Long Latency Auditory Evoked Potential in Term and Premature Infants

Abstract

Introduction The research in long latency auditory evokes potentials (LLAEP) in newborns is recent because of the cortical structure maturation, but studies note that these potentials may be evidenced at this age and could be considered as indicators of cognitive development. Purpose To research the exogenous potentials in term and premature infants during their first month of life. Materials and Methods The sample consisted of 25 newborns, 15 term and 10 premature infants. The infants with gestational age under 37 weeks were considered premature. To evaluate the cortical potentials, the infants remained in natural sleep. The LLAEPs were researched binaurally, through insertion earphones, with frequent /ba/ and rare /ga/ speech stimuli in the intensity of 80 dB HL (decibel hearing level). The frequent stimuli presented a total of 80% of the presentations, and the rare, 20%. The data were statistically analyzed. Results The average gestational age of the term infants was 38.9 weeks (± 1.3) and for the premature group, 33.9 weeks (± 1.6). It was possible to observe only the potentials P1 and N1 in both groups, but there was no statistically significant difference for the latencies of the components P1 and N1 (p > 0.05) between the groups. Conclusion It was possible to observe the exogenous components P1 and N1 of the cortical potentials in both term and preterm newborns of no more than 1 month of age. However, there was no difference between the groups.

Audição e linguagem em crianças nascidas a termo e pré-termo

“…The positive wave 1 (P1), negative 1 (N1), positive 2 (P2) are part of CAEP, which are called exogenous components of the Long Latency Auditory Evoked Potential (LLAEP), as they are influenced by the physical characteristics of the stimulus, such as intensity, duration and frequency (4) and they do not depend on any response of the evaluated subject (3) . CAEP emerged as a procedure that is able to measure the degree of maturation of the central auditory pathways in an objective way by analyzing the changes concerning morphology and latency values of P1-P2-N1 components, over time (4,5) . In newborns and smaller children, P1 and N1 are the predominant potentials (5,6) .…”

“…CAEP emerged as a procedure that is able to measure the degree of maturation of the central auditory pathways in an objective way by analyzing the changes concerning morphology and latency values of P1-P2-N1 components, over time (4,5) . In newborns and smaller children, P1 and N1 are the predominant potentials (5,6) . On the other hand, the onset of other components would be related to the progressive maturation of central auditory pathways (5,6) .…”

“…In newborns and smaller children, P1 and N1 are the predominant potentials (5,6) . On the other hand, the onset of other components would be related to the progressive maturation of central auditory pathways (5,6) . It is noteworthy that the wave P1 was established as a biomarker to evaluate the auditory maturation (7,8) .…”

“…Regarding CAEP in this population, there is still the need to know more about potential features. Although some studies have already characterized, it is necessary to expand the knowledge in the pediatric population (5,9,16,17) , because in the literature there are a few longitudinal studies that analyze changes in morphology and latency of waves over time.…”

Potenciais evocados auditivos de tronco encefálico e de longa latência em crianças com tronstornos do espectro do autismo

“…As avaliações eletrofisiológicas podem ser realizadas em várias faixas etárias, sendo de grande relevância principalmente durante o desenvolvimento linguístico e para observação da integridade das estruturas centrais da audição, como por exemplo, os PEALL que avaliam o processamento auditivo central (Garcia et al, 2013). O P3 é um PEALL em que a resposta obtida é dada a partir da detecção de estímulos raros entre estímulos frequentes, envolvendo, portanto, uma resposta cognitiva por parte do indivíduo que está sendo avaliado.…”