Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives

Yang, Yanlei; Liu, Suying; He, Chengmei; Chen, Zhilei; Lyu, Taibiao; Zeng, Liuting; Wang, Li; Zhang, Fengchun; Chen, Hua; Zhao, Robert Chunhua

doi:10.3389/fcell.2021.711005

Cited by 7 publications

(6 citation statements)

References 132 publications

(154 reference statements)

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“…A complex interaction of genetic and epigenetic factors also controls the differentiation process. Genetic factors include the expression of particular transcription factors and signaling molecules, while epigenetic factors include histone modification, DNA methylation, and altered expression of non-coding RNA ( 53 ).…”

Section: Mscs and Stem Cellsmentioning

confidence: 99%

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Liu

et al. 2023

Front. Endocrinol.

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Diabetes has become a global public health problem. Diabetic foot is one of the most severe complications of diabetes, which often places a heavy economic burden on patients and seriously affects their quality of life. The current conventional treatment for the diabetic foot can only relieve the symptoms or delay the progression of the disease but cannot repair damaged blood vessels and nerves. An increasing number of studies have shown that mesenchymal stem cells (MSCs) can promote angiogenesis and re-epithelialization, participate in immune regulation, reduce inflammation, and finally repair diabetic foot ulcer (DFU), rendering it an effective means of treating diabetic foot disease. Currently, stem cells used in the treatment of diabetic foot are divided into two categories: autologous and allogeneic. They are mainly derived from the bone marrow, umbilical cord, adipose tissue, and placenta. MSCs from different sources have similar characteristics and subtle differences. Mastering their features to better select and use MSCs is the premise of improving the therapeutic effect of DFU. This article reviews the types and characteristics of MSCs and their molecular mechanisms and functions in treating DFU to provide innovative ideas for using MSCs to treat diabetic foot and promote wound healing.

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Section: Mscs and Stem Cellsmentioning

confidence: 99%

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Liu

et al. 2023

Front. Endocrinol.

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“…Efficient and targeted delivery of MSC-derived lncRNAs to the injured heart is critical for therapeutic success. Strategies that enhance tissue specificity, improve delivery efficiency, and minimize potential adverse effects need to be developed [ 121 , 122 ]. Before clinical translation, rigorous safety assessments are necessary to evaluate potential toxicities, off-target effects, and long-term consequences of MSC-derived lncRNA-based therapies.…”

Section: Challenges and Future Prospects For Utilizing Msc-derived Ln...mentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair

Tran,

Cruz,

Chan

et al. 2023

Cells

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Cardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cardiac regeneration due to their ability to differentiate into various cell types and secrete bioactive molecules. In recent years, attention has been given to noncoding RNAs derived from MSCs, particularly long noncoding RNAs (lncRNAs), and their potential role in cardiac injury and repair. LncRNAs are RNA molecules that do not encode proteins but play critical roles in gene regulation and cellular responses including cardiac repair and regeneration. This review focused on MSC-derived lncRNAs and their implications in cardiac regeneration, including their effects on cardiac function, myocardial remodeling, cardiomyocyte injury, and angiogenesis. Understanding the molecular mechanisms of MSC-derived lncRNAs in cardiac injury and repair may contribute to the development of novel therapeutic strategies for treating cardiovascular diseases. However, further research is needed to fully elucidate the potential of MSC-derived lncRNAs and address the challenges in this field.

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“…This special processing might offer a new oncogenic driver or tumor-suppressive function for GBM progression. The alternative splicing process events generate new lncRNAs involved in GBM pathogenesis and oncogenesis ( Wang et al, 2021 ; Yang et al, 2021 ).…”

Section: Classification Of Lncrnamentioning

confidence: 99%

Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

Liu

Chen

Wang

et al. 2022

Front. Cell Dev. Biol.

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Glioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients. Thus, there is an urgent requirement to characterize more biomarkers for the early diagnosis of GBM patients. In addition, the detailed molecular basis during GBM pathogenesis and oncogenesis is not fully understood, highlighting that it is of great significance to elucidate the molecular mechanisms of GBM initiation and development. Recently, accumulated pieces of evidence have revealed the central roles of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of GBM by binding with DNA, RNA, or protein. Targeting those oncogenic lncRNAs in GBM may be promising to develop more effective therapeutics. Furthermore, a better understanding of the biological function and underlying molecular basis of dysregulated lncRNAs in GBM initiation and development will offer new insights into GBM early diagnosis and develop novel treatments for GBM patients. Herein, this review builds on previous studies to summarize the dysregulated lncRNAs in GBM and their unique biological functions during GBM tumorigenesis and progression. In addition, new insights and challenges of lncRNA-based diagnostic and therapeutic potentials for GBM patients were also introduced.

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Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives

Cited by 7 publications

References 132 publications

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair

Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

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