“…This strong need has been the catalyst for algorithms for segmentation and analysis of vasculature. This has been reflected by the large number of proposed algorithms for enhancement, segmentation, and analysis of vasculature and perfusion data from 3D medical images in the past few decades [3,4,5,6,7,8,9,10,11,12]. However, what has been lacking is the existence of benchmarks for the validation, evaluation, and comparison of all these approaches.…”