Localization of the porcine growth hormone gene to chromosome 12pl.2 p1–5

Yerle, Martine M.; Lahbib-Mansais, Y.; Pd, Thomsen; Gellin, Joël

doi:10.1111/j.1365-2052.1993.tb00254.x

Cited by 25 publications

(3 citation statements)

References 38 publications

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“…Although the current pig gene map features some disagreements, the localization of GH has been confirmed by several studies (Thomsen et al 1990;Chowdhary et al 1992;Echard et al 1992). The exact localization was recently corrected by Yerle et al (1993), who provide convincing evidence for a localization on pig chromosome 12p. TP53 maps on pig chromosome 12q (Fig.…”

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confidence: 79%

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Localization of the tumour protein, TP53, on porcine chromosome 12q12‐q14

1993

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Summary A human cDNA probe of the tumour protein p53 (TP53) was used to localize the homologous porcine gene by in situ hybridization. The gene was mapped to chromosome 12q12‐q14. Together with already known mapping data, these results confirm the localization of an evolutionary conserved linkage group on porcine chromosome 12 which is localized in man on chromosome 17, in cattle on chromosome 19, and in mice on chromosome 11.

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confidence: 79%

“…A prominent evolutionary conserved linkage group is that on human chromosome 17, which in the mouse is found on chromosome 11, and extends from 17pter to 17qter. Recent reports have mapped the porcine growth hormone gene to chromosome 12p (Thomsen et al 1990;Chowdhary et al 1992;Yerle et al 1993). This gene maps in man to 17q23 (Harper et al 1982).…”

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confidence: 99%

Localization of the tumour protein, TP53, on porcine chromosome 12q12‐q14

1993

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“…Porcine growth hormone gene was sequenced by Vize et al (1984). It contains four introns and five exons, and the gene was assigned to porcine chromosome 12p1.2-p1.5 (Yerle et al, 1993). The effects of GH gene variations on performance traits have been described for cattle (Rocha, et al, 1992;Schlee et al, 1994) and mice (Winkelman and Hodgetts, 1992).…”

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confidence: 99%

Polymorphism of Growth Hormone Gene in 12 Pig Breeds and Its Relationship with Pig Growth and Carcass Traits

Wang¹,

Huang²,

Gao³

et al. 2003

Asian Australas. J. Anim. Sci

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The polymorphism of the growth hormone gene in 12 pig breeds (total n=475) was detected by PCR-ApaⅠ-RFLP, and allele A (449 bp, 101 bp and 55 bp) or allele B (316 bp, 133 bp, 101 bp and 55 bp) were observed. In these pig breeds, we found that European pig breeds had high frequencies of allele B, while Chinese native pig breeds had high frequencies of allele A. In addition, the role of porcine GH was investigated in 117 Nanchang White pigs and 361 Large Yorkshire pigs. Eight traits about growth and carcass were recorded for analyzing associations between GH gene polymorphism and performance quantitative traits. In the Nanchang White pigs, no significant difference was observed between different genotypes and different growth and carcass traits. In Large Yorkshire pigs, those with BB genotype had more lean percentage than pigs with AA genotype (p<0.05). Based on these results, we conclude that the GH locus should be further investigated in commercial breeds to determine its suitability for use in marker-assisted selection programmes.

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Genetic variation at the growth hormone locus in a wild pig intercross; test of association to phenotypic traits and linkage to the blood group D locus

Ellegren

et al. 1995

Theoret. Appl. Genetics

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A polymorphism in the TATA-box of the porcine growth hormone (GH) gene was analysed in a wild pig/Large White intercross, in which 129 markers had been scored previously. Linkage analyses demonstrated that the GH locus belonged to a linkage group on chromosome 12 together with a previously unassigned marker, the erythrocyte antigen D (EAD) locus. The linear order of this linkage group is EAD-GH-S0096-S0090-S0106-arachidonate 12-lipoxygenase (ALOX12)-inhibin beta A (INHBA). The length of the linkage group was estimated at 93 cM (sex average). The effects of the GH genotype on growth and fat deposition traits were investigated using phenotypic data from the 191 F2 animals. No significant effect of GH was detected, and we therefore conclude that this locus does not play a major role in defining the genetic differences between the wild and Large White pigs for these traits.

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Localization of the porcine growth hormone gene to chromosome 12pl.2 p1–5

Cited by 25 publications

References 38 publications

Localization of the tumour protein, TP53, on porcine chromosome 12q12‐q14

Localization of the tumour protein, TP53, on porcine chromosome 12q12‐q14

Polymorphism of Growth Hormone Gene in 12 Pig Breeds and Its Relationship with Pig Growth and Carcass Traits

Genetic variation at the growth hormone locus in a wild pig intercross; test of association to phenotypic traits and linkage to the blood group D locus

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