Locally Recurrent Rectal Cancer

Radice, Elisabetta; Dozois, Roger R.

doi:10.1159/000050173

Cited by 32 publications

(18 citation statements)

References 36 publications

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“…Since total mesorectal excision was adopted as the standard treatment of patients with rectal carcinoma, improvements have been made in decreasing its local recurrence and prolonging survival of patients [1][2][3][4][5][6][7][8] . However, even having undergone radical resection with total mesorectal excision, about 5%-40% of patients with rectal carcinoma have local recurrence [9][10][11][12][13][14] . The survival of patients with advanced low rectal cancer www.wjgnet.com still remains poor.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

Zeyu¹,

Wu²,

Jin³

et al. 2007

WJG

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AIM:To evaluate the risk factors for lateral lymph node metastasis in patients with advanced low rectal cancer, in order to make the effective selection of patients who could benefit from lateral lymph node dissection, as well as the relationship of lateral lymph node metastasis with local recurrence and survival of patients with advanced low rectal cancer. METHOD S :A t o t a l o f 9 6 c o n s e c u t i v e p a t i e n t s who underwent curative surgery with lateral pelvic lymphadenectomy for advanced lower rectal cancer were retrospectively analyzed. The relation of lateral lymph node metastasis with clinicopathologic characteristics, local recurrence and survival of patients was identified. RESULTS:Lateral lymph node metastasis was observed in 14.6% (14/96) of patients with advanced low rectal cancer. Lateral lymph node metastasis was detected in 10 (25.0%) of 40 patients with tumor diameter ≥ 5 cm and in 4 (7.1%) of 56 patients with tumor diameter < 5 cm. The difference between the two groups was statistically significant (χ 2 = 5.973, P = 0.015). Lateral lymph node metastasis was more frequent in patients with 4/4 diameter of tumor infiltration (7 of 10 cases, 70.0%), compared with patients with 3/4, 2/4 and 1/4 diameter of tumor infiltration (3 of 25 cases, 12.0%; 3 of 45 cases, 6.7%; 1 of 16 cases, 6.3%) (χ 2 = 27.944, P = 0.0001).The lateral lymph node metastasis rate was 30.0% (9 of 30 cases), 9.1% (4 of 44 cases) and 4.5% (1 of 22 cases) for poorly, moderately and well-differentiated carcinoma, respectively. The difference between the three groups was statistically significant (χ 2 = 8.569, P = 0.014). Local recurrence was 18.8% (18 of 96 cases), 64.3% (9 of 14 cases), and 11.0% (9 of 82 cases) in patients with advanced low rectal cancer, in those with and without lateral lymph node metastasis, respectively. The difference between the two groups was statistically significant (χ 2 = 22.308, P = 0.0001).Kaplan-Meier survival analysis showed significant improvements in median survival (80.9 ± 2.1 m, 95%CI: 76.7-85.1 m vs 38 ± 6.7 m, 95% CI: 24.8-51.2 m) of patients without lateral lymph node metastasis compared with those with lateral lymph node metastasis (log-rank, P = 0.0001). CONCLUSION:Tumor diameter, infiltration and differentiation are significant risk factors for lateral lymph node metastasis. Lateral pelvic lymphadenectomy should be performed following surgery for patients with tumor diameter ≥ 5 cm. Lateral lymph node metastasis is an important predictor for local recurrence and survival in patients with advanced low rectal cancer.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

Zeyu¹,

Wu²,

Jin³

et al. 2007

WJG

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“…Local recurrence of middle and lower rectal carcinoma after curative resection has significant morbidity and mortality [4,[12][13][14][15] and its recurrence rate varies from less than 4% to greater than 50%. Since TME was adopted as the standard treatment of patients with rectal carcinoma, a significant decrease in local recurrence and a trend to improve relative survival have been reported [16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

“…However, local recurrence of rectal carcinoma occurs in about 4%-50% of patients even after radical resection of primary tumors and lymph nodes [4][5][6][7][8] . The risk factors for local recurrence of rectal carcinoma remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for local recurrence of middle and lower rectal carcinoma after curative resection

Wan²,

Zhao³

et al. 2008

WJG

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AIM:To explore the risk factors for local recurrence of middle and lower rectal carcinoma after curative resection. METHODS: Specimens of middle and lower rectal carcinoma from 56 patients who received curative resection at the Department of General Surgery of Guangdong Provincial People's Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. The relations between clinicopathologic c h a r a c t e r i s t i c s , m e s o r e c t a l m e t a s t a s i s a n d circumferential resection margin status were identified in patients with local recurrence of middle and lower rectal carcinoma. RESULTS: Local recurrence of middle and lower rectal carcinoma after curative resection occurred in 7 of the 56 patients (12.5%), and was significantly associated with family history (c

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“…The literature indicated that the local recurrence rate of rectal carcinoma after simple radical resection was 4% to 40% [1]. The survival period of patients with untreated postoperative local recurrence is generally 3.5 to 13 months [2].…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of concurrent 3DCRT and XELOX treatment for postoperative local recurrence of rectal carcinoma in elderly patients

Zhuang¹,

Xu²,

Xu³

et al. 2013

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Locally Recurrent Rectal Cancer

Cited by 32 publications

References 36 publications

Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

Risk factors for local recurrence of middle and lower rectal carcinoma after curative resection

Clinical analysis of concurrent 3DCRT and XELOX treatment for postoperative local recurrence of rectal carcinoma in elderly patients

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