Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer

Abstract

A number of long non-coding RNAs (lncRNAs) have been found to play critical roles in oncogenesis and tumor progression. We aimed to investigate whether lncRNAs could act as prognostic biomarkers for papillary thyroid cancer (PTC) that may assist us in evaluating disease status and prognosis for patients. We found 220 lncRNAs with expression alteration from the annotated 2773 lncRNAs approved by the HUGO gene nomenclature committee in The Cancer Genome Atlas (TCGA) dataset, of which FAM41C, CTBP1-AS2, LINC00271, HAR1A, LINC00310 and HAS2-AS1 were associated with recurrence. After adjusting classical clinicopathogical factors and BRAFV600E mutation, LINC00271 was found to be an independent risk factor for extrathyroidal extension, lymph node metastasis, advanced tumor stage III/IV and recurrence in multivariate analyses. Additionally, LINC00271 expression was significantly downregulated in PTCs versus adjacent normal tissues (P < 0.001). The Gene Set Enrichment Analysis (GSEA) revealed that genes associated with cell adhesion molecules, cell cycle, P53 signaling pathway and JAK/STAT signaling pathway were remarkably enriched in lower-LINC00271 versus higher-LINC00271 tumors. In conclusion, LINC00271 was identified as a possible suppressor gene in PTC in our study, and it may serve as a potential predictor of poor prognoses in PTC.

Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway

“…For instance, Ma et al revealed that genes associated with the p53 signaling pathway and the JAK/STAT signaling pathway were remarkable enriched in papillary thyroid tumors with LINC00271 down-regulation through GSEA. 20 GSEA also clearly showed that OxPhos and MRP genes sets were distinctively downregulated in thyroid cancer tissues. 21 Through bioinformatics analysis, Lee et al identified that the mitochondrial calcium transporter LETM1 was associated cellular growth signals such as the insulin signaling pathway, and it was up-regulated in aggressive thyroid cancer.…”

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

“…Due to the crucial role of lncRNAs regulation at the transcription level, lncRNAs are involved in many important biological functions, such as differentiation and proliferation. Furthermore, lncRNAs show aberrant expression patterns in various cancer types, and dysregulation of lncRNAs may influence the neoplastic progression and prognosis of human malignancies [ 27 – 29 ].…”

Dissecting the role of hyaluronan synthases in the tumor microenvironment

“…Recently, the coordinated expression of HAS2-AS1 and HAS2 was also described in oral squamous cell carcinoma, where HAS2-AS1-mediated hypoxia-induced cell invasiveness and EMT by stabilizing HAS2 [24]. Similarly, HAS2-AS1 is involved in TFG-b-induced EMT in breast cancer cells [104], and in papillary thyroid cancer recurrence [105]. Furthermore, HAS2-AS1 is present not only in the nucleus [99] but also in the cytosol [104].…”