Lithium, polyuria and abnormal diurnal weight gain in psychosis

Vieweg, W. Victor R.; Godleski, Linda; Hundley, P. L.; Yank, G. R.

doi:10.1111/j.1600-0447.1988.tb06375.x

Cited by 12 publications

(6 citation statements)

References 13 publications

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“…Lithium use can also result in increased fluid retention. 44 VPA treatment in patients with BD has been associated with weight gain and obesity. 4,45 Weight gain of more than 5% over one year has been reported in 21% of patients receiving VPA compared to 7% in patients receiving placebo.…”

Section: Weight Gain and Obesitymentioning

confidence: 99%

Reproductive and Metabolic Abnormalities Associated with Bipolar Disorder and Its Treatment

Kenna

Jiang

Rasgon

2009

Harvard Review of Psychiatry

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Women with mood disorders, especially bipolar disorder (BD), have been shown to have high rates of reproductive and metabolic dysfunction. The available data on the functional, anatomic, and clinical neuroendocrine abnormalities in women with BD suggest a two-tiered relationship with mood pathology. First, many of the medications commonly used in the treatment of BD can have deleterious effects on blood levels of reproductive hormones and consequently on the hypothalamic-pituitary-gonadal (HPG) axis and reproductive function. Studies that have specifically addressed the association between psychotropic medications and menstrual abnormalities, polycystic ovary syndrome, and overall reproductive endocrine function in women with BD have found high rates of HPG irregularities in women with BD. Second, there is evidence of reproductive dysfunction in women with BD prior to treatment. In addition, many of the psychotropic medications used in the treatment of BD are associated with weight gain, insulin resistance, and dyslipidemia. These metabolic side effects further compound the neuroendocrine system dysregulation in women with BD. Current understanding of the reproductive and metabolic function in women with BD points to vulnerability, which in turn increases the risk of later-life cardiovascular disease and diabetes, among other morbidities, for women with BD.

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Section: Weight Gain and Obesitymentioning

confidence: 99%

Reproductive and Metabolic Abnormalities Associated with Bipolar Disorder and Its Treatment

Kenna

Jiang

Rasgon

2009

Harvard Review of Psychiatry

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“…Approximately 25% of patients using lithium have reported weight gain (Goodwin and Jamison 1990, Silverstone and Romans 1996, Donat Eker and Eker 2011. Etiologically, lithium has been implicated in a variety of causes, such as a direct effect on the hypothalamus or lithium secondary fluid retention (Vieweg et al 1988, Elmslie et al 2001. Especially; patients who were obese before the onset of lithium are at high risk for weight gain with lithium (Bowden et al 2006).…”

Section: B) Metabolic Side Effectsmentioning

confidence: 99%

Lithium Associated Side Effects and Neurotoxicity: Is Lithium Neurotoxicity Related to Iron Deposition?

Altun¹,

Kılıç

Yıldızoğlu

et al. 2019

Psikiyatride Güncel Yaklaşımlar

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Lithium is a mood stabilizer that Australian psychiatrist John Cade and the Swiss Baastrup and Schou's pioneering studies brought in the treatment of bipolar disorder. In current guidelines, it is still considered as first line therapy for acute mania, depression and remission periods. Along with numerous neurotrophic and cytoprotective effects, lithium may rarely cause neurotoxicity. Neuro-toxicity might be related with dose dependent or independent. Mechanism of neurotoxicity has not been identified yet. A possible reason of lithium neurotoxicity is that lithium complicates iron efflux from neurons by inhibiting the tau cascade. Accumulation of iron may increase hydroxyl radical formation, resulting in oxidative neurotoxicity. On the other hand, mechanisms that may alleviate iron deposition should also be considered. This review will address the cardiac and metabolic side effects of lithium and clinical features and biochemical regimes of neurotoxicity, and its relationship with iron accumulation.

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“…[63,64] Bununla birlikte lityuma bağlı sıvı tutulumu da kilo artışı ile sonuçlanmaktadır. [63] Kadınlarda lityuma bağlı kilo artışının daha sıklıkla ortaya çıkması kadın üreme hormonları ile ilişkili bir durumu akla getirmektedir. Fakat Baptista ve arkadaşları hormonal parametreleri değerlendirdikleri bir çalışmada, lityum ile tedavinin, üreme hormonları üzerine etkisi olmadığını göstermişlerdir.…”

Section: Mekanizmasıunclassified

“…Susamanın giderilmesi amacıyla yüksek kalorili içeceklerin tüketilmesi kilo artışına yol açabilir. [63,64] Bununla birlikte lityuma bağlı sıvı tutulumu da kilo artışı ile sonuçlanmaktadır. [63] Kadınlarda lityuma bağlı kilo artışının daha sıklıkla ortaya çıkması kadın üreme hormonları ile ilişkili bir durumu akla getirmektedir.…”

Section: Mekanizmasıunclassified

Lityumun Metabolik Yan Etkileri

Eker¹,

Eker²

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry

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Lithium is an alkaline ion being used since 19th century. After its widespread use in psychiatric disorders, observed side effects caused skepticism about its therapeutic efficacy. Despite several disadvantages, lithium is one of the indispensible drugs used in affective disorders, especially in bipolar disorder. It became a necessity for physicians to recognize its side effects since lithium is still accepted as a gold standard in the treatment of bipolar disorder. Adverse effects of chronic administration of lithium on several organ systems are widely known. In this article metabolic effects of lithium on thyroid and parathyroid glands, body mass index and kidneys will be discussed along with their mechanisms, clinical findings, possible risk factors and treatment. One of the most common side effect of lithium is hypothyroidism. It has the same clinical and biochemical properties as primary hypothyroidism and observed as subclinical hypothyroidism in the first place. Hypothyroidism, even its subclinical form, may be associated with non-response or inadequate response and is indicated as a risk factor for development of rapid cycling bipolar disorder. Therefore, hypothyroidism should be screened no matter how severe it is and should be treated with thyroid hormone in the presence of clinical hypothyroidism. Weight gain due to lithium administration disturbs the compliance to treatment and negatively affects the course of the illness. Increased risk for diabetes, hypertension, ischemic heart disease and stroke because of weight gain constitute other centers of problem. Indeed, it is of importance to determine the risk factors before treatment, to follow up the weight, to reorganize nutritional habits and to schedule exercises. Another frequent problematic side effect of lithium treatment is renal dysfunction which clinically present as nephrogenic diabetes insipidus with the common symptoms of polyuria and polydipsia. Nephrogenic diabetes insipidus develops because of urinary concentration defects due to the detrimental effects of lithium on re-absorption of water and sodium at the level of collector tubules. Close screening of renal functions is very important in the prevention of renal damage during treatment with lithium. Moreover, it is also of importance to screen serum lithium levels as lithium intoxication episodes may increase the risk of renal failure. As a conclusion lithium still preserves its indispensability in affective disorders. Clinicians should have current knowledge about the side effects of lithium and take preventive measures to apply such an important treatment to the patients.

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Lithium, polyuria and abnormal diurnal weight gain in psychosis

Cited by 12 publications

References 13 publications

Reproductive and Metabolic Abnormalities Associated with Bipolar Disorder and Its Treatment

Reproductive and Metabolic Abnormalities Associated with Bipolar Disorder and Its Treatment

Lithium Associated Side Effects and Neurotoxicity: Is Lithium Neurotoxicity Related to Iron Deposition?

Lityumun Metabolik Yan Etkileri

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