2021
DOI: 10.1080/21655979.2021.1982323
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LncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis

Abstract: Osteoporosis (OP) is a systemic bone metabolic disease. Promotion of osteoblast proliferation and inhibition of cell apoptosis may be helpful for the prevention and clinical treatment of OP. In the current study, we focused on the expression changes and clinical values of lncRNA ROR and miR-145-5p in OP clinical serum samples, and investigated the interactive modulation effect of ROR/ miR-145-5p on osteoblast function. Serum samples were obtained from 82 OP patients and 79 healthy individuals. MC3T3-E1 was app… Show more

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Cited by 34 publications
(24 citation statements)
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“…As osteoporosis is a common age-related disease, many studies have focused on therapeutic strategies for its treatment. Fu Y et al demonstrated that the LncRNA ROR/miR-145-5p axis modulates osteoblasts proliferation and apoptosis in osteoporosis [ 33 ]. In future work, the therapeutic function of Omarigliptin against Osteoporosis will be researched by treating the Osteoporosis animal model using the applicable doses.…”
Section: Discussionmentioning
confidence: 99%
“…As osteoporosis is a common age-related disease, many studies have focused on therapeutic strategies for its treatment. Fu Y et al demonstrated that the LncRNA ROR/miR-145-5p axis modulates osteoblasts proliferation and apoptosis in osteoporosis [ 33 ]. In future work, the therapeutic function of Omarigliptin against Osteoporosis will be researched by treating the Osteoporosis animal model using the applicable doses.…”
Section: Discussionmentioning
confidence: 99%
“…Then real-time PCR was conducted with the assistance of SYBR GreenPCR reagent and ABI7500FAST Real-Time PCR (MedChemExpress, NJ, USA). The 2 −ΔΔCT approach was utilized to assess the relative profiles of lncRNA PURPL, miR-137, and ZBTB7A (U6 and GAPDH were taken as internal references) [ 29 ]. Primer sequences are detailed below:…”
Section: Methodsmentioning
confidence: 99%
“…Human bone marrow mesenchymal stem cell proliferation was detected by a CCK-8 assay (Beyotime, Shanghai, China) as previously described [ 17 ]. The hBMSCs were cultured in a 96-well plate at a density of 1 × 10 5 cells/mL.…”
Section: Methodsmentioning
confidence: 99%