Highly efficient switch-mode class-E Power Amplifiers (PAs) are sensitive to load impedance variations. For Voltage Standing Wave Ratios (VSWRs) up to 10:1, the peak switch voltage and average switch current can increase by a factor 1.7 and 2.5, respectively, relative to those under nominal load conditions, imposing serious reliability risks. This work describes a technique to self-protect class-E PAs to decrease their sensitivity to load variations, relying on tuning of the switch-tank relative-resonance frequency, implemented by an on-chip Switched-Capacitor Bank (SCB). To validate the technique, load-pull measurements are conducted on a class-E PA implemented in a standard 65 nm CMOS technology, employing an off-chip matching network, augmented with a fully automated self-protective control loop. Under nominal conditions, the PA provides 17.8 dBm at 1.4 GHz into 50 Ω from a 1.2 V supply with 67% efficiency. The proposed self-protective PA can reduce its peak switch voltage below the technology-and switch design-related limit for any load with a VSWR up to 19:1, while not considerably impacting output power and efficiency, which see a maximum degradation of 1.6 dB and 6%, respectively. Furthermore, a class-E PA designed to safely handle 2.5× the nominal average switch current can reliably operate for VSWRs up to 19:1 when protected with our technique.