Localization by immunofluorescence of a gastrin-like substance in the brain of the rainbow trout, Salmo gairdneri

Notenboom, C. D.; Garaud, Jean-Claude; Doerr-Schott, J; Terlou, M.

doi:10.1007/bf00249209

Cited by 23 publications

(1 citation statement)

References 31 publications

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“…In the codfish Gadus morhua, a caerulein-like peptide was reported as the main component of the population of gut endocrine cells (LARSSON and REHFELD, 1977), while in elasmobranchs and cyclostomes, bioassay and immunohistochemical studies revealed the presence of gastrin/CCK-like peptides and caerulein-immunopositive cells in the intestinal epithelium ( VAN NOORDEN and PEARSE, 1974;HANSEN, 1975). Peptides of the gastrin/ CCK family are not localized solely in the endocrine cells of fish, but have also been reported in neurons in both the peripheral and central nervous systems (NOTENBOOM et al, 1981;HOLMGREN and NILSSON, 1983a, b;BJENNING and HOLMGREN, 1988). Gastrin, caerulein and related peptides influence gastric acid secretion in some non-mammalian species (JONSSON, 1989), but the function of caerulein in fish is not known.…”

Section: Discussionmentioning

confidence: 99%

Ectopic expression of bioactive peptides and serotonin in the sacciform gland cells of teleost skin.

Fasulo

Tagliafierro

Contini

et al. 1993

Archives of Histology and Cytology

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Section: Discussionmentioning

confidence: 99%

Ectopic expression of bioactive peptides and serotonin in the sacciform gland cells of teleost skin.

Fasulo

Tagliafierro

Contini

et al. 1993

Archives of Histology and Cytology

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Distribution of cholecystokinin‐like‐immunoreactive neurons in the guinea pig forebrain

Ciofi

Tramu

1990

J of Comparative Neurology

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The distribution of cholecystokinin (CCK)-immunoreactive nerve fibers and cell bodies was studied in the forebrain of control and colchicine-treated guinea pigs by using an antiserum directed against the carboxyterminus of CCK octapeptide (CCK-8) in the indirect immunoperoxidase technique. Virtually all forebrain areas examined contained immunoreactive nerve fibers. A dense innervation was visualized in; neocortical layers II-III, piriform cortex, the medial amygdala, the medial preoptic area, a circumventricular organ-like structure located at the top of the third ventricle in the preoptic area, the subfornical organ, the posterior bed nucleus of the stria terminalis, the posterior globus pallidus (containing labeled woolly fiber-like profiles), the ventromedial hypothalamus, the median eminence, and the premammillary nucleus. A moderately dense innervation was visualized elsewhere excepted in the septum and thalamus where labeled axons were comparatively few. Immunoreactive perikarya were abundant in: neocortex (especially layers II-III), piriform cortex, amygdala, the median preoptic nucleus, the bed nucleus of the stria terminalis, the hypothalamic paraventricular (parvicellular part), arcuate, and dorsomedial (pars compacta) nuclei, the dorsal and perifornical hypothalamic areas, and throughout the thalamus. Areas also containing a moderate number of labeled cell bodies were the medial preoptic area, the globus pallidus, the caudate-putamen, and the periventromedial area in the hypothalamus. Immunostained perikarya were absent or only occasionally observed in the septum, the suprachiasmatic nucleus, the magnocellular hypothalamoneurohypophyseal nuclei, and the ventral mesencephalon. In the adenohypophysis, corticomelanotrophs were labeled in both males and females, and thyrotrophs were labeled in females only. This distribution pattern of CCK-8 immunoreactivity is compared to those previously recorded in other mammals. This shows that very few features are peculiar to the the guinea pig. It is discussed whether some interspecific differences in immunostaining are real rather than methodological.

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Comparative distribution of neuropeptide‐immunoreactive systems in the brain of the green molly, Poecilia latipinna

Batten¹,

Cambre²,

Moons³

et al. 1990

J of Comparative Neurology

277

184

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The comparative distribution of peptidergic neural systems in the brain of the euryhaline, viviparous teleost Poecilia latipinna (green molly) was examined by immunohistochemistry. Topographically distinct, but often overlapping, systems of neurons and fibres displaying immunoreactivity (ir) related to a range of neuropeptides were found in most brain areas. Neurosecretory and hypophysiotrophic hormones were localized to specific groups of neurons mostly within the preoptic and tuberal hypothalamus, giving fibre projections to the neurohypophysis, ventral telencephalon, thalamus, and brain stem. Separate vasotocin (AVT)-ir and isotocin (IST)-ir cells were located in the nucleus preopticus (nPO), but many AVT-ir nPO neurons also displayed growth hormone-releasing factor (GRF)-like-ir, and in some animals corticotrophin-releasing factor (CRF)-like-ir. The main group of CRF-ir neurons was located in the nucleus recessus anterioris, where coexistence with galanin (GAL) was observed in some cells. Enkephalin (ENK)-like-ir was occasionally present in a few IST-ir cells of the nPO and was also found in small neurons in the posterior tuberal hypothalamus and in a cluster of large cells in the dorsal midbrain tegmentum. Thyrotrophin-releasing hormone (TRH)-ir cells were found near the rostromedial tip of the nucleus recessus lateralis. Gonadotrophin-releasing hormone (GnRH)-ir cells were present in the nucleus olfactoretinalis, ventral telencephalon, preoptic area, and dorsal midbrain tegmentum. Molluscan cardioexcitatory peptide (FMRF-amide)-ir was colocalized with GnRH-ir in the ganglion cells and central projections of the nervus terminalis. Melanin-concentrating hormone (MCH)-ir neurons were restricted to the tuberal hypothalamus, mostly within the nucleus lateralis tuberis pars lateralis, and somatostatin (SRIF)-ir neurons were numerous throughout the periventricular areas of the diencephalon. A further group of SRIF-ir neurons extending from the ventral telencephalon into the dorsal telencephalon pars centralis also contained neuropeptide Y (NPY)-, peptide YY (PYY)-, and NPY flanking peptide (PSW)-like-ir. These immunoreactivities were, however, also observed in non-SRIF-ir cells and fibres, particularly in the mesencephalon. Calcitonin gene-related peptide (CGRP)-like-ir had a characteristic distribution in cells grouped in the isthmal region and fibre tracts running forward into the hypothalamus, most strikingly into the inferior lobes. Antisera to cholecystokinin (CCK) and neurokinin A (NK) or substance P (SP) stained very extensive, separate systems throughout the brain, with cells most consistently seen in the ventral telencephalon and periventricular hypothalamus. Broadly similar, but much more restricted, distributions of cells and fibres were seen with antisera to neurotensin (NT) and vasoactive intestinal peptide (VIP).(ABSTRACT TRUNCATED AT 400 WORDS)

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Localization by immunofluorescence of a gastrin-like substance in the brain of the rainbow trout, Salmo gairdneri

Cited by 23 publications

References 31 publications

Ectopic expression of bioactive peptides and serotonin in the sacciform gland cells of teleost skin.

Ectopic expression of bioactive peptides and serotonin in the sacciform gland cells of teleost skin.

Distribution of cholecystokinin‐like‐immunoreactive neurons in the guinea pig forebrain

Comparative distribution of neuropeptide‐immunoreactive systems in the brain of the green molly, Poecilia latipinna

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