Liver and kidney concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in cats

Paßlack, Nadine; Mainzer, Barbara; Lahrssen‐Wiederholt, Monika; Schafft, Helmut; Palavinskas, Richard; Breithaupt, Angele; Zentek, Jürgen

doi:10.1186/1746-6148-10-163

Cited by 13 publications

(11 citation statements)

References 25 publications

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“…The risk of negative consequences of both excessive and insufficient Mn in poultry diets is relatively high. Excess Mn accumulates mainly in bone tissue, but also in other organs, such as the liver, kidneys and brain [ 5 – 7 ]. Ionic Mn also interferes with chemical synapse functions and is able to cross the blood—brain barrier, and therefore chronic MN exposure may eventually lead to neurotoxicity and Parkinson-like symptoms [ 8 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of manganese nanoparticles on apoptosis and on redox and immune status in the tissues of young turkeys

et al. 2018

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The aim of the study was to determine whether the use of Mn nanoparticles would make it possible to reduce the level of this micronutrient added to turkey diets without adversely affecting growth performance, antioxidant and immune status, or apoptosis. The experiment was conducted on 6 groups of turkeys with 10 replications in a two-factor design with 3 dosages of manganese, 100, 50 and 10 mg/kg, and 2 sources, manganese oxide (MnO) and manganese nanoparticles (NP-Mn2O3). The study showed that irrespective of the form of Mn used, reducing the Mn level recommended by British United Turkeys for supplementation of the diet of young turkeys from 100 mg/kg to 10 mg/kg increases the content of this element in the blood with no adverse effect on growth performance or the immune system. The reduction in Mn supplementation in the form of NP-Mn2O3 from 100 to 50 and even to 10 mg/kg of turkey diet has no negative effect on antioxidant defence in young turkeys. A 50% reduction of the recommended Mn level in the form of MnO enhances lipid oxidation processes. Replacing MnO with NP-Mn2O3 in the turkey diet probably can increase apoptosis in young turkeys. On the other hand, irrespective of the form of Mn used, reducing supplementation of the turkey diet with this element from 100 to 50 and even to 10 mg/kg probably can reduce apoptosis.

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Section: Introductionmentioning

confidence: 99%

The effect of manganese nanoparticles on apoptosis and on redox and immune status in the tissues of young turkeys

et al. 2018

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“…It is unknown whether the changes in calcium and phosphate metabolism associated with progressive CKD also affect plasma Sr 2+ concentrations. Previously, in animal models with chronic renal failure, signs of increased Sr 2+ concentrations in serum, bone, the liver and the kidneys have been reported . We hypothesize that alterations in mineral metabolism in CKD are associated with increased plasma Sr 2+ concentrations.…”

Section: Introductionmentioning

confidence: 71%

“…Mean BMI was 33 ± 6 kg/ m 2 and in the study population 61% of the patients had a BMI above 30 kg/m 2 . Median duration of diabetes was 11 [7][8][9][10][11][12][13][14][15][16][17][18] years, and the glucose values of the patients were tolerably regulated with a mean HbA 1c of 57 ± 12 mmol/ mol. The majority used insulin (64%).…”

Section: Study Populationmentioning

confidence: 99%

“…Previously, in animal models with chronic renal failure, signs of increased Sr 2+ concentrations in serum, bone, the liver and the kidneys have been reported. [16][17][18] We hypothesize that alterations in mineral metabolism in CKD are associated with increased plasma Sr 2+ concentrations. Whether this subsequently results in increased renal excretion to prevent increased plasma Sr 2+ concentrations has not been studied so far.…”

Section: Introductionmentioning

confidence: 99%

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Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus

Berkhof

Gant

Maatman

et al. 2018

Eur J Clin Investigation

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We found an independent inverse association between eGFR and plasma Sr concentration and an independent association between plasma Sr concentration and plasma FGF23 concentration, a marker of deranged calcium and phosphate metabolism. Further research is needed to determine the mechanisms behind these associations and the impact of an elevation in plasma Sr concentration on bone mineralization and calcification.

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“…It is possible therefore that felids may have lower levels of SOD1 and SOD3 in their kidney per se, which could predispose them to oxidative damage which, over time, progresses toward chronic renal disease. Furthermore, a recent study showed that cats with CKD had lower levels of zinc stored in their kidneys compared to cats without renal disease 61 . However, the zinc content of kidney tissue in the www.nature.com/scientificreports www.nature.com/scientificreports/ current study did not differ with the presence or absence of CIN.…”

Section: Anti-oxidant Minerals Are Low In Cat Versus Dog Kidneys Copmentioning

confidence: 99%

Renal accumulation of prooxidant mineral elements and CKD in domestic cats

Alborough

Grau‐Roma

Brot

et al. 2020

Sci Rep

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felids have a high incidence of chronic kidney disease (cKD), for which the most common renal lesion is chronic interstitial nephritis (cin). cin can be induced by tissue oxidative stress, which is determined by the cellular balance of pro-and anti-oxidant metabolites. Fish-flavoured foods are more often fed to cats than dogs, and such foods tend to have higher arsenic content. Arsenic is a pro-oxidant metallic element. We propose that renal accumulation of pro-oxidant elements such as arsenic and depletion of anti-oxidant elements such as zinc, underpin the high incidence of cin in domestic cats. total arsenic and other redox-reactive metal elements were measured in kidneys (after acid-digestion) and urine (both by inductively-coupled plasma-mass spectrometry) of domestic cats (kidneys, n = 56; urine, n = 21), domestic dogs (kidneys, n = 54; urine, n = 28) and non-domesticated Scottish Wildcats (kidneys, n = 17). Renal lesions were graded by severity of CIN. In our randomly sampled population, CIN was more prevalent in domestic cat versus domestic dog (51%, n = 32 of 62 cats; 15%, 11 of 70 dogs were positive for cin, respectively). cin was absent from all Scottish wildcats. tissue and urinary (corrected for creatinine) arsenic content was higher in domestic cats, relative to domestic dogs and wildcats. Urine arsenic was higher in domestic cats and dogs with cin. Arsenobetaine, an organic and relatively harmless species of arsenic, was the primary form of arsenic found in pet foods. in summary, the kidneys of domestic cats appear to have greater levels of pro-oxidant trace elements, as compared to dogs and wildcats. Since there was no difference in renal arsenic levels in cats with or without CIN, renal arsenic accumulation does not appear a primary driver of excess CIN in cats. Given clear differences in renal handling of pro vs. anti-oxidant minerals between cats and dogs, further in vivo balance studies are warranted. These may then inform species-specific guidelines for trace element incorporation into commercial diets.Chronic kidney disease (CKD) is commonly diagnosed in domestic cats, with a reported prevalence of 1-3% in the overall domestic cat population 1 . One study reported prevalence as high as 50% and 80% in cats of all ages and aged over 15 years, respectively 2 . This contrasts to a reported prevalence of <1% in all dogs 3 and only 10% in dogs over 15 years of age 1 . CKD is defined as the irreversible loss of structure and/or function of one or both kidneys that results from a progressive process occurring over a period of 3 months or more 1 . CKD has various aetiologies, but mononuclear cell tubulointerstitial nephritis -inflammation of the interstitial cells surrounding tubules, predominantly proximal -together with interstitial fibrosis and tubular atrophy is the common histopathological finding in most cases of CKD in cats 4,5 and dogs 6 .Renal tubular epithelial cells are highly metabolically active with high mitochondrial density in order to support oxidative phosphorylation and energy-depe...

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Liver and kidney concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in cats

Cited by 13 publications

References 25 publications

The effect of manganese nanoparticles on apoptosis and on redox and immune status in the tissues of young turkeys

The effect of manganese nanoparticles on apoptosis and on redox and immune status in the tissues of young turkeys

Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus

Renal accumulation of prooxidant mineral elements and CKD in domestic cats

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