Listeria meningitis: Report of ten recent cases and review of current therapeutic recommendations

Trautmann, Matthias; Wagner, Jutta; Chahin, Maryam; Weinke, Thomas

doi:10.1016/s0163-4453(85)91501-4

Cited by 33 publications

(5 citation statements)

References 13 publications

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“…The implication that penicillin is not as effective as ampicillin has found support in other publications (21)(22)(23), and these publications seemed to confirm the earlier work reporting the effect of penicillin on "listerella" (24) suggesting that "listerella" strains were highly resistant to penicillin when compared to beta-haemolytic streptococci and some other gram-positive organisms. However, the methodology used in this study was not clearly defined and is now suspect in view of other findings.…”

Section: Ampidllin and Penicillinsupporting

confidence: 65%

“…It cannot be assumed that the antimicrobial therapy for bacteraemia and acute meningitis are the same, but ampicillin or penicillin therapy are the antimicrobial treatments most patients receive after the diagnosis of either infection (21,22,31,35,37,(39)(40)(41). However, for the therapy of acute meningitis, dose may be more critical than for the treatment of primary bacteraemia; indeed, some cases of primary bacteraemia even appear to resolve spontaneously without any antimicrobial therapy (35).…”

Section: Ampidllin and Penicillinmentioning

confidence: 99%

“…Problems may then occur as cephalosporins are not generally active against Listeria monocytogenes (22). There are also a number of cases of treatment failure with meningitis (22,31,40,58,73,74), and some patients with Listeria monocytogenes endocarditis and arthritis treated with high dose cephalosporins plus gentamicin have also failed to respond (2,75 …”

Section: Cephalosporinsmentioning

confidence: 99%

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Antimicrobial chemotherapy of human infection due toListeria monocytogenes

Jones¹,

MacGowan²

1995

Eur. J. Clin. Microbiol. Infect. Dis.

100

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Listeriosis is an uncommon infection, but when it occurs it carries a high mortality rate. Early diagnosis is essential and thereafter appropriate antimicrobial chemotherapy. Ampicillin or penicillin plus gentamicin remains the treatment of choice for most manifestations of listeriosis, and adequate doses must be given, i.e. greater than 6g/day of ampicillin or penicillin. Co-trimoxazole appears to be an excellent alternative agent with good penetration into the cerebrospinal fluid. Vancomycin is an appropriate agent for the treatment of primary bacteraemia but does not cross the blood-brain barrier sufficiently well to be useful in meningitis, while erythromycin may be used to treat listeriosis in cases of pregnancy. Treatment of bacteraemia requires one to two weeks' therapy, while meningitis cases may need to be treated for longer; for example, it has been found that most patients with acute meningitis in the UK were treated for 20 days. Infective endocarditis needs treatment for six to eight weeks. Doses should be varied with patients' altered organ function and antimicrobial serum monitoring performed when appropriate.

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Section: Ampidllin and Penicillinsupporting

confidence: 65%

Section: Ampidllin and Penicillinmentioning

confidence: 99%

Section: Cephalosporinsmentioning

confidence: 99%

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Antimicrobial chemotherapy of human infection due toListeria monocytogenes

Jones¹,

MacGowan²

1995

Eur. J. Clin. Microbiol. Infect. Dis.

100

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“…Case reports describe the effectiveness of treating patients who are allergic to penicillin with trimethoprim and sulfamethoxazole (57,143,156); this therapy is bactericidal, and adequate drug levels are found in serum and cerebrospinal fluid (178). Although cephalosporins may be bacteriostatic against L. monocytogenes, treatment failures have been observed (162), and treatment with cephalosporins is not recommended. Duration of therapy for listeriosis has not been standardized.…”

Section: Monocytogenes In Humans Carriagementioning

confidence: 99%

Epidemiology of human listeriosis

1991

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During the 1980s, investigation of several large epidemics of listeriosis confirmed that transmission of L. monocytogenes in food causes human disease. Progress in laboratory detection and subtyping of the organism has enhanced our ability to compare human and environmental isolates of L. monocytogenes. Transmission by foodborne organisms is now recognized as causing both epidemic and sporadic listeriosis. Continued study of dietary risk factors associated with listeriosis is needed in order to develop dietary recommendations for the expanding population at increased risk of disease. Current research application of new molecular methods to the study of L. monocytogenes may improve the ability to diagnose pregnancy-associated disease and permit the rapid detection and control of L. monocytogenes in the food supply.

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“…This is similar to the problem experienced with sensitivity testing of enterococci by disk diffusion. Treatment failures have been documented repeatedly [1,2,25,26] and the use of cephalosporins in known cases of listeriosis is totally contraindicated, There is little information available about the appropriate duration of antibiotic therapy for L. monocytogenes prosthetic joint infection. Regimes similar to that used for patient A lasting 6 weeks appear to be adequate.…”

Section: Discussionmentioning

confidence: 99%

Listeria monocytogenes infection in prosthetic joints

Allerberger

Kasten

Cockerill

et al. 1992

International Orthopaedics

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Listeria monocytogenes is increasingly recognised as a cause of prosthetic joint infection. These infections tend to be more insidious and indolent in contrast to similar infections with Staphylococcus aureus. They can occur in patients who are immunocompromised due to malignancy or other illness or in nonimmunocompromised elderly patients. Listeria infections should not be treated with cephalosporins and prolonged antimicrobial treatment is generally advised for prosthetic joint infections. We noted a high affinity of L. monocytogenes for foreign bodies. Three of twenty-seven cases 11%) of listeriosis under the period of investigation were associated with foreign bodies (hip prosthesis, knee prosthesis and arterial graft).

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Listeria meningitis: Report of ten recent cases and review of current therapeutic recommendations

Cited by 33 publications

References 13 publications

Antimicrobial chemotherapy of human infection due toListeria monocytogenes

Antimicrobial chemotherapy of human infection due toListeria monocytogenes

Epidemiology of human listeriosis

Listeria monocytogenes infection in prosthetic joints

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