LncRNA PVT1 accelerates LPS-induced septic acute kidney injury through targeting miR-17-5p and regulating NF-κB pathway

Yuan, Wensheng; Xiong, Xiao-Qing; Du, Jinlong; Fan, Qi; Wang, Rong; Zhang, Xia

doi:10.1007/s11255-021-02905-8

Cited by 18 publications

(11 citation statements)

References 28 publications

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“…LncRNAs are a diverse family of non-coding RNAs (ncRNAs). They encompass different ncRNAs like miRNAs, LncRNAs, snRNAs and CircRNAs ( 65 ).LncRNAs’ transcripts are longer than 200 nucleotides and are involved in the pathophysiology of many diseases ( 66 ). Relevant studies have pointed out that the number of human lncRNAs exceeds the number of protein-coding genes ( 67 ).…”

Section: Expression and Roles Of Lncrnas In Mdscsmentioning

confidence: 99%

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

et al. 2023

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Lung tumours are widespread pathological conditions that attract much attention due to their high incidence of death. The immune system contributes to the progression of these diseases, especially non-small cell lung cancer, resulting in the fast evolution of immune-targeted therapy. Myeloid-derived suppressor cells (MDSCs) have been suggested to promote the progression of cancer in the lungs by suppressing the immune response through various mechanisms. Herein, we summarized the clinical studies on lung cancer related to MDSCs. However, it is noteworthy to mention the discovery of long non-coding RNAs (lncRNAs) that had different phenotypes and could regulate MDSCs in lung cancer. Therefore, by reviewing the different phenotypes of lncRNAs and their regulation on MDSCs, we summarized the lncRNAs’ impact on the progression of lung tumours. Data highlight LncRNAs as anti-cancer agents. Hence, we aim to discuss their possibilities to inhibit tumour growth and trigger the development of immunosuppressive factors such as MDSCs in lung cancer through the regulation of lncRNAs. The ultimate purpose is to propose novel and efficient therapy methods for curing patients with lung tumours.

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Section: Expression and Roles Of Lncrnas In Mdscsmentioning

confidence: 99%

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

et al. 2023

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“…For example, PVT1 has been widely investigated as a miRNA sponge in multiple cancers and other non-HIV related studies. In these studies, a number of miRNAs that promote HIV latency were shown to be sponged by PVT1: miR-186, [87][88][89] miR-27b, 90 miR-17-5p, 91,92 miR-20a, 93 and miR-125b. 94 Since these miRNAs promote HIV latency, targeting their interaction with PVT1 may result in driving the provirus into a deeper silent state.…”

Section: Lncrna Perspectivesmentioning

confidence: 99%

An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review

Ramirez¹,

Pantoja²,

Beliakova-Bethell³

2023

HIV

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The existence of latent cellular reservoirs is recognized as the major barrier to an HIV cure. Reactivating and eliminating "shock and kill" or permanently silencing "block and lock" the latent HIV reservoir, as well as gene editing, remain promising approaches, but so far have proven to be only partially successful. Moreover, using latency reversing agents or "block and lock" drugs pose additional considerations, including the ability to cause cellular toxicity, a potential lack of specificity for HIV, or low potency when each agent is used alone. RNA molecules, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are becoming increasingly recognized as important regulators of gene expression. RNA-based approaches for combatting HIV latency represent a promising strategy since both miRNAs and lncRNAs are more cell-type and tissue specific than protein coding genes. Thus, a higher specificity of targeting the latent HIV reservoir with less overall cellular toxicity can likely be achieved. In this review, we summarize current knowledge about HIV gene expression regulation by miRNAs and lncRNAs encoded in the human genome, as well as regulatory molecules encoded in the HIV genome. We discuss both the transcriptional and post-transcriptional regulation of HIV gene expression to align with the current definition of latency, and describe RNA molecules that either promote HIV latency or have antilatency properties. Finally, we provide perspectives on using each class of RNAs as potential targets for combatting HIV latency, and describe the complexity of the interactions between different RNA molecules, their protein targets, and HIV.

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“…One study found that miR-17-5p levels were decreased in the serum of AKI patients and HK-2 cells induced by LPS. In addition, TNF-α, IL-6 and IL-1 were severely decreased in LPS-activated HK-2 cells that were transfected with miR-17-5p [ 104 ]. Similarly, miR-942-5p expression was reduced in HK-2 cells that were treated with LPS, and the overexpression of miR-942-5p inhibited LPS-induced inflammation and apoptosis in HK-2 cells via targeting FOXO3 [ 105 ].…”

Section: Reviewmentioning

confidence: 99%

MicroRNAs in septic acute kidney injury

Wang

et al. 2023

Burns &Amp; Trauma

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Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological processes. Emerging evidence has shown that miRNAs are intimately associated with septic AKI. The goal of this review was to summarize recent advances in the profound understanding of the functional role of miRNAs in septic AKI, as well as to provide new insights into miRNAs as feasible biomarkers and therapeutic targets for septic AKI.

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LncRNA PVT1 accelerates LPS-induced septic acute kidney injury through targeting miR-17-5p and regulating NF-κB pathway

Cited by 18 publications

References 28 publications

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review

MicroRNAs in septic acute kidney injury

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