Long non-coding RNA LINC01133 inhibits epithelial–mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6

Kong, Jie; Sun, Wenjie; Li, Chen; Wan, Ledong; Wang, Shuo; Wu, Yihua; Xu, Enbo; Zhang, Honghe; Lai, Maode

doi:10.1016/j.canlet.2016.07.015

Cited by 169 publications

(167 citation statements)

References 29 publications

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“…The patient characteristics are shown in Supplemental Table 1 (supplemental material available online with this article; https://doi.org/10.1172/JCI96218DS1). As shown in Figure 1A, the microarray analysis identified 158 upregulated and 142 downregulated lncRNAs from 7,419 analyzed lncRNAs in the MIBC tissues, including CASC9, MIAT, MEG3, and LINC01133, which are associated with human cancer progression (25)(26)(27)(28). Additionally, one lncRNA (LINC00958, RefSeq accession number NR_038904), Figure 1.…”

Section: Blacat2 Overexpression Correlates With Ln Metastasis Of Bladmentioning

confidence: 99%

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

Wang¹,

Zhong²,

Jiang³

et al. 2018

Journal of Clinical Investigation

160

151

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Section: Blacat2 Overexpression Correlates With Ln Metastasis Of Bladmentioning

confidence: 99%

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

Wang¹,

Zhong²,

Jiang³

et al. 2018

Journal of Clinical Investigation

160

151

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“…Knockdown of LINC01133 significantly inhibits the migration and invasion capacity of lung cancer cells and osteosarcoma cells by targeting EZH2, LSD1, and sponging miR-422a [18,19]. Interestingly, two recent studies have shown that LINC01133 expression is lost in colorectal cancer, and the silencing of LINC01133 suppresses metastasis and epithelial-mesenchymal transition by interacting with SRSF6 [20,21]. These contradictory results suggest that LINC01133 exerts both a positive and negative effect on migration and invasion in a tumor type-dependent manner.…”

Section: Introductionmentioning

confidence: 87%

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

Yang

Tien

et al. 2018

Cell Physiol Biochem

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Background/Aims: Considerable evidence indicates that long noncoding RNAs (lncRNAs) exert importantly regulatory functions during human cancer initiation and progression and are promising biotargets in the flight against cancer. Methods: In this study, we evaluated the role of the lncRNA LINC01133 in esophageal squamous cell carcinoma (ESCC). LINC01133 expression in ESCC was examined by quantitative real-time PCR. The correlations between LINC01133 expression and clinicopathological variables and survival were examined by the χ² test, Kaplan–Meier method, log-rank test, and univariate Cox regression analysis. Results: LINC01133 expression levels were frequently lower in ESCC tissues and cell lines than in paired normal tissues and an immortalized esophageal epithelial cell line, respectively. The expression of LINC01133 decreased in a TNM stage- and lifestyle-independent manner. LINC01133 was an independent protective factor and had an anti-tumor effect in the early stage of ESCC development. More importantly, we discovered that drinking status in our cohort impaired the predictive accuracy of LINC01133 for patients with ESCC. Furthermore, a new risk model combining LINC01133 expression, drinking status, and TNM stage provided better survival discrimination compared with three other predictors. Conclusions: Our data indicate that a loss of LINC01133 expression is a potential poor prognostic biomarker and therapeutic target for ESCC and provide additional prognostic information to improve the outcomes of ESCC patients.

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“…50 Cells were treated with recombinant human S100A8 protein (rhS100A8, Proteintech, China) at 0, 0.1, 1, 2, and 4 mg/mL for 48 h.…”

Section: Cell Culturesmentioning

confidence: 99%

S100A8⁺stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma

et al. 2016

OncoImmunology

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Gene microarray and bioinformatic analysis showed that S100A8 was more abundant in the stroma surrounding tumor buddings (TBs) than in the stroma surrounding primary tumor cells in colorectal carcinomas. Here, S100A8C cells in 419 colorectal carcinoma samples were stained by immunohistochemistry and counted using Image-pro plus 6.0. TBs were also counted and biomarkers associated with the epithelial-mesenchymal transition and apoptosis were assessed by immunohistochemistry. We evaluated the association between S100A8C cells and clinico-pathological variables as well as survival. Migration and invasion as well as biomarkers of the epithelial-mesenchymal transition and apoptosis were tested in CRC cells, treated with graded concentrations of recombinant human S100A8 protein.We found that the density of S100A8 C cells in the tumor invasive front (S100A8 C TIF ) clearly distinguished patients with 5-y survival from those who did not survive (p D 0.01). The S100A8 C -associated tumor budding (SATB) index determined by the S100A8 C TIF and TB was an independent predictor of overall survival (p D 0.001) other than the S100A8 C TIF or TB alone. Migration and invasion properties of CRC cells were inhibited by recombinant human S100A8 treatment. The particular S100A8C cells in the stroma were associated with important biomarkers of the epithelial-mesenchymal transition (E-cadherin and SNAIL) and apoptosis (BCL2).In conclusion, S100A8 C cells in the stroma predict a good prognosis in colorectal carcinoma. An index combining S100A8C cells and TB independently predicts survival. Recombinant human S100A8 inhibited CRC cell migration and invasion, which was involved in epithelial-mesenchymal transition (E-cadherin and SNAIL) and apoptosis (BCL2).

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Long non-coding RNA LINC01133 inhibits epithelial–mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6

Cited by 169 publications

References 29 publications

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

S100A8⁺stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma

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Long non-coding RNA LINC01133 inhibits epithelial–mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6

Cited by 169 publications

References 29 publications

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

Predictive Value of LINC01133 for Unfavorable Prognosis was Impacted by Alcohol in Esophageal Squamous Cell Carcinoma

S100A8+stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma

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S100A8⁺stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma