LncRNA LINC01094 contributes to glioma progression by modulating miR-224-5p/CHSY1 axis

Liu, Luotong; Xu, Qian; Xiong, Ye; Deng, Huajiang; Zhou, Jie

doi:10.1007/s13577-021-00637-6

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…lncRNAs can function as competitive endogenous RNAs (ceRNAs) by sponging miRNAs to regulate gene expression. − According to the subcellular localization of MPFAST, it was inferred that MPFAST might act as a ceRNA and thereby promote the proliferation of BMECs. Combined with the previous lncRNA-seq results and biological information analysis, it was suggested that MPFAST should interact with miR-103 …”

Section: Resultsmentioning

confidence: 99%

“…A large number of lncRNAs have been reported to function as competitive endogenous RNAs (ceRNAs) and regulate gene expression through sponging microRNAs (miRNAs). − lncRNAs can sponge miRNAs to inhibit the migration, invasion, and proliferation of breast cancer cells. lncRNA-p21 increased the expression of P 21 through sponge absorption of miR-17-5P, thereby inducing cell cycle arrest and inhibiting cell proliferation .…”

Section: Introductionmentioning

confidence: 99%

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lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway

Liu

Sun

Zhang

et al. 2022

J. Agric. Food Chem.

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Long noncoding RNAs (lncRNAs) have an essential role in mammary gland development and lactation. Our earlier study showed that the lncRNA mammary proliferation and fatty acid synthesis-associated transcript (MPFAST) is highly expressed in the Holstein cow mammary gland during the middle lactation period compared to the dry period, which indicates its potential role in lactation. Therefore, gain- and loss-of-function experiments were performed on bovine mammary epithelial cells (BMECs) by cell counting kit 8 (CCK8), 5-ethynyl-2′-deoxyuridine (EdU), real-time quantitative polymerase chain reaction (RT-qPCR), and western blot. The results indicated that MPFAST promoted the viability and proliferation of BMECs. The oil red O staining and cellular triglyceride assay further showed that MPFAST promoted the number of lipid droplets and cellular triglyceride synthesis in BMECs. Bioinformatics analysis showed that MPFAST could act as a molecular sponge for miR-103, and PIK3R1 was a potential target of miR-103, which was further confirmed by the dual-luciferase reporter assay, RT-qPCR, and western blot. The overexpression of MPFAST promoted the expression of PIK3R1 at mRNA and protein levels. It also significantly increased the mRNA relative expression levels of AKT, mTOR, and SREBP1, and the protein relative expression levels of AKT and p-AKT in the PI3K-AKT signaling pathway. In contrast, the inhibition of MPFAST resulted in the downregulation of the PI3K-AKT signaling pathway genes. These results indicated that MPFAST regulates the expression of the genes in the PI3K-AKT signaling pathway through sponging miR-103 and promotes the proliferation and synthesis of fatty acids of BMECs. Our results would provide a new direction for further exploring the regulatory mechanism of lncRNA in the mammary gland.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway

Liu

Sun

Zhang

et al. 2022

J. Agric. Food Chem.

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“…In addition, Tuersong et al obtained similar results, pointing out that AL513123.1 in BRCA may be involved in the regulation of the complex ceRNA network and identified as a potential prognostic biomarker and therapeutic target for BRCA diagnosis and treatment ( Tuersong et al, 2019 ). LINC01094 is associated with the prognosis of ovarian cancer, pancreatic cancer, glioma, and renal clear cell carcinoma ( Xu et al, 2020a ; Jiang et al, 2020 ; Chen et al, 2021b ; Luo et al, 2021 ; Liu et al, 2022 ). Li et al found that AL356417.2, as an immune-related lncRNA in BRCA, is closely associated with the prognosis of BRCA and can be used as a prognostic molecular marker and immunotherapy target for BRCA patients ( Li et al, 2020b ).…”

Section: Discussionmentioning

confidence: 99%

Screening and validation of platelet activation-related lncRNAs as potential biomarkers for prognosis and immunotherapy in gastric cancer patients

et al. 2022

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Background: Platelets (PLT) have a significant effect in promoting cancer progression and hematogenous metastasis. However, the effect of platelet activation-related lncRNAs (PLT-related lncRNAs) in gastric cancer (GC) is still poorly understood. In this study, we screened and validated PLT-related lncRNAs as potential biomarkers for prognosis and immunotherapy in GC patients.Methods: We obtained relevant datasets from the Cancer Genome Atlas (TCGA) and Gene Ontology (GO) Resource Database. Pearson correlation analysis was used to identify PLT-related lncRNAs. By using the univariate, least absolute shrinkage and selection operator (LASSO) Cox regression analyses, we constructed the PLT-related lncRNAs model. Kaplan-Meier survival analysis, univariate, multivariate Cox regression analysis, and nomogram were used to verify the model. The Gene Set Enrichment Analysis (GSEA), drug screening, tumor immune microenvironment analysis, epithelial-mesenchymal transition (EMT), and DNA methylation regulators correlation analysis were performed in the high- and low-risk groups. Patients were regrouped based on the risk model, and candidate compounds and immunotherapeutic responses aimed at GC subgroups were also identified. The expression of seven PLT-related lncRNAs was validated in clinical medical samples using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Results: In this study, a risk prediction model was established using seven PLT-related lncRNAs -(AL355574.1, LINC01697, AC002401.4, AC129507.1, AL513123.1, LINC01094, and AL356417.2), whose expression were validated in GC patients. Kaplan-Meier survival analysis, the receiver operating characteristic (ROC) curve analysis, univariate, multivariate Cox regression analysis verified the accuracy of the model. We screened multiple targeted drugs for the high-risk patients. Patients in the high-risk group had a poorer prognosis since low infiltration of immune killer cells, activation of immunosuppressive pathways, and poor response to immunotherapy. In addition, we revealed a close relationship between risk scores and EMT and DNA methylation regulators. The nomogram based on risk score suggested a good ability to predict prognosis and high clinical benefits.Conclusion: Our findings provide new insights into how PLT-related lncRNAs biomarkers affect prognosis and immunotherapy. Also, these lncRNAs may become potential biomarkers and therapeutic targets for GC patients.

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“…Katsushima et al reported that TUG1 was specifically activated by Notch1 in GSCs coordinately potentiating GSC self-replication maintenance by sponging miR-145 in the cytoplasm and recruiting polycomb protein complexes to repress the expression of serval differentiation genes ( Katsushima et al, 2016 ) ( Figure 3B ). Liu et al (2021) reported that PCGEM1 inhibition repressed GBM cell proliferation, migration, invasion, and tumor growth in vivo by promoting CDK6 expression by quenching miR-539-5p. Deguchi et al (2017) revealed that ECONEXIN as a novel oncogene promotes TOP2A expression by quenching miR-411-5p, which potentiates glioma cell proliferation.…”

Section: Generally Molecular Basis Of Lncrnasmentioning

confidence: 99%

“… Deguchi et al (2017) revealed that ECONEXIN as a novel oncogene promotes TOP2A expression by quenching miR-411-5p, which potentiates glioma cell proliferation. In addition, recent studies reported that LINC01094 ( Liu et al, 2022 ), DGCR5 ( He et al, 2020a ), NFIA-AS2 ( Xin et al, 2020 ), HANR ( Wang et al, 2020d ), LINC00355 ( Qi et al, 2021 ), and ZFPM2-AS1 ( Zhang et al, 2021 ) were involved in regulating GBM progression by quenching miR-224-5p, miR-21 and miR-23a, miR-655-3p, miRNA-335, miR-1225, and miR-515-5p, respectively. It is worth stating that numerous other functional lncRNAs, including HOTAIR, GAS5, and CASC2, are able to regulate GBM malignant progression by functioning as ceRNA to quench miRNA activity, which has also been reported elsewhere ( Peng et al, 2018b ; Cheng et al, 2020a ; Stackhouse et al, 2020 ).…”

Section: Generally Molecular Basis Of Lncrnasmentioning

confidence: 99%

Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

Liu

Chen

Wang

et al. 2022

Front. Cell Dev. Biol.

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Glioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients. Thus, there is an urgent requirement to characterize more biomarkers for the early diagnosis of GBM patients. In addition, the detailed molecular basis during GBM pathogenesis and oncogenesis is not fully understood, highlighting that it is of great significance to elucidate the molecular mechanisms of GBM initiation and development. Recently, accumulated pieces of evidence have revealed the central roles of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of GBM by binding with DNA, RNA, or protein. Targeting those oncogenic lncRNAs in GBM may be promising to develop more effective therapeutics. Furthermore, a better understanding of the biological function and underlying molecular basis of dysregulated lncRNAs in GBM initiation and development will offer new insights into GBM early diagnosis and develop novel treatments for GBM patients. Herein, this review builds on previous studies to summarize the dysregulated lncRNAs in GBM and their unique biological functions during GBM tumorigenesis and progression. In addition, new insights and challenges of lncRNA-based diagnostic and therapeutic potentials for GBM patients were also introduced.

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LncRNA LINC01094 contributes to glioma progression by modulating miR-224-5p/CHSY1 axis

Cited by 11 publications

References 35 publications

lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway

lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway

Screening and validation of platelet activation-related lncRNAs as potential biomarkers for prognosis and immunotherapy in gastric cancer patients

Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

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