Localized Aggressive Periodontitis in a Patient With Type 1 Diabetes Mellitus: A Case Report

Emingil, Gülnur; Darcan, Şükran; Keskınoğlu, Ahmet; Kütükçüler, Necil; Atilla, Gül

doi:10.1902/jop.2000.72.9.1265

Cited by 13 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 The role of DM in various periodontal diseases has been extensively investigated, with 1 study indicating an impact of periodontal inflammation on diabetic balance. 22 It is reported that DM aggravates both severity and progression of periodontal disease, [44][45][46][47][48] and especially poor metabolic control of DM has often been associated with the severity of periodontitis. 26,33,44,49 The structural changes characterizing diabetic microangiopathy, which may be referred to as abnormal growth and impaired regeneration, strongly suggest a role for a number of aberrantly expressed growth factors, possibly acting in combination, in the development of these complications.…”

Section: Discussionmentioning

confidence: 99%

“…22 It is reported that DM aggravates both severity and progression of periodontal disease, [44][45][46][47][48] and especially poor metabolic control of DM has often been associated with the severity of periodontitis. 26,33,44,49 The structural changes characterizing diabetic microangiopathy, which may be referred to as abnormal growth and impaired regeneration, strongly suggest a role for a number of aberrantly expressed growth factors, possibly acting in combination, in the development of these complications. This initial speculation has been supported by the detection of increased concentrations of several growth factors in the target tissues of diabetic long-term complications and by enhanced expression of these growth factors consequent to the activation of the biochemical pathway linking hyperglycemia to microvascular changes: the Booth et al 17 have suggested that VEGF was generally upregulated even in relatively healthy sites, probably either reflecting subclinical levels of inflammation/ healing after the microbial assault, or revealing the presence of VEGF as a component of physiological angiogenesis in the gingival/periodontal environment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Vascular Endothelial Growth Factor in Human Periodontal Tissues: Comparison of Healthy and Diabetic Patients

Ünlü

Güneri²,

Hekımgıl³

et al. 2003

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expression of Vascular Endothelial Growth Factor in Human Periodontal Tissues: Comparison of Healthy and Diabetic Patients

Ünlü

Güneri²,

Hekımgıl³

et al. 2003

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…82 Hyperactive or dysregulated neutrophils may lead to collateral tissue damage by releasing inflammatory and toxic substances or tissue-degrading enzymes. [83][84][85][86] Diabetes in vivo and high glucose in vitro stimulate greater production of chemokines that induce neutrophil recruitment in response to a bacterial challenge. 63,[87][88][89] High glucose stimulates neutrophil priming by elevating protein kinase C activity.…”

Section: Iab E Te S and The Hos T Re S P On S Ementioning

confidence: 99%

The impact of diabetes on periodontal diseases

Graves

Ding

Yang

2019

Periodontology 2000

239

172

View full text Add to dashboard Cite

The susceptibility and severity of periodontal diseases is made more severe by diabetes, with the impact on the disease process inversely proportional to the level of glycemic control. Although type 1 diabetes mellitus and type 2 diabetes mellitus have different etiologies, and their impact on bone is not identical, they share many of the same complications. Studies in animals and humans agree that both forms of diabetes increase inflammatory events in periodontal tissue, impair new bone formation, and increase expression of RANKL in response to bacterial challenge. High levels of glucose, reactive oxygen species, and advanced glycation end‐products are found in the periodontium of diabetic individuals and lead to increased activation of nuclear factor‐kappa B and expression of inflammatory cytokines such as tumor necrosis factor and interleukin‐1. Studies in animals, moreover, suggest that there are multiple cell types in periodontal tissues that are affected by diabetes, including leukocytes, vascular cells, mesenchymal stem cells, periodontal ligament fibroblasts, osteoblasts, and osteocytes. The etiology of periodontal disease involves the host response to bacterial challenge that is affected by diabetes, which increases the expression of RANKL and reduces coupled bone formation. In addition, the inflammatory response also modifies the oral microbiota to render it more pathogenic, as demonstrated by increased inflammation and bone loss in animals where bacteria are transferred from diabetic donors to germ‐free hosts compared with transfer from normoglycemic donors. This approach has the advantage of not relying upon limited knowledge of the specific bacterial taxa to determine pathogenicity, and examines the overall impact of the microbiota rather than the presumed pathogenicity of a few bacterial groups. Thus, animal studies have provided new insights into pathogenic mechanisms that identify cause‐and‐effect relationships that are difficult to perform in human studies.

show abstract

“…that diabetics have a higher risk of the development and progression of gingivitis or periodontitis [16,39,43,45]. Exactly when hyperglycemia exerts an effect on periodontal tissue has been frequently examined, with controversial results.…”

Section: Secondary Diseases and Complicationsmentioning

confidence: 99%

Influence of Diabetes Mellitus on the Development and Treatment of Malocclusions – A Case Report with Literature Review

2009

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic disorder characterized by disturbed glucose regulation, manifesting primarily as chronic hyperglycemia. Today about 6% of the world's population suffers from diabetes mellitus. This metabolic disorder is known to be associated with a large number of concomitant and secondary diseases of the cardiovascular system, as well as of the joint and supporting tissue systems. It is also a recognized fact that diabetes mellitus is closely associated with diverse problems in the oral, facial and jaw regions. These facts suggest that patients with diabetes may respond to orthodontic treatment differently from those without diabetes in how the periodontium and surrounding visceral cranium react to therapy. Beginning with a clinical case report we proceed to present a general overview of the clinical features and pathophysiology of diabetes mellitus, followed by a critical discussion of the results of a systematic literature search for aspects of the disease relevant to orthodontics.

show abstract

Localized Aggressive Periodontitis in a Patient With Type 1 Diabetes Mellitus: A Case Report

Cited by 13 publications

References 35 publications

Expression of Vascular Endothelial Growth Factor in Human Periodontal Tissues: Comparison of Healthy and Diabetic Patients

Expression of Vascular Endothelial Growth Factor in Human Periodontal Tissues: Comparison of Healthy and Diabetic Patients

The impact of diabetes on periodontal diseases

Influence of Diabetes Mellitus on the Development and Treatment of Malocclusions – A Case Report with Literature Review

Contact Info

Product

Resources

About