List of Drugs in Development for Neurodegenerative Diseases

Procognitive 5-HT6 antagonists in the rat forced swimming test: Potential therapeutic utility in mood disorders associated with Alzheimer's disease

“…Preclinical evidence has suggested a possible role for the 5-HT 6 receptor in the treatment of cognitive dysfunction (Woolley et al 2001;Schreiber et al 2007) since 5-HT 6 antagonists enhance brain acetylcholine levels in the extracellular space (Riemer et al 2003). This concept is based on the clinical success of AChE inhibitors such as donepezil, and indeed 5-HT 6 antagonists are currently being developed for Alzheimer's disease in clinical trials (Kwon et al 2004;Hunter 2007).…”

Inhibitors and Modulators of β- and γ-Secretase

“…More than 50 compounds are in development to treat AD [4][5]. They target a whole range of known receptors and *Address correspondence to this author at the Clemens Schöpf-Institute for Organic Chemistry and Biochemistry, TU Darmstadt, Petersenstrasse 22, D-64287 Darmstadt, Germany; E-mail: Schmidt_Boris@t-online.de enzymes: GSK-3, PDE 4, and muscarinic M1 amongst others.…”

Drug Development and PET-Diagnostics for Alzheimers Disease

“…At least 10% of these are related to AD [15,16]. The targets derive from a whole range of sometimes well-known receptors and enzymes: GSK-3, PDE 4 and muscarinic M1.…”

“…The Elan compounds (13)(14)(15)(16)(17)(18)(19) have lost a good part of their peptidic origin, which is mandatory to obtain sufficient oral absorption and blood brain barrier penetration [89,90]. Significant information was revealed by a novel BACE complexed to a transition state mimetic [91].…”

“…BACE inhibitors II.the compounds 14-21. The switch from the statine core to the hydroxyethylene isoster allowed the replacement of the carboxylic acids by smaller groups, and resulted in the compact inhibitors(16)(17)(18)(19) with reduced molecular mass and fewer hydrogen bond donors.…”