Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

Abstract

Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection.

Emerging porous organic polymers for biomedical applications

“…By incorporating the N -halamine moiety, Wu et al recently reported that a porous polymeric coating on titanium surfaces can function as long-lasting and renewable antibacterial biomaterials to prevent and treat peri-implant infections. 279 Peri-implant infection is one of the biggest reasons that lead to dental implant failure. However, the existing antibacterial coating on titanium usually showed a rapid decrease in antibacterial efficiency.…”

Layer‐by‐Layer Assembled Smart Antibacterial Coatings via Mussel‐Inspired Polymerization and Dynamic Covalent Chemistry

“…[3,4] Therefore, the development of smart and robust antibacterial coatings has attracted great attentions during the past decade, owing to their efficient antibacterial activities and facile surface engineering process without damaging the substrates. [5] Several fabrication strategies toward functional antimicrobial coatings have been widely developed so far, including Langmuir-Blodgett (LB) deposition, Langmuir-Schaefer (LS) deposition, and Layer-by-Layer (LBL) assembly. [6,7] In addition, several kinds of dry methods have also widely used for the preparation of antimicrobial coatings, such as radical-rich plasma activated coatings.…”

Surface Engineering Strategies to Enhance the In Situ Performance of Medical Devices Including Atomic Scale Engineering

“…Antibacterial analysis for this functionalised surface was studied against S. aureus and Pseudomonas gingivalis. The results suggest that Ti-PAA-NCl is capable of inhibiting 96% of S. aureus and 91% of P. gingivalis [120]. In another investigation, silver nanoparticle AgNPs were incorporated in CaP-coated zirconia ceramics.…”