Liver Iron Depletion Without Copper Loss in Swine Fed Excess Zinc

Cox, Dennis H.; Hale, O. M.

doi:10.1093/jn/77.3.225

Cited by 31 publications

(18 citation statements)

References 11 publications

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“…Furthermore, the alkaline phosphatase activity of the plasma samples of these animals showed no significant deviations to the control values (unpublished data). This is in agreement with the experimental data of Poulsen [3], and Cox and Hale [19]. They showed that 2000 and 4000 ppm zinc (ZnO) had no adverse effect on the growth and health of weanling pigs.…”

Section: Discussionsupporting

confidence: 90%

Large doses of zinc oxide increases the activity of hydrolases in rats

Szabó

Hegedus

Bruckner

et al. 2004

The Journal of Nutritional Biochemistry

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Section: Discussionsupporting

confidence: 90%

Large doses of zinc oxide increases the activity of hydrolases in rats

Szabó

Hegedus

Bruckner

et al. 2004

The Journal of Nutritional Biochemistry

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“…27 The increases in hepatic, renal, and pancreatic Zn concentrations with increased dietary Zn levels (Table 5) are consistent with numerous reports in the literature. 10,11,15,[20][21][22]26 Zinc begins to accumulate in rat livers at dietary concentrations of 1,000 ppm or more, 9 as was noted in this study. The hepatic and renal Zn concentrations of ferrets suspected of dying from Zn poisoning ranged from 203 to 881 ppm and 785 to 943 ppm (dry weight), respectively.…”

Section: Discussionsupporting

confidence: 67%

“…29 These values are considerably greater than the Zn concentrations observed in comparable tissues from mink fed Zn-supplemented diets in this study (Table 5). Decreases in hepatic and/or renal Cu and/or Fe concentrations with high dietary Zn levels, as reported for rats, 11,21,22,26 swine, 10 and ferrets, 28 were not observed in the mink, suggesting that the Zn-supplemented diets contained sufficient Cu and Fe to negate any evidence of antagonism between these elements.…”

Section: Discussionmentioning

confidence: 50%

Toleration of High Concentrations of Dietary Zinc by Mink

et al. 1991

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Adult and kit male and female natural dark ranch mink (Mustela vison) were fed a conventional diet supplemented with 0, 500, 1,000, or 1,500 ppm zinc, as ZnSO4.7H2O, for 144 days. No marked adverse effects were observed in feed consumption, body weight gains, hematologic parameters, fur quality, or survival. Zinc concentrations in liver, kidney, and pancreas of the mink increased in direct proportion to the zinc content of the diet. Histopathologic examination of the livers, kidneys, and pancreata revealed no lesions indicative of zinc toxicosis. The results indicate that mink can tolerate at least 1,500 ppm dietary zinc, as ZnSO4.7H2O, for several months without apparent adverse effects.

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“…These results are somewhat at variance with results for other species such as rats (Cox and Harris, I960;Magee and Matrone, 1960), swine (Cox and Hale, 1962) and Japanese quail (Hamilton et al, 1979) where excessively high inclusion rates of dietary Zn compounds markedly reduced hepatic Fe contents. However, Jackson et al (1986) have suggested that these anomalous results in the laying hen may be partly explained in terms of the corresponding effects of the different dietary treatments on egg production.…”

Section: Discussioncontrasting

confidence: 56%

Withdrawal of zinc oxide‐containing diets from mature, female domestic fowl: Effects on selected tissue mineral contents

Stevenson

Gibson

Jackson

1987

British Poultry Science

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1. Two hundred and sixteen laying hens of two strains were given diets containing ZnO to provide 0, 0.5, 0.75, 1.00, 1.25, 1.50, 2.00, 3.00 or 4.00 g added Zn/kg. These diets were offered ad libitum for 5 consecutive 28-d periods. All hens were subsequently offered the control diet with no added ZnO for 5 weeks. 2. Four hens from each treatment were killed 0, 1 and 5 weeks after substitution of the ZnO-supplemented diets by the control diet. 3. Dietary addition of ZnO significantly increased liver, kidneys, pancreas and gizzard Zn contents but this effect was rapidly reversed on removal of the ZnO-containing diets. 4. Hepatic and renal Fe contents were significantly depressed by dietary ZnO but after substitution of these diets by the control diet the values were comparable to that of the controls. 5. Liver Cu content declined significantly as dietary ZnO concentration increased but there was a return towards normal after ZnO withdrawal. Renal, pancreatic and gizzard Cu contents showed quadratic responses to added ZnO. 6. After ZnO withdrawal for 5 weeks, pancreas Cu contents declined linearly, whereas renal and gizzard Cu values were similar for all treatments. 7. Overall the long-term feeding of ZnO-supplemented diets followed by a period of withdrawal of the ZnO supplement had no detrimental effects on tissue mineral contents.

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Liver Iron Depletion Without Copper Loss in Swine Fed Excess Zinc

Cited by 31 publications

References 11 publications

Large doses of zinc oxide increases the activity of hydrolases in rats

Large doses of zinc oxide increases the activity of hydrolases in rats

Toleration of High Concentrations of Dietary Zinc by Mink

Withdrawal of zinc oxide‐containing diets from mature, female domestic fowl: Effects on selected tissue mineral contents

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