Lithium Delays Biochemical Circadian Rhythms in Rats

McEachron, Donald L.; Kripke, Daniel F.; Hawkins, Richard A.; Haus, Erhard; Pavlinac, Dennis; Deftos, Leonard J.

doi:10.1159/000117873

Cited by 70 publications

(15 citation statements)

References 17 publications

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Section: Introductionmentioning

confidence: 99%

“…Among these factors are temperature, barometric pressure, hormones, light, drugs and various toxicants (Sprott, 1967;Ehret et al, 1975;McEachron et al, 1982;Endo et al, 2001;Timofeeva and Gordon, 2002;Kim et al, 2002). It is well-known that various drugs such as caffeine, theophylline, and lithium can affect circadian rhythms (Ehret et al, 1975;McEachron et al, 1982). In fact, various toxicants such as cholinergic neurotoxin, alcohol, acetylcholinesterase inhibitor and cocaine have been reported to cause changes in circadian rhythms and locomotor activity in experimental animals (Endo et al, 2001;Allen, 2005;Timofeeva and Gordon, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Home Cage Locomotion in Cynomolgus Monkeys

Kim

Han

2006

J. Toxicol. Sci.

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-The profiles of home cage locomotor activity and its rhythmicity were investigated using a camera system for 4 consecutive days in cynomolgus monkeys. Nine male and nine female cynomolgus monkeys were used in this study, and were found to have the same profile in nocturnal behavior in that they were mostly inactive during the night. The locomotor activity of both sexes showed a normal activity and inactivity rhythm, which had an inverse relationship between normal activity and inactivity, showing a fluctuation profile of being higher in the light cycle and lower in the dark cycle. The four-day locomotion time of the females was higher than that of the males in the dark period. The females also showed a higher locomotion count and D/L ratio in the dark period than the males during the 4 consecutive days. These findings indicate that the females have greater locomotor activity in the dark period than that of the males. The present findings may serve as useful basic data for the behavioral assessment of overall animal movements in toxicological studies using monkeys.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics of Home Cage Locomotion in Cynomolgus Monkeys

Kim

Han

2006

J. Toxicol. Sci.

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“…Lithium is the mainstay therapy in bipolar affective disorder and is known to influence circadian rhythms with phase delays in experimental animals (McEachron et al 1982) and humans both for normal subjects and bipolar patients (Campbell et al 1989;Bunney and 6.1 + 0.7 9.9 + 1.0 7.8 + 1.1 23.9 + 6.8 21 6.1 + 0.7 14.3 + 2.6 5.1 + 1.0 18.8 + 6.6…”

Section: Resultsmentioning

confidence: 99%

The circadian rhythm of morphine-induced analgesia abolishes after chronic lithium treatment in old mice

Vural

Zengil

2009

Biological Rhythm Research

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The effect of chronic lithium treatment on morphine-induced analgesia was studied in a time-dependent manner in old mice. All mice received lithium chloride via drinking water of 600 mg/l for three weeks. Both basal pain sensitivity and morphine-induced analgesia were determined with a hot-plate test before and after chronic lithium drinking at six different times of the day every four hours. Chronic lithium exposure did not cause any significant change in basal pain sensitivity but the circadian rhythm of morphine analgesia disappeared in old mice. These findings suggest that biological rhythms may alter pharmacokinetic and pharmacodynamic properties of drugs and conversely drugs may alter the rhythmic properties of biological functions. Thus, administration time of drugs should be considered in both experimental designs and clinical settings.

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“…Other substances that have been reported to alter the phase relationship between circadian rhythms and the LD cycle include lithium, clorgyline, and imipramine McEachron et al, 1982;O'Donohue et al, 1982;Wirz-Justice et al, 1982). Tamarkin et al (1983) have obtained particularly good evidence that the continuous administration via osmotic minipumps of clorgyline, an irreversible inhibitor of monoamine oxidase Type A, can induce unstable delays in activity onset of hamsters maintained on an LD 14:10 cycle.…”

Section: Discussionmentioning

confidence: 99%

Entrainment of the Circadian Activity Rhythm to the Light-Dark Cycle Can Be Altered by a Short-Acting Benzodiazepine, Triazolam

Turek

Losee-Olson²

1987

J Biol Rhythms

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The circadian rhythm of locomotor activity in hamsters maintained in either constant darkness or constant light can be phase-shifted by a single injection of the short-acting benzodiazepine, triazolam. These results suggest that treatment with triazolam may also alter the entrainment pattern of circadian rhythms in animals that are synchronized to a light-dark (LD) cycle. To test this hypothesis, hamsters maintained on an LD 6:18 light cycle received daily injections of triazolam (or vehicle) for 10-12 days, and any subsequent effects on the phase relationship between the onset of activity and the LD cycle were determined. Daily injections of triazolam (but not vehicle) induced pronounced advances or delays in the phase relationship between the entrained activity rhythm and the LD cycle; the direction of the shift was dependent on the time of the injection. Taken together with data from previous studies, these results suggest that triazolam, and perhaps other short-acting benzodiazepines, can be used to manipulate the mammalian circadian clock under a variety of experimental conditions.

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Lithium Delays Biochemical Circadian Rhythms in Rats

Cited by 70 publications

References 17 publications

Characteristics of Home Cage Locomotion in Cynomolgus Monkeys

Characteristics of Home Cage Locomotion in Cynomolgus Monkeys

The circadian rhythm of morphine-induced analgesia abolishes after chronic lithium treatment in old mice

Entrainment of the Circadian Activity Rhythm to the Light-Dark Cycle Can Be Altered by a Short-Acting Benzodiazepine, Triazolam

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