“…One study found that lncRNA OIP5-AS1 was significantly downregulated in cisplatin-induced AKI model both in vitro and in vivo . Further research revealed that OIP5-AS1 could reduce the apoptosis of cisplatin-stimulated renal epithelial cells to exert a protective effect by targeting the miR-144-5p/PKM2 axis ( Chang et al, 2021a ). Similarly, the novel lncRNA XLOC_032768 and PRNCR1 could also perform a similar role of reducing cisplatin-induced apoptosis of renal tubular epithelial cells to protect against the cisplatin-induced AKI through TNF-α and miR-182-5p/EZH1, respectively ( Zhou et al, 2020 ; Li et al, 2021a ).…”
Section: Lncrna Of Aki Induced By Other Causesmentioning
Acute kidney injury (AKI) is a global public health concern with high morbidity, mortality, and medical costs. Despite advances in medicine, effective therapeutic regimens for AKI remain limited. Long non-coding RNAs (lncRNAs) are a subtype of non-coding RNAs, which longer than 200 nucleotides and perform extremely diverse functions in biological processes. Recently, lncRNAs have emerged as promising biomarkers and key mediators to AKI. Meanwhile, existing research reveals that the aberrant expression of lncRNAs has been linked to major pathological processes in AKI, including the inflammatory response, cell proliferation, and apoptosis, via forming the lncRNA/microRNA/target gene regulatory axis. Following a comprehensive and systematic search of the available literature, 87 relevant papers spanning the years 2005 to 2021 were identified. This review aims to provide and update an overview of lncRNAs in AKI, and further shed light on their potential utility as AKI biomarkers and therapeutic targets.
“…One study found that lncRNA OIP5-AS1 was significantly downregulated in cisplatin-induced AKI model both in vitro and in vivo . Further research revealed that OIP5-AS1 could reduce the apoptosis of cisplatin-stimulated renal epithelial cells to exert a protective effect by targeting the miR-144-5p/PKM2 axis ( Chang et al, 2021a ). Similarly, the novel lncRNA XLOC_032768 and PRNCR1 could also perform a similar role of reducing cisplatin-induced apoptosis of renal tubular epithelial cells to protect against the cisplatin-induced AKI through TNF-α and miR-182-5p/EZH1, respectively ( Zhou et al, 2020 ; Li et al, 2021a ).…”
Section: Lncrna Of Aki Induced By Other Causesmentioning
Acute kidney injury (AKI) is a global public health concern with high morbidity, mortality, and medical costs. Despite advances in medicine, effective therapeutic regimens for AKI remain limited. Long non-coding RNAs (lncRNAs) are a subtype of non-coding RNAs, which longer than 200 nucleotides and perform extremely diverse functions in biological processes. Recently, lncRNAs have emerged as promising biomarkers and key mediators to AKI. Meanwhile, existing research reveals that the aberrant expression of lncRNAs has been linked to major pathological processes in AKI, including the inflammatory response, cell proliferation, and apoptosis, via forming the lncRNA/microRNA/target gene regulatory axis. Following a comprehensive and systematic search of the available literature, 87 relevant papers spanning the years 2005 to 2021 were identified. This review aims to provide and update an overview of lncRNAs in AKI, and further shed light on their potential utility as AKI biomarkers and therapeutic targets.
“…In this issue of the Biomedical Journal , Chang et al provide us with an insight into the relationship between long non-coding RNA (lncRNA) Opa interacting protein 5-antisense RNA 1 (OIP5-AS1) and the progress of AKI. [ 11 ].…”
Section: Spotlight On Reviewsmentioning
confidence: 99%
“…miR-144-5p is one miRNA whose aberrant expression is involved in tumorigenesis. [ 11 , [15] , [16] , [17] ] (see Figure 1 ) Figure 1 The involvement of miRNA-144-5p in human cancer. miRNA-144-5p has a binding relationship to the lncRNA OIP5-AS1 that is known for sponging miRNAs (competing endogenous RNA).…”
Section: Spotlight On Reviewsmentioning
confidence: 99%
“…OIP5-AS1 was significantly downregulated in AKI mice and its overexpression promoted cell growth while reducing apoptosis in human renal tubular HK-2 cells. [ 11 ].…”
“…However, enhancing miR-205-5p expression suppressed apoptotic rate [ 72 ]. The levels of miR-144-5p were also downregulated in DDP-stimulated HK-2 cells, and the expression levels of apoptosis-related proteins showed that enhancing miR-144-5p expression was able to increase the expression levels of caspase-3/-9, and Bax, and to decrease the expression levels of Bcl-2, by regulating PKM2 expression [ 71 ]. Opposite results were observed by Zhang et al [ 70 ], since they demonstrated that remote ischemic preconditioning, a strategy to induce resistance in a target organ, exerted a protective effect on DDP-induced AKI in mice by reversing the downregulation of miR-144 and the dysregulation of caspase-3, Bax, and Bcl-2 expression in renal tissues of DDP-induced AKI in mice and NRK-52 cells.…”
Section: Involvement Of Micrornas Upon Intrinsic Apoptosis Pathway Du...mentioning
Cisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in DDP-induced nephrotoxicity. Noncoding RNAs (ncRNAs), a class of epigenetic processes, are molecules that regulate gene expression under physiological and pathological conditions. MicroRNAs (miRNAs) are the most characterized class of ncRNAs and are engaged in many cellular processes. In this review, we describe how different miRNAs regulate some pathways leading to cell death by apoptosis, specifically the intrinsic apoptosis pathway. Accordingly, many classes of natural products have been tested for their ability to prevent DDP-induced apoptosis. The study of epigenetic regulation for underlying cell death is still being studied, which will allow new strategies for the diagnosis and therapy of this unwanted disease, which is presented as a side effect of antineoplastic treatment.
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