2021
DOI: 10.1016/j.intimp.2020.107150
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LncRNA SNHG7 alleviates IL-1β-induced osteoarthritis by inhibiting miR-214-5p-mediated PPARGC1B signaling pathways

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Cited by 40 publications
(23 citation statements)
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“…This study also revealed that mechanistically, miR-214-3p promotes bone resorption through direct targeting of TNF-α Receptor Associated Factor 3 (TRAF3), and osteoclast-targeted treatment of Traf3 3 UTR plasmid attenuated excessive bone resorption in OC-miR-214-3p mice. In addition, miR-214 is decreased by TNF-α in HT29 colorectal adenocarcinoma cells , induced by IL-1β in primary chondrocytes (Xu et al, 2021) and induced by IL-6 in human colonocytes (Polytarchou et al, 2015). This regulation of miR-214 expression by inflammatory cytokines suggests potential roles for miR-214 in inflammatory bone metabolism.…”
Section: Mir-214mentioning
confidence: 88%
“…This study also revealed that mechanistically, miR-214-3p promotes bone resorption through direct targeting of TNF-α Receptor Associated Factor 3 (TRAF3), and osteoclast-targeted treatment of Traf3 3 UTR plasmid attenuated excessive bone resorption in OC-miR-214-3p mice. In addition, miR-214 is decreased by TNF-α in HT29 colorectal adenocarcinoma cells , induced by IL-1β in primary chondrocytes (Xu et al, 2021) and induced by IL-6 in human colonocytes (Polytarchou et al, 2015). This regulation of miR-214 expression by inflammatory cytokines suggests potential roles for miR-214 in inflammatory bone metabolism.…”
Section: Mir-214mentioning
confidence: 88%
“…In addition, lncRNA TUG1/miR-195/MMP-13 axis facilitates the degradation of chondrocyte extracellular matrix induced by OA [ 33 ]. LncRNA SNHG7 absorbs miR-214-5p to modulate PPARGC1B pathways and improves IL-1β-induced OA [ 34 ]. Moreover, lncRNA MEG3 targets miR-93/TGFBR2 axis to retard extracellular matrix degradation in OA [ 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…the PPARg pathway and combating the cytotoxic impact of miR-214-5p (45). The protective effects of other lncRNAs against OA are summarized in Table 2.…”
Section: Lncrnas In Osteoarthritismentioning
confidence: 99%
“…SNHG7 is another down-regulated lncRNA in OA. This lncRNA sponges miR-34a-5p and miR-214-5p ( 44 , 45 ). Due to its sponging effects on miR-34a-5p, down-regulation of SNHG7 results in down-regulation of SYVN1, the direct target of this miRNA.…”
Section: Lncrnas In Osteoarthritismentioning
confidence: 99%