Local immunity status in patients with miscarriages and herpetic infection

Мамедалиева, Н.М.; Kurmanova, Almagul; Мошкалова, Г.Н.; Kim, V

doi:10.1080/09513590.2016.1232772

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Pregnancy loss in the early stages (up to 12 weeks) is manifested by activation of cytotoxic natural killers with CD16 þ phenotype and express suppression of the endometrial type level of CD56 þ cells, and in late stages (13-22 weeks of pregnancy) manifests a cellular deficiency, accompanied by a decrease in all cytotoxic lymphocytes -CD8þ, and natural CD56 þ and CD16 þ killers [6]. Analysis of endometrial cytotoxic lymphocytes levels depending on the form of pregnancy loss -spontaneous miscarriage and undeveloped pregnancy, with antenatal fetal death with its long delay in the uterine cavity.…”

Section: Research Findingsmentioning

confidence: 99%

Clinical and immunological parallels in pregnancy loss

Mamedaliyeva

Kurmanova

Локшин³

et al. 2017

Gynecological Endocrinology

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Peculiar characteristics of cytotoxic endometrial cells' response depending on the clinical aspects (frequency, gestational age, form of miscarriage, hysteroscopic pattern) have been studied. Patients with pregnancy loss in their past medical history demonstrate a decreased level of CD8 þ lymphocytes, and the decrease is exacerbated as the incidence of miscarriages increases and in the presence of endometrial hypoplasia. The content of CD16 þ lymphocytes increases in comparison with the control group, however, there is a reducing trend of this phenotype of killers as the incidence of miscarriages increases and in the presence of endometrial hypoplasia. Reduction of CD56 þ lymphocytes progresses with repeated pregnancy loss and endometrial hyperplasia. ARTICLE HISTORY

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Section: Research Findingsmentioning

confidence: 99%

Clinical and immunological parallels in pregnancy loss

Mamedaliyeva

Kurmanova

Локшин³

et al. 2017

Gynecological Endocrinology

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“…A study of the endometrium of women with herpetic infection has shown that early miscarriages (under 12 weeks) occurs as activation of cytotoxic natural killer (NK) cells with CD16 + phenotype and a strong suppression level of CD56 + cells endometrial type, and late miscarriages (13-22 weeks of gestation) occurs as cell deficit, followed by reduction of all CD8 + cytotoxic lymphocytes, and of CD56 + and CD16 + NK cells (30,31).…”

Section: Discussionmentioning

confidence: 99%

Viruses and genetics in pregnancy and birth

Vida,

Vulić,

Radman

et al. 2023

Biology

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In this study we presented several patients with genital infections during pregnancy, perinatal infection, de novo genetics syndromes, sterility problems and spontaneous abortions with HSV1, HSV2, CMV, Adeno, Parvo B19, RSV, EBV and Coxsackie virus. Spontaneous abortion were provoked (or at least associated) with viral infection. For some we had expected such pregnancy outcomes, and for some we observed chromosome breaks that by repetitive screening, after cessation of acute viral infection, could no longer been seen. Nonspecific chromosomal aberrations were associated with HSV type 2, herpes zoster and Ebstein Barr virus infection.

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“…Критерием тонкого эндометрия принято считать толщину эндометрия менее 7 мм и отсутствие трехслойной структуры в период «окна имплантации». Патофизиологические особенности тонкого эндометрия состоят в недостаточном росте железистого эпителия, обеднении сосудов и нарушении экспрессии ряда регуляторных цитокинов, ростовых факторов, натуральных киллеров, лимфоцитов, что в свою очередь, снижает имплантационную способность эмбрионов [3].…”

Section: ключевые слова: синдром тонкого эндометрия невынашивание беременности эндометрий цитотоксические лимфоциты эндометрия интерферонunclassified

“…Курманова 1,2 , Г.Ж. Анартаева 3 1. Научный центр акушерства, гинекологии и перинатологии, 2. Казахский Национальный университет им.…”

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Interferon Status of Endometry in Patients With Miscarriage and “Thin Endometry” Syndrome

Мамедалиева

Kurmanova

Anartaeva

et al. 2020

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The article presents the results of examination of 21 patients with miscarriage and “thin endometry” syndrome compared with 20 patients without reproductive losses and the presence of normal endometrial thickness. Interferon gamma intracellular production by cytotoxic endometrial lymphocytes was investigated by flow cytofluorometry. Based on the study, it was found that in patients with miscarriage and “thin endometry” syndrome, the interferon gamma intracellular production by cytotoxic CD8+ lymphocytes was sharply suppressed by almost 36 times, by CD56+ lymphocytes - by 13 times, by CD16+ lymphocytes - by 4.5 times.

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Local immunity status in patients with miscarriages and herpetic infection

Cited by 5 publications

References 6 publications

Clinical and immunological parallels in pregnancy loss

Clinical and immunological parallels in pregnancy loss

Viruses and genetics in pregnancy and birth

Interferon Status of Endometry in Patients With Miscarriage and “Thin Endometry” Syndrome

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