Liquid Ventilation Improves Pulmonary Function, Gas Exchange, and Lung Injury in a Model of Respiratory Failure

Hirschl, Ronald B.; Parent, Alan; Tooley, Richard; McCracken, Michael S.; Johnson, Kent J.; Shaffer, Thomas H.; Wolfson, Marla R.; Bartlett, Robert H.

doi:10.1097/00000658-199501000-00010

Cited by 146 publications

(52 citation statements)

References 18 publications

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“…70,81,83,107,108 The foundation for this approach is related to removal of the caustic substance (i.e., meconium) or alveolar fluid accumulation. In a group of meconium-stained preterm lambs, poor oxygen exchange, acidosis, and low pulmonary compliance was present at birth and during CMV.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Liquid-assisted ventilation: An alternative respiratory modality

1998

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Section: Preclinical Studiesmentioning

confidence: 99%

Liquid-assisted ventilation: An alternative respiratory modality

1998

Self Cite

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“…93,94 In another study, severe respiratory failure was induced with oleic acid in young sheep. 95 Improved pulmonary mechanics (increased compliance), improved oxygenation, and marked reduction in alveolar haemorrhage, lung fluid accumulation and inflammatory infiltration was demonstrated in the PFOB group, as compared to the gas ventilated animals. A human adult trial found significant improvement in physiological shunt and static pulmonary compliance.…”

Section: Partial Liquid Ventilation With Fluorocarbons: Improvement Omentioning

confidence: 89%

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

Krafft

2015

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In many pulmonary conditions serum proteins interfere with the normal adsorption of components of the lung surfactant to the surface of the alveoli, resulting in lung surfactant inactivation, with potentially serious untoward consequences. Here, we review the strategies that have recently been designed in order to counteract the biophysical mechanisms of inactivation of the surfactant. One approach includes protein analogues or peptides that mimic the native proteins responsible for innate resistance to inactivation. Another perspective uses water-soluble additives, such as electrolytes and hydrophilic polymers that are prone to enhance adsorption of phospholipids. An alternative, more recent approach consists of using fluorocarbons, that is, highly hydrophobic inert compounds that were investigated for partial liquid ventilation, that modify interfacial properties and can act as carriers of exogenous lung surfactant. The latter approach that allows fluidisation of phospholipid monolayers while maintaining capacity to reach near-zero surface tension definitely warrants further investigation.

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“…A VLP, quando comparada com ventilação convencional, apresenta impacto positivo na sobrevida e melhora da arquitetura pulmonar, com redução das alterações histológicas e morfológicas em modelos de lesão pulmonar aguda (54,55) . (56) , hemorragia e inflamação (57) .…”

Section: J Pneumol 28(6) -Nov-dez De 2002unclassified

“…Recentemente, a ventilação líquida parcial com perfluorocarbono tem sido uma alternativa para a ventilação mecânica convencional no manejo da SDRA (54,55) . Os perfluorocarbonos funcionam como uma PEEP líqui-da, por manterem os alvéolos abertos durante a lesão pulmonar.…”

Section: J Pneumol 28(6) -Nov-dez De 2002unclassified

Ventilação líquida: revisão da literatura

2002

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Atualmente, novas alternativas de ventilação têm sido estudadas em quadros de insuficiência respiratória, com o objetivo de melhorar a oxigenação e minimizar a agressão ao parênquima pulmonar. A utilização de perfluorocarbonos líquidos administrados diretamente na via aérea vem sendo ostensivamente estudada em modelos de lesão pulmonar e em alguns ensaios clínicos, demonstrando bons resultados com relação à troca gasosa, mecânica ventilatória e propriedades antiinflamatórias. Os PFCs são substâncias que possuem baixa tensão superficial, alta densidade, são insolúveis em água, além de permitirem alta difusão de oxigênio e gás carbônico. Esses compostos atuam recrutando alvéolos colapsados, melhorando a oxigenação, protegendo a arquitetura pulmonar e atuando como carreadores de impurezas, limpando a superfície alveolar de resíduos da degradação celular. Neste artigo de revisão são apresentadas as diferentes modalidades ventilatórias com perfluorocarbonos e fornecidas informações sobre a utilização e o estado atual da ventilação líquida. (J Pneumol 2002;28(6):351-61)

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Liquid Ventilation Improves Pulmonary Function, Gas Exchange, and Lung Injury in a Model of Respiratory Failure

Abstract: In a model of severe respiratory failure, LV improves pulmonary gas exchange and compliance with an associated reduction in alveolar hemorrhage, edema, and inflammatory infiltrate.

Cited by 146 publications

References 18 publications

Liquid-assisted ventilation: An alternative respiratory modality

Liquid-assisted ventilation: An alternative respiratory modality

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

Ventilação líquida: revisão da literatura

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