there is a lack of experimental data on physico-chemical characteristics and stability/reactivity for all the emerging and novel BFRs. This sometimes hampered ...

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“…Separation of the LC-MS/MS method was faster, but GC-HRMS provided better sensitivity (Zhou et al, 2011a).…”

Section: Methods Of Analysismentioning

confidence: 99%

Section: Methods Of Analysismentioning

confidence: 99%

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Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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“…21 The K OW values of Cl 11 DP was expected to be lower than DP due to the less chlorine atom, and field investigation has reported their 10-folds higher bioaccumulation potentials in freshwater fish compared to parent DP. 20 As for Dec 602 and Dec 603, their logK OW values were 8.1 and 11.2, respectively, 19 and experimental exposure data on Atlantic salmon indicated relatively high bioaccumulation potential of Dec 602 compared with Dec 603 and DP. 22 Similar high bioaccumulation potential of Dec 602 than Dec 603 and DP were also found in lake trout from Great Lakes, 14,17 and marine invertebrates in coastal environment of Northern China.…”

Section: ■ Introductionmentioning

confidence: 91%

Trophic Transfer of Dechloranes in the Marine Food Web of Liaodong Bay, North China

Peng

Wan

Zhang

et al. 2014

Environ. Sci. Technol.

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Dechloranes are of particular concern because of their ubiquity in environmental matrices, but little is known about their trophic transfer in aquatic food web. This study investigated the trophic transfer of seven dechloranes in a marine food web from Liaodong Bay, China. Dechloranes were determined in sediments and 15 marine species including benthic invertebrates, fish and gulls collected from Liaodong Bay. Biomagnification factors (BMFTL) of dechloranes in black-headed gulls were calculated to be 6.4, 1.7, 0.45, 0.36, 0.14, and 0.11 for mirex, Dechlorane 602 (Dec 602), Dechlorane 603 (Dec 603), antiundecachloropentacyclooctadecadiene (anti-Cl11DP), syn-dechlorane plus (syn-DP), and anti-DP. Significantly positive relationships were found between lipid equivalent concentrations of mirex, Dec 602, and anti-Cl11DP and trophic levels, and the trophic magnification factors (TMFs) were 13, 3.7, and 5.6, respectively, indicating that these compounds undergo trophic magnification in the aquatic food web. Lipid equivalent concentrations of Dec 603 and DP isomers did not exhibit a statistically significant correlation with trophic levels. The relatively low trophic magnification potentials of Dec 603 and DP isomers were possibly due to their extreme hydrophobicity (logKOW: 11.2-11.3) and subsequent low bioavailabilities compared with mirex (7.0), Dec 602 (8.1) and anti-Cl11DP. The results provided important information for understanding the ecological risk of dechloranes.

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“…A variety of ions, such as negative molecular ions, deprotonated molecules, fragments (typically loss of halogen), oxidation products (e.g., [M À X þ O] À ), and adducts ([M þ X] À ) can be formed to make identification of unknown compounds challenging. The ions can be similar to those formed in negative-ion APCI, as shown for dichloranes (Zhou et al, 2011). Adduct formation can sometimes be used for sensitivity enhancement, as shown by inclusion of brominated reagents (Osborne et al 2013) into the dopant flow for analysis of brominated compounds (Ross & Wong, 2010).…”

Section: Environmentalmentioning

confidence: 99%

Recent developments in atmospheric pressure photoionization‐mass spectrometry

Kauppila

Syage

Benter

2015

Mass Spectrometry Reviews

110

108

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Recent developments in atmospheric pressure photoionization (APPI), which is one of the three most important ionization techniques in liquid chromatography-mass spectrometry, are reviewed. The emphasis is on the practical aspects of APPI analysis, its combination with different separation techniques, novel instrumental developments - especially in gas chromatography and ambient mass spectrometry - and the applications that have appeared in 2009-2014. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:423-449, 2017.

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Liquid chromatography/atmospheric pressure photoionization tandem mass spectrometry for analysis of Dechloranes

Cited by 15 publications

References 8 publications

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

Trophic Transfer of Dechloranes in the Marine Food Web of Liaodong Bay, North China

Recent developments in atmospheric pressure photoionization‐mass spectrometry

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