LncRNA KCNQ1OT1 attenuates sepsis-induced myocardial injury via regulating miR-192-5p/XIAP axis

Sun, Fangyuan; Yuan, Wenbing; Wu, Hao; Chen, Gang; Sun, Yijian; Lin, Yuan; Zhang, Wei; Lei, Ming

doi:10.1177/1535370220908041

Cited by 63 publications

(45 citation statements)

References 39 publications

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“…Due to the nature delivery systems of exosomes between cells, some therapeutic miRNAs can be appropriately packaged in exosomes to target specific recipient cells. Intriguingly, increasing reports indicate that the expression levels of miRNAs are regulated by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) ( Cai et al, 2019 ; Liu et al, 2019 ; Sun et al, 2020 ). Noteworthily, cytoplasmic lncRNAs or circRNAs frequently possess potential sites for binding to certain miRNAs, and can repress miRNA function by acting as miRNA sponges in tumor development ( Shi et al, 2013 ; Kulcheski et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of MiR-192-5p in Human Diseases

et al. 2021

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MicroRNAs (miRNAs) are a type of small non-coding RNAs that play an essential role in numerous biological processes by regulating the post-transcriptional expression of target genes. Recent studies have demonstrated that miR-192-5p, a member of the miR-192 family, partakes in several human diseases, especially various cancers, including cancers of the lung, liver, and breast. Importantly, the levels of miR-192-5p are abundant in biofluids, including the serum and urine, and the exosomal levels of miR-192-5p in circulation can aid in the diagnosis and prognosis of various diseases, such as chronic hepatitis B (CHB) infection disease. Notably, recent studies suggest that miR-192-5p is regulated by long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). However, there are no comprehensive overviews on the role of miR-192-5p in human diseases. This review discusses the significant studies on the role of miR-192-5p in various human diseases, with special emphasis on the diseases of the respiratory and digestive systems.

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Section: Introductionmentioning

confidence: 99%

Emerging Role of MiR-192-5p in Human Diseases

et al. 2021

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“…As a result of this pathway, down-regulation of CYTOR or up-regulation of miR-24 appeared to worsen sepsis-induced myocardial injury via activation of apoptosis. Sun et al demonstrated the role played by lncRNA KCNQ1OT1 in the regulation of miR-192-5p in myocardium damage by sepsis [ 74 ]. KCNQ1OT1 downregulated miR.192-5p, which in turn inhibits the translation of XIAP, improving myocardiocyte viability and contrasting apoptosis.…”

Section: Resultsmentioning

confidence: 99%

“…Some of the aforementioned studies demonstrated that PTEN is targeted by miRNAs in sepsis-induced cardiac damage [ 53 , 59 , 60 ]. A further complication in understanding the role of miRNAs in septic myocardial injury is represented by lncRNAs, as evidenced by some research studies mentioned above [ 45 , 73 , 74 ]. Since they have the property of inhibiting miRNAs, they seem to play a crucial role in the tangled forest of those interconnected signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al 2016 [48] Zhou et al 2017 [51] MiR-155-3p ↑ -Zhang et al [69] MiR-181b-1-3p ↑ -Zhang et al [69] MiR-181b-5p ↓ -Zhang et al [69] MiR-192-5p ↑ its inhibition is protective XIAP Sun et al 2020 [74] MiR-195-3p ↑ -Zhang et al [69] MiR-200a-5p ↑ -Zhang et al [69] MiR-201-5p ↓ -Zhang et al [69] MiR-208a-5p ↑ its inhibition is protective SOCS2 Ouyang et al 2020 [67] MiR-210-3p ↓ -Zhang et al [69] MiR-214 ↑ its up-regulation is protective…”

Section: Pea15a Arrb2mentioning

confidence: 99%

“…Ge et al 2018 [52] MiR-214-3p Sang et al 2020 [53] MiR-218a-5p ↑ -Zhang et al [69] MiR-219a-1-3p ↑ -Zhang et al [69] MiR-223-5p ↓ Sema3A Wang et al 2014 [32] MiR-233-3p ↑ -Zhang et al [69] MiR-233-5p ↑ -Zhang et al [69] MiR-322-5p ↓ -Zhang et al [69] MiR-328 ↑ its inhibition is protective -Sun et al 2020 [68] MiR-330-5p ↑ -Zhang et al [69] ↓ its up-regulation is protective TRAF6 Xing et al 2020 [74] MiR-339-3p ↑ -Zhang et al [69] MiR-340-3p ↑ -Zhang et al [69] MiR-362-5p ↓ -Zhang et al [69] MiR-369-5p ↑ -Zhang et al [69] MiR-378a-5p ↓ -Zhang et al [69] MiR-379-5p ↑ -Zhang et al [69] MiR-380-3p ↑ -Zhang et al [69] MiR-409a-3p ↑ -Zhang et al [69] MiR-425-3p ↓ -Zhang et al [69] MiR-434-5p ↑ -Zhang et al [69] MiR-466b-5p ↑ -Zhang et al [69] MiR-490-5p ↑ -Zhang et al [69] MiR indicates microRNA; HSPA4, the heat shock protein previously known as hsp70; SORBS2, sorbin and SH3 domain containing 2; TGIF1, 5 TG3 -interacting factor 1; PTEN, phosphatase and tensin homolog; TRAF6, tumor necrosis factor receptor-associated factor 6; IκκB, inhibitor of nuclear factor kappa-B kinase subunit beta; XIAP, X-chromosome-linked inhibitor of apoptosis; Nrf2, nuclear factor (erythroid-derived 2)-like 2; SIRT1, sirtuin 1; TRL4, toll-like receptor 4; HMGA2, high mobility group at-hook 2; STX2, syntaxin-2; IRAK1, interleukin-1 receptor-associated kinase 1; ErbB4, erb-B2 receptor tyrosine kinase 4; Akt2, serine/threonine kinase 2; Pea15a, phosphoprotein enriched in astrocytes; Arrb2, β-arrestin 2; SOCS2, suppressor of cytokine signaling 2; Sema3A, semaphorin3A; AQP1, aquaporin 1.…”

Section: Ptenmentioning

confidence: 99%

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MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review

Manetti

Maiese

Paolo

et al. 2020

IJMS

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Sepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids involved in the regulation of gene expression on a post-transcriptional phase, which means they are a part of the epigenetic process. Recently, researchers have found that miRNA expression in tissues and blood differs depending on different conditions. Because of this property, their use as serum sepsis biomarkers has also been explored. A narrative review is carried out to gather and summarize what is known about miRNAs’ influence on cardiac dysfunction during sepsis. When reviewing the literature, we found at least 77 miRNAs involved in cardiac inflammation and dysfunction during sepsis. In the future, miRNAs may be used as early sepsis-induced cardiac dysfunction biomarkers or as new drug targets. This could help clinicians to early detect, prevent, and treat cardiac damage. The potential role of miRNAs as new diagnostic tools and therapeutic strategies worth deepening the complex network between non-coding RNA and biological pathways. Additional studies are needed to further investigate their role in sepsis-induced myocardium injury.

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Potential of long non‐coding RNA KCNQ1OT1 as a biomarker reflecting systemic inflammation, multiple organ dysfunction, and mortality risk in sepsis patients

Jiao¹,

Zhou²,

Wu³

et al. 2021

Clinical Laboratory Analysis

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Background Long non‐coding RNA potassium voltage‐gated channel subfamily Q member 1 opposite strand 1 (lnc‐KCNQ1OT1) represses inflammation and multiple organ dysfunction, whereas its clinical value in sepsis is unclear. Thus, this study aimed to explore this issue. Methods Lnc‐KCNQ1OT1 from peripheral blood mononuclear cells were detected by RT‐qPCR in 116 sepsis patients and 60 healthy controls (HCs). Moreover, sepsis patients were followed‐up until death or up to 28 days. Results Lnc‐KCNQ1OT1 decreased in patients with sepsis than in HCs (p < 0.001). In sepsis patients, lnc‐KCNQ1OT1 was negatively correlated with sequential organ failure assessment (SOFA) scores (r = −0.344, p < 0.001) and several SOFA subscale scores (including respiratory system, coagulation, liver, and renal systems) (all r < 0, p < 0.05). Furthermore, lnc‐KCNQ1OT1 was negatively correlated with CRP (r = −0.386, p < 0.001), TNF‐α (r = −0.332, p < 0.001), IL‐1β (r = −0.319, p < 0.001), and IL‐6 (r = −0.255, p = 0.006). Additionally, lnc‐KCNQ1OT1 levels were lower in sepsis deaths than in sepsis survivors (p < 0.001), and the receiver operating characteristic curve showed that lnc‐KCNQ1OT1 had an acceptable ability to predict 28‐day mortality (area under the curve: 0.780, 95% confidence interval: 0.678–0.882). Meanwhile, its ability to predict 28‐day mortality risk was higher than that of CRP, TNF‐α, IL‐1β, and IL‐6, but slightly lower than the SOFA score and acute physiology and chronic health evaluation II score. Conclusion Lnc‐KCNQ1OT1 serves as a potential biomarker for monitoring disease severity and prognosis in patients with sepsis.

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LncRNA KCNQ1OT1 attenuates sepsis-induced myocardial injury via regulating miR-192-5p/XIAP axis

Cited by 63 publications

References 39 publications

Emerging Role of MiR-192-5p in Human Diseases

Emerging Role of MiR-192-5p in Human Diseases

MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review

Potential of long non‐coding RNA KCNQ1OT1 as a biomarker reflecting systemic inflammation, multiple organ dysfunction, and mortality risk in sepsis patients

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