Long Noncoding RNA<i>MEG3</i>Negatively Regulates Proliferation and Angiogenesis in Vascular Endothelial Cells

He, Chao; Yang, Wei; Yang, Jun; Ding, Jiawang; Li, Song; Wu, Hui; Zhou, Fei; Jiang, Yurong; Teng, Lin; Yang, Jian

doi:10.1089/dna.2017.3682

Cited by 94 publications

(66 citation statements)

References 29 publications

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“…Many studies have indicated that the aberrant expression of lncRNAs plays an important role in several disease related to vascular endothelial cells . For example, lncRNA‐MEG3 negatively regulating miR‐9 had the function on regulating the proliferation and angiogenesis of vascular endothelial cells . LncRNA‐MALAT1 could effectively attenuate oxygen‐glucose deprivation and re‐oxygenation‐induced apoptosis of HBMECs .…”

Section: Discussionmentioning

confidence: 99%

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

et al. 2018

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Section: Discussionmentioning

confidence: 99%

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

et al. 2018

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“…Emerging evidences have shown that the deletion or promoter hypermethylation of the MEG3 gene promotes angiogenesis . He et al found that MEG3 suppressed the proliferation and angiogenesis of vascular endothelial cells through the interaction and suppression of miR‐9 . Angiogenesis is one of the important mechanisms for the progression of MM …”

Section: Mechanisms Of Lncrnas In MMmentioning

confidence: 99%

The role of long non‐coding RNAs in multiple myeloma

Cui

Song

Fang

2019

European J of Haematology

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Multiple myeloma (MM) is still an incurable disease, and its pathogenesis involves cytogenetics and epigenetics. In recent years, the roles of long non‐coding RNAs (lncRNAs) in MM have been deeply studied by scholars. LncRNAs are defined as a class of non‐protein‐coding transcripts greater than 200 nucleotides in length, which are involved in a large spectrum of biological processes, including proliferation, differentiation, apoptosis, invasion, and chromatin remodeling. However, little is known about the specific mechanisms of these lncRNAs. They can act as oncogenic and/or tumor‐suppressive factors in the development and progression of MM. But that how do they work remains unclear. In this review, the recent progress in the study of functional lncRNAs associated with MM was summarized and the present knowledge about their expression and roles was discussed, to provide guidance for the in‐depth functional study of lncRNAs.

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“…Besides, increasing MEG3 expression not only restrained proliferation but also showed a negative effect on proliferation and angiogenesis in VEC. Through further study, MEG3 exerts its tumor suppression effect by playing a miRNA sponge to regulate miR-9 [61]. These studies above suggested that MEG3 might control double effect on inhibition of CRC proliferation by impeding angiogenesis in VEC.…”

Section: The Role Of Lncrnas In Crcmentioning

confidence: 99%

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Sun¹,

Wang²,

Chen³

et al. 2018

Cell Physiol Biochem

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Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future.

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Long Noncoding RNAMEG3Negatively Regulates Proliferation and Angiogenesis in Vascular Endothelial Cells

Cited by 94 publications

References 29 publications

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

The role of long non‐coding RNAs in multiple myeloma

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

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