Load-deformation characteristics of acellular human scalp: assessing tissue grafts from a material testing perspective

Zwirner, Johann; Ondruschka, Benjamin; Scholze, Mario; Schulze‐Tanzil, Gundula; Hammer, Niels

doi:10.1038/s41598-020-75875-z

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…One clamp was used for each side. Deviating from previous interlocking two-part designs [18][19][20][21], this new setup involved a single squeezing part with a central opening. The clamps consisted of a pattern of small 4-sided pyramids (design with flat pyramids, pyramid height = 0.75 mm, diagonal base = 2.12 mm).…”

Section: Methodsmentioning

confidence: 99%

Fatigue Testing of Human Flexor Tendons Using a Customized 3D-Printed Clamping System

et al. 2022

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Improved surgical procedures and implant developments for ligament or tendon repair require an in-depth understanding of tissue load-deformation and fatigue properties. Cyclic testing will provide crucial information on the behavior of these materials under reoccurring loads and on fatigue strength. Sparse data are available describing soft tissue behavior under cyclic loading. To examine fatigue strength, a new technology was trialed deploying 3D-printing to facilitate and standardize cyclic tests aiming to determine tendon fatigue behavior. Cadaveric flexor digitorum tendons were harvested and mounted for tensile testing with no tapering being made, using 3D-printed clamps and holder arms, while ensuring a consistent testing length. Loads ranging between 200 to 510 N were applied at a frequency of 4 Hz, and cycles to failure ranged between 8 and >260,000. S–N curves (Woehler curves) were generated based on the peak stresses and cycles to failure. Power regression yielded a combined coefficient of determination of stress and cycles to failure of R2 = 0.65, while the individual coefficients for tissues of single donors ranged between R2 = 0.54 and R2 = 0.88. The here-presented results demonstrate that S–N curves of human tendons can be obtained using a standardized setting deploying 3D-printing technology.

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Section: Methodsmentioning

confidence: 99%

Fatigue Testing of Human Flexor Tendons Using a Customized 3D-Printed Clamping System

et al. 2022

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“…In general, since the surgical sites of the stapedectomy and stapedotomy are closed or filled with fascia or fat, the properties of the closing materials in the simulations were determined as those of fascia or fat. According to previous studies, the Young's modulus of the fascia was reported to be in the range of 1-24 MPa (Trindade et al, 2012;Zwirner et al, 2020) whereas that of fat was reported to be about 1 kPa (Comley and Fleck, 2010a,b). In Figures 2B, D, the center of the prosthesis and footplate could be not perfectly aligned according to the calculation method to find the center of the asymmetric-oval shape.…”

Section: Stapes Tendonmentioning

confidence: 98%

“…3.8 × 10 3 (Gan et al, 2004) 1.2 × 10 3 (Homma et al, 2010) 0.15 Incus ligament 4.8 (Gan et al, 2004) 1.2 × 10 3 (Homma et al, 2010) 0.15 Tympanic membrane, pars tensa 2 × 10 1 (Homma et al, 2010) 1.2 × 10 3 (Koike et al, 2002) 0.7 Tympanic membrane, pars flaccida 7 (Homma et al, 2010) 1.2 × 10 3 (Koike et al, 2002) 0.15 Tympanic annulus 0.6 (Koike et al, 2002) 1.2 × 10 3 (Homma et al, 2010) 0.5 Stapes annular ligament 0.7 (Kim et al, 2014) 1.2 × 10 3 (Homma et al, 2010) 0.3 Round window 0.05 (Kim et al, 2014) 1.2 × 10 3 (Kim et al, 2014) 0.8 Cochlear bone 20 × 10 3 (Turner et al, 1999) 1.8 × 10 3 (Peterson and Dechow, 2003) 0.3 Cochlear fluid 1,500 [m/s; sound speed] ( Levin et al, 1981) 1 × 10 3 (Levin et al, 1981) 0.1 Basilar membrane 6.5-5.5 (longitudinally from base to apex) 0.2-1 × 10 3 (transversely from base to apex) (Kim et al, 2014) 1 × 10 3 (Kim et al, 2014) 0.3 Prosthesis 150 × 10 3 (Salvinelli et al, 2009) 21 × 10 3 (Salvinelli et al, 2009) 0.01 Closing materials 0.001, 1, 24 (Comley and Fleck, 2010a,b;Trindade et al, 2012;Zwirner et al, 2020) 1.2 × 10 3 (Ward and Lieber, 2005) 0.3…”

Section: Stapes Tendonmentioning

confidence: 99%

Effect of closing material on hearing rehabilitation in stapedectomy and stapedotomy: A finite element analysis

Lim

Goo²,

Kang³

et al. 2023

Front. Neurosci.

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Stapedotomy or stapedectomy operations are often performed to treat otosclerosis. During the operation, the space created by bone removal is usually filled with a closing material such as fat or fascia. In this study, the effect of the Young’s modulus of the closing material on the hearing level was investigated through the 3D finite element model of a human head including auditory periphery. The Young’s moduli of the closing material used to implement stapedotomy and stapedectomy conditions in the model were varied from 1 kPa to 24 MPa. The results showed that the hearing level improved when the closing material was more compliant after stapedotomy. Therefore, when the stapedotomy was performed using fat whose Young’s modulus is lowest among the potential closing materials, the hearing level recovered the best among all simulated cases. On the other hand, in stapedectomy, the Young’s modulus did not have the linear relationship between the hearing level and the compliance of the closing material. Hence, the Young’s modulus causing the best hearing rehabilitation in stapedectomy was found not at the end of the investigated range of Young’s modulus but somewhere in the middle of the given range.

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“…Inaccurate assessment of sample cross-sectional area can result in significant errors in the calculation of experimental tensile stresses and can thus influence experimentally-derived tissue mechanical properties. 92 Consequently, future studies should focus on the use of noncontact photogrammetry methods 37 or laser scanning methods 93,94 to determine sample cross-sectional area.…”

Section: Measurement Of Sample Geometries For Sample Stress Evaluationmentioning

confidence: 99%

Mechanical Properties of the Cranial Meninges: A Systematic Review

Walsh

Zhou

et al. 2021

Journal of Neurotrauma

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The meninges are membranous tissues which are pivotal in maintaining homeostasis of the central nervous system. Despite the importance of the cranial meninges in nervous system physiology and in head injury mechanics, our knowledge of the tissues' mechanical behaviour and structural composition is limited. This systematic review analyses the existing literature on the mechanical properties of the meningeal tissues. Publications were identified from a search of Scopus, Academic Search Complete and Web of Science and screened for eligibility according to PRISMA guidelines. The review details the wide range of testing techniques employed to date and the significant variability in the observed experimental findings. Our findings identify many gaps in the current literature which can serve as a guide for future work for meningeal mechanics investigators. The review identifies no peer-reviewed mechanical data on the falx and tentorium tissues, both of which have been identified as key structures in influencing brain injury mechanics. A dearth of mechanical data for the pia-arachnoid complex was also identified (no experimental mechanics studies on the human pia-arachnoid complex were identified), which is desirable for biofidelic modelling of human head injuries. Finally, this review provides recommendations on how experiments can be conducted to allow for standardisation of test methodologies, enabling simplified comparisons and conclusions on meningeal mechanics.

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Load-deformation characteristics of acellular human scalp: assessing tissue grafts from a material testing perspective

Cited by 8 publications

References 27 publications

Fatigue Testing of Human Flexor Tendons Using a Customized 3D-Printed Clamping System

Fatigue Testing of Human Flexor Tendons Using a Customized 3D-Printed Clamping System

Effect of closing material on hearing rehabilitation in stapedectomy and stapedotomy: A finite element analysis

Mechanical Properties of the Cranial Meninges: A Systematic Review

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