Local application of alendronate controls bone formation and β‐tricalcium phosphate resorption induced by recombinant human bone morphogenetic protein‐2

Kitasato, Seiichiro; Tanaka, Takaaki; Chazono, Masaaki; Komaki, Hirokazu; Kakuta, Atsuhito; Inagaki, Naoya; Akiyama, Shoshi; Marumo, Keishi

doi:10.1002/jbm.a.36833

Cited by 13 publications

(11 citation statements)

References 66 publications

(121 reference statements)

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“…Several researchers have developed scaffolds able to reproduce the physical and mechanical nature of autologous tissue and to promote osteoconduction in bone regeneration. Different materials have been already proposed in scaffolds [40]. The principal goal is to reduce cost and hospitalization time in patients that require bone regeneration treatments [41].…”

Section: Bone Regenerationmentioning

confidence: 99%

Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration

Diomede

Marconi

Fonticoli

et al. 2020

IJMS

294

177

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Bone tissue renewal can be outlined as a complicated mechanism centered on the interaction between osteogenic and angiogenic events capable of leading to bone formation and tissue renovation. The achievement or debacle of bone regeneration is focused on the primary role of vascularization occurrence; in particular, the turning point is the opportunity to vascularize the bulk scaffolds, in order to deliver enough nutrients, growth factors, minerals and oxygen for tissue restoration. The optimal scaffolds should ensure the development of vascular networks to warrant a positive suitable microenvironment for tissue engineering and renewal. Vascular Endothelial Growth Factor (VEGF), a main player in angiogenesis, is capable of provoking the migration and proliferation of endothelial cells and indirectly stimulating osteogenesis, through the regulation of the osteogenic growth factors released and through paracrine signaling. For this reason, we concentrated our attention on two principal groups involved in the renewal of bone tissue defects: the cells and the scaffold that should guarantee an effective vascularization process. The application of Mesenchymal Stem Cells (MSCs), an excellent cell source for tissue restoration, evidences a crucial role in tissue engineering and bone development strategies. This review aims to provide an overview of the intimate connection between blood vessels and bone formation that appear during bone regeneration when MSCs, their secretome—Extracellular Vesicles (EVs) and microRNAs (miRNAs) —and bone substitutes are used in combination.

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Section: Bone Regenerationmentioning

confidence: 99%

Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration

Diomede

Marconi

Fonticoli

et al. 2020

IJMS

294

177

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“…Delivering distinct GFs simultaneously, overall, enhances the innate bone-healing process [ 43 ]. Local alendronate administration to control β-tricalcium phosphate (β-TCP) resorption and the induction of bone formation by rhBMP-2 were attempted [ 44 ]. However, the administration of rhBMP-2 promoted a burst release and reduced osteoclastic resorption of β-TCP induced by rhBMP-2, resulting in decreased bone formation.…”

Section: Introductionmentioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

137

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Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

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“…β-TCP is gradually degraded during bone remodeling and is finally replaced by mature new bone. We have previously shown that the main resorption process of β-TCP is via osteoclasts [28][29][30][31][32][33][34], and the macropore and micropore structures within β-TCP affect not only material resorption but also bone formation [35][36][37]. We found that a combination of β-TCP with a superior microstructure and local BMP-2 administration accelerates bone reconstruction.…”

Section: Introductionmentioning

confidence: 99%

A New Technique to Repair Large Bone Defects

Tanaka¹,

Komaki²,

Inagaki³

et al. 2022

Preprint

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It is very difficult to repair large bone defects, especially when they have a complex shape. We have developed a new technique to make a desired copy of rabbit bones. A rabbit distal femur was scanned by computed tomography (CT), and a rectangular-shaped beta-tricalcium phosphate (β-TCP) block with 75% porosity was automatically machined using milling tools into a half-scale copy of the distal femur based on the CT data. The β-TCP block was seeded with bone morphogenetic protein-2 and bone marrow cells obtained from the femur and implanted on the periosteum of the femur. At 10 weeks after implantation, most of the β-TCP block had been replaced by bone and a complete copy of the distal femur was reconstructed. Our findings indicate that this technique will be useful in the clinical setting. We also report the representative clinical results of treatment with β-TCP graft in patients with bone defects since 1989.

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Local application of alendronate controls bone formation and β‐tricalcium phosphate resorption induced by recombinant human bone morphogenetic protein‐2

Cited by 13 publications

References 66 publications

Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration

Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration

Advances in Growth Factor Delivery for Bone Tissue Engineering

A New Technique to Repair Large Bone Defects

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