Localization of vasoactive intestinal peptide immunoreactivity in human foetus and newborn infant spinal cord

Charnay, Yves; Ja, Chayvialle; Si, Said; Pm, Dubois

doi:10.1016/0306-4522(85)90173-3

Cited by 25 publications

(8 citation statements)

References 37 publications

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“…We thought that NOS positive megaloneurite was important to verity the existent megaloneurite in aged sacral spinal cord. VIP is important neuropeptide to regulate pelvic organs [13,[44][45][46]. However, different to NO-ergic neuronal positivity, no cell body was detected in our experiments.…”

Section: Discussioncontrasting

confidence: 70%

“…The verification of megaloneurites by VIP examination should be considered in sacral spinal cord of aged human, because distribution of VIP is significantly higher in dorsal than in ventral gray matter in human [11]. Compared with several other neuropeptides, the concentration of VIP shows much higher in the lumbosacral spinal cord in human [12,13]. Anand suggested: "some of VIP-like immunoactivity is the primary afferent fiber" in his study.…”

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confidence: 99%

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Megaloneurite, a giant neurite of vasoactive intestinal peptide and nitric oxide synthase in the aged dog and identification by human sacral spinal cord

Hou

Jia

et al. 2019

Preprint

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Megaloneurite of NADPH diaphorase (NADPH-d) positivity is a new kind of aging-related neurodegeneration and also co-localized with vasoactive intestinal peptide (VIP) in the sacral spinal cord of aged dog and monkey. However, no immunocytochemistry of VIP was exclusively tested in the aged dog and no evidence has been reported in the aged human spinal cord. Aged dogs were used to examine the distribution of VIP immunopositivity in the sacral spinal cord. Immunocytochemistry of VIP and alpha-synuclein were also examined in the aged human spinal cord. The VIP immunopositivity in aged dog was reconfirmed our previous finding illustrated by immunofluorescent study. Megalogneurite was also identified by nitric oxide synthase (NOS) immunoreaction in aged dog. The VIP positive megaloneurites both in age dog and human were detected in dorsal root entry zoon, Lissauer's tract, dorsal commissural nucleus and anterior commissural gray as well as in the lateral funiculus of the sacral spinal cord exclusive of other segments of spinal cord. Alpha-synuclein positivity was present mini-aggregation and Lewy body in the sacral spinal cord of aged human, that also occurred in the lumber, thoracic and cervical spinal cord. It was firstly tested that VIP megaloneurites occurred in the aged human sacral spinal cord, especially in the white matter. Megaloneurites identified by NADPH-d-VIP-NOS immunoreaction could implicate for the dysfunction of pelvic organs in the aged human being. Vasoactive intestinal peptide (VIP) acts on neuronal cells to support physiological condition and protect neurons survival in pathological condition[1-3]. Different from other neuropeptides, the distribution of VIP is restricted to the sacral cord[4]. Or it is majorly distributed in the sacral spinal cord and a few of VIP positivity is detected in the other segment of the spinal cord in cat[5].VIP neurons are small-size neurons and central original source for peripheral innervation[6]. VIP-ergic afferent neurons projected to the pelvic organs are bigger proportion that the other segments, while the lower lumbosacral segments of the neuropeptide innervation was also more priority to the upper lumber segment[7]. VIP fibers are majorly found in the Lissauer's tract (LT), superficial lamina,

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Section: Discussioncontrasting

confidence: 70%

mentioning

confidence: 99%

Megaloneurite, a giant neurite of vasoactive intestinal peptide and nitric oxide synthase in the aged dog and identification by human sacral spinal cord

Hou

Jia

et al. 2019

Preprint

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“…Our conclusions regarding the termination of C-fibers apply to the sacral spinal cord of the cat but might be extended to other species at an equivalent level of the spinal cord. For example, the morphology of the sensory innervation of the pelvic organs in the lumbosacral spinal cord in humans, baboons, monkeys, guinea pigs, and rats is similar in many respects to that in the cat (Anand et al, 1983;Kawatani et al, 1983a;Nadelhaft, 1983;Charnay et al, 1984;Gibson et al, 1984;de Groat et al, 1986;LaMotte and deLanerolle, 1986;Brady et al, 1988;Chung et al, 1989). It would be reasonable to expect that the pelvic reflexes in these species might be dependent upon similar sensory mechanisms.…”

Section: Vip In Unmyelinated Sensory Axonsmentioning

confidence: 98%

Vasoactive intestinal polypeptide in sacral primary sensory pathways in the cat

1999

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Unmyelinated sensory axons in the sacral spinal cord may play a role in bladder reflexes under certain pathological conditions. Previous data suggested vasoactive intestinal polypeptide (VIP) might be contained exclusively in sensory C‐fibers, some of which innervate the bladder. This study was undertaken to describe the morphology of these VIP fibers in the sacral cord of the cat. VIP immunoreactivity was confined to unmyelinated axons observed at several levels of the sensory pathway including the dorsal root ganglia, dorsal roots, Lissauer's tract, and the lateral collateral pathway. A combination of light and electron microscopic observations showed VIP‐immunoreactive fibers with labeled varicosities and synaptic terminals in laminae I, IIo, V, VII, and X. VIP‐immunolabeled varicosities had a mean diameter of 1.6 μm (range = 0.11–7.4 μm, S.D. = 1.01, n = 311) with a small percentage (8%) being relatively large (3–7.4 μm). VIP varicosities contained a mixture of small clear vesicles (CLV) and large dense core vesicles (LDV). Although most varicosities contained a moderate number of LDVs (14.86 LDVs/μm2), some varicosities contained a large number of LDVs, whereas others contained very few. Varicosities that possessed synaptic specializations were classed as terminals and were divided into three morphological classes. Two of these resembled Gray's Type I terminal, whereas a third was similar to the Gray's Type II terminal. There was no consistent relationship between vesicle content of the terminal and the type of synaptic contact it possessed. This study shows that in the sacral spinal cord of the cat, VIP terminals originate only from C‐fibers, terminate primarily in laminae I and V, and exhibit a variety of morphologies consistent with heterogeneous origins and functions of the lower urinary tract. J. Comp. Neurol. 407:381–394, 1999. © 1999 Wiley‐Liss, Inc.

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“…The administration of a VIP antagonist during a critical period of neurogenesis (E9-11) resulted in microcephaly, with a disproportionately greater inhibition of brain growth compared to the rest of the body, while the administration of the same antagonist later in gestation had no detectable effect on embryonic growth [33]. In humans, VIP expression has also been detected in fetus and new born infant spinal cord [35]. In humans, VIP expression has also been detected in fetus and new born infant spinal cord [35].…”

Section: Role Of Vip In Neurodevelopmental Disordersmentioning

confidence: 99%

VIP in Neurological Diseases: More Than A Neuropeptide

Morell

Souza-Moreira²,

González‐Rey³

2012

EMIDDT

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A hallmark in most neurological disorders is a massive neuronal cell death, in which uncontrolled immune response is usually involved, leading to neurodegeneration. The vasoactive intestinal peptide (VIP) is a pleiotropic peptide that combines neuroprotective and immunomodulatory actions. Alterations on VIP/VIP receptors in patients with neurodenegerative diseases, together with its involvement in the development of embryonic nervous tissue, and findings found in VIP-deficient mutant mice, have showed the relevance of this endogenous peptide in normal physiology and in pathologic states of the central nervous system (CNS). In this review, we will summarize the role of VIP in normal CNS and in neurological disorders. The studies carried out with this peptide have demonstrated its therapeutic effect and render it as an attractive candidate to be considered in several neurological disorders linked to neuroinflammation or abnormal neural development.

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Localization of vasoactive intestinal peptide immunoreactivity in human foetus and newborn infant spinal cord

Cited by 25 publications

References 37 publications

Megaloneurite, a giant neurite of vasoactive intestinal peptide and nitric oxide synthase in the aged dog and identification by human sacral spinal cord

Megaloneurite, a giant neurite of vasoactive intestinal peptide and nitric oxide synthase in the aged dog and identification by human sacral spinal cord

Vasoactive intestinal polypeptide in sacral primary sensory pathways in the cat

VIP in Neurological Diseases: More Than A Neuropeptide

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