Live enhances endothelial cell proliferation without direct contact

Maeno, Nobuaki; Oda, Hiroshi; Yoshiie, Kiyotaka; Wahid, Mohammad Rezwanul; Fujimura, Tsuyoshi; Matayoshi, Seiken

doi:10.1006/mpat.1999.0315

Cited by 76 publications

(68 citation statements)

References 17 publications

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“…This stimulatory effect of GroEL on host cell proliferation is apparently a conserved element in the infection strategy of Bartonella, since lysates generated from B. henselae also showed mitogenic activity, albeit weaker than that of lysates of B. bacilliformis. These results are in line with other reports that B. henselae secretes an antiapoptotic and mitogenic activity into culture supernatants (226,268) that may very well be GroEL. Interestingly, the antiapoptotic activity of these supernatants was weaker than the net effect of live B. henselae, hence confirming the role of additional factors that are known to act on the same phenotype and may account for an attenuation of GroEL potency during evolution (like the VirB/D4 T4SS).…”

Section: The Primary Nichesupporting

confidence: 93%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

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SUMMARY Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. Infections with Bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. Upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted to involve the manipulation of nucleated host cells, e.g., in the microvasculature. Consistently, in vitro research showed that Bartonella harbors an ample arsenal of virulence factors to modulate the response of such cells, gain entrance, and establish an intracellular niche. Subsequently, the bacteria are seeded into the bloodstream where they invade erythrocytes and give rise to a typically asymptomatic intraerythrocytic bacteremia. While this course of infection is characteristic for natural hosts, zoonotic infections or the infection of immunocompromised patients may alter the path of Bartonella and result in considerable morbidity. In this review we compile current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella and discuss their connection to the clinical presentation of human patients, which ranges from minor complaints to life-threatening disease.

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Section: The Primary Nichesupporting

confidence: 93%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

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“…Direct interaction of B. henselae with endothelial cells may result in increased endothelial cell proliferation (Conley et al, 1994;Palmari et al, 1996). The presumptive factor responsible for HUVEC proliferation is suggested to be a bacterial membrane protein (Conley et al, 1994), whereas others have provided evidence for a soluble factor secreted by B. henselae (Maeno et al, 1999). In addition, there is no evidence for VEGF production of B. henselae-infected HUVECs (Maeno et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been described that B. henselae replicates within endothelial cells (Kempf et al, 2000). Moreover, a proliferative effect of B. henselae on endothelial cells has been shown in vitro (Conley et al, 1994;Maeno et al, 1999). However, the molecular basis of the events operating in BA and BP has not yet been established.…”

Section: Introductionmentioning

confidence: 99%

Evidence of a leading role for VEGF inBartonella henselae-induced endothelial cell proliferations

Kempf

Volkmann

Schaller

et al. 2001

Cellular Microbiology

152

184

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“…Bartonella henselae causes vasoproliferative lesions in patients with bacillary angiomatosis and bacillary peliosis (26), and in the context of disease causation, these lesions regress after successful antibiotic treatment (18). On the basis of in vitro infection of human endothelial cell lines, B. henselae has been shown to induce angiogenesis and endothelial cell proliferation (24). Bartonella spp.…”

Section: Case Reportsmentioning

confidence: 99%

Bartonella Species Bacteremia in Two Patients with Epithelioid Hemangioendothelioma

et al. 2011

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Bartonella henselae and B. koehlerae bacteremia was documented in two epithelioid hemangioendothelioma patients and B. koehlerae bacteremia in an asymptomatic partner of one of the patients. Considering the biology and clinically variable natural history of epithelioid hemangioendothelioma, these results suggest that chronic Bartonella infection could have a role in the development of this vascular neoplasm. Bartonella spp. are known to induce vasoproliferative tumors in immunocompromised patients and may play a role in the development of epithelioid hemangioendothelioma in immunocompetent patients.

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Live enhances endothelial cell proliferation without direct contact

Cited by 76 publications

References 17 publications

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

Evidence of a leading role for VEGF inBartonella henselae-induced endothelial cell proliferations

Bartonella Species Bacteremia in Two Patients with Epithelioid Hemangioendothelioma

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