Long-Lasting Effect of Transcranial Direct Current Stimulation in the Reversal of Hyperalgesia and Cytokine Alterations Induced by the Neuropathic Pain Model

Cioato, Stefânia Giotti; Medeiros, Liciane Fernandes; Filho, Paulo Ricardo Marques; Vercelino, Rafael; Souza, Andressa de; Scarabelot, Vanessa Leal; Oliveira, Carla de; Adachi, Lauren Naomi Spezia; Fregni, Felipe; Caumo, Wolnei; Torres, Iraci Lucena da Silva

doi:10.1016/j.brs.2015.12.001

Cited by 69 publications

(96 citation statements)

References 79 publications

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“…In our study, the anode stimulation electrode was mounted contralateral or ipsilateral to the injured paw to measure the antinociceptive effect of tDCS, and our results demonstrated that both locations of A-tDCS led to significant decreases in pain. Our study supplements previous experiments in which the location of the electrode was not taken into consideration (Cioato et al, 2016; Filho et al, 2016). A possible mechanism of these results is supra-spinal antinociceptive activities via multiple parallel pathways (Pertovaara and Wei, 2003).…”

Section: Discussionsupporting

confidence: 89%

“…Numerous clinical studies have concluded that A-tDCS is an effective method for pain modulations, which is helpful at reducing both fibromyalgia and spinal cord injury related-pain (Fregni et al, 2006; Roizenblatt et al, 2007; Soler et al, 2010). There are also studies showing effects of A-tDCS in inflammatory and neuropathic pain in animals (Laste et al, 2012; Spezia Adachi et al, 2012; Cioato et al, 2016; Filho et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

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Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Han

Gao

Zhao

et al. 2017

Front. Behav. Neurosci.

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Background: Transcranial direct current stimulation (tDCS) is widely used to treat human nerve disorders and neuropathic pain by modulating the excitability of cortex. The effectiveness of tDCS is influenced by its stimulation parameters, but there have been no systematic studies to help guide the selection of different parameters.Objective: This study aims to assess the effects of tDCS of primary motor cortex (M1) on chronic neuropathic pain in rats and to test for the optimal parameter combinations for analgesia.Methods: Using the chronic neuropathic pain models of chronic constriction injury (CCI), we measured pain thresholds before and after anodal-tDCS (A-tDCS) using different parameter conditions, including stimulation intensity, stimulation time, intervention time and electrode located (ipsilateral or contralateral M1 of the ligated paw on male/female CCI models).Results: Following the application of A-tDCS over M1, we observed that the antinociceptive effects were depended on different parameters. First, we found that repetitive A-tDCS had a longer analgesic effect than single stimulus, and both ipsilateral-tDCS (ip-tDCS) and contralateral-tDCS (con-tDCS) produce a long-lasting analgesic effect on neuropathic pain. Second, the antinociceptive effects were intensity-dependent and time-dependent, high intensities worked better than low intensities and long stimulus durations worked better than short stimulus durations. Third, timing of the intervention after injury affected the stimulation outcome, early use of tDCS was an effective method to prevent the development of pain, and more frequent intervention induced more analgesia in CCI rats, finally, similar antinociceptive effects of con- and ip-tDCS were observed in both sexes of CCI rats.Conclusion: Optimized protocols of tDCS for treating antinociceptive effects were developed. These findings should be taken into consideration when using tDCS to produce analgesic effects in clinical applications.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Han

Gao

Zhao

et al. 2017

Front. Behav. Neurosci.

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“…Previous data from our group showed that tDCS was able to revert the mechanical and thermal hyperalgesia in neuropathic pain induced by the CCI model (Cioato et al, 2014).…”

Section: Resultsmentioning

confidence: 97%

Transcranial direct current stimulation (tDCS) reverts behavioral alterations and brainstem BDNF level increase induced by neuropathic pain model: Long-lasting effect

Filho

Vercelino

Cioato

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Mechanical allodynia was assessed at P16, P30, and P60 as previously described by Cioato et al (2016). The Von Frey aesthesiometer (Insight, São Paulo, Brazil) is adapted from the classical von Frey filament test, in which pressure intensity is recorded automatically after paw removal (Vivancos et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Morphine exposure during early life alters thermal and mechanical thresholds in rats

Nunes

Medeiros

Freitas

et al. 2016

Intl J of Devlp Neuroscience

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Long-Lasting Effect of Transcranial Direct Current Stimulation in the Reversal of Hyperalgesia and Cytokine Alterations Induced by the Neuropathic Pain Model

Cited by 69 publications

References 79 publications

Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Transcranial direct current stimulation (tDCS) reverts behavioral alterations and brainstem BDNF level increase induced by neuropathic pain model: Long-lasting effect

Morphine exposure during early life alters thermal and mechanical thresholds in rats

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