Long Noncoding RNA: Recent Updates in Atherosclerosis

Li, Hao; Zhu, Hongming; Ge, Junbo

doi:10.7150/ijbs.14430

Cited by 87 publications

(82 citation statements)

References 91 publications

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“…Among yet, microRNAs (miRNAs) have been extensively studied, while little is known about the role of long ncRNAs (lncRNAs). Recent studies have partially revealed the regulatory functions of lncRNAs in complex human diseases, such as a variety of cancers [7], neurological disorder [8] and atherosclerosis [9]. Further investigations indicate that lncRNAs may regulate the biological processes of atherosclerosis-related endothelial cells, especially angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Silence of lncRNA UCA1 Represses the Growth and Tube Formation of Human Microvascular Endothelial Cells Through miR-195

Yin

Sun

2018

Cell Physiol Biochem

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Background/Aims: Recent studies have suggested that several lncRNAs contribute to the angiogenic function of endothelial cells. Herein, we set out to reveal whether lncRNA UCA1 has functions in endothelial angiogenesis. Methods: The expression levels of lncRNA UCA1, miR-195 and CCND1 in human microvascular endothelial HMEC-1 cells were altered by transfection. Subsequently, cell viability, migration, tube formation and apoptosis of HMEC-1 cells were respectively assessed. The cross-talk between lncRNA UCA1, miR-195, CCND1, and MEK/ERK and mTOR signaling pathways were investigated by performing qRT-PCR and Western blotting. Results: Silence of lncRNA UCA1 repressed HMEC-1 cells viability, migration, tube formation, and induced apoptosis. Meanwhile, silence of lncRNA UCA1 significantly up-regulated miR-195 expression. These alterations induced by lncRNA UCA1 were further enhanced by miR-195 overexpression, while were attenuated by miR-195 suppression. Moreover, silence of lncRNA UCA1 deactivated MEK/ERK and mTOR signaling pathways via a miR-195-dependent regulation. And the deactivation of MEK/ERK and mTOR signaling pathways led to a down-regulation of CCND1. Conclusion: This study demonstrates that silence of lncRNA UCA1 largely represses microvascular endothelial cells growth and tube formation. Silence of lncRNA UCA1 exerts its function possibly via up-regulation of miR-195, which in turn inactivates MEK/ERK and mTOR signaling pathways, and ultimately represses CCND1 expression.

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Section: Introductionmentioning

confidence: 99%

Silence of lncRNA UCA1 Represses the Growth and Tube Formation of Human Microvascular Endothelial Cells Through miR-195

Yin

Sun

2018

Cell Physiol Biochem

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“…LncRNA has also been shown to be involved in pathological vascular conditions such as atherosclerosis [58], microvascular disorders [59], diabetic retinopathies [60], pulmonary hypertension [61], and myocardial infarction [62]. LncRNA ANRIL is transcribed from INK/ARF locus, which is expressed in atherosclerotic tissues and cells such as primary coronary smooth muscle cells, vascular endothelial cells, human monocyte-derived macrophage cells, and carotid myocytes [59].…”

Section: Lncrna and Vascular Pathologiesmentioning

confidence: 99%

LncRNA as a Therapeutic Target for Angiogenesis

Kumar

Goyal

2017

CTMC

213

152

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Background: Out of 3 billion base pairs in human genome only ~2% code for proteins; and out of 180,000 transcripts in human cells, about 20,000 code for protein, remaining 160,000 are non-coding transcripts. Most of these transcripts are more than 200 base pairs and constitute a group of long non-coding RNA (lncRNA). Many of the lncRNA have its own promoter, and are well conserved in mammals. Accumulating evidence indicates that lncRNAs act as molecular switches in cellular differentiation, movement, apoptosis, and in the reprogramming of cell states by altering gene expression patterns. However, the role of this important group of molecules in angiogenesis is not well understood. Angiogenesis is a complex process and depends on precise regulation of gene expression. Conclusion:Dysregulation of transcription during this process may lead to several diseases including various cancers. As angiogenesis is an important process in cancer pathogenesis and treatment, lncRNA may be playing an important role in angiogenesis. In support of this, lncRNA microvascular invasion in hepatocellular carcinoma (MVIH) has been shown to activate angiogenesis. Furthermore, lncRNA-Meg3-knockout mouse showed increased expression of vascular endothelial growth factor pathway genes and increased cortical microvessel density. Overall, there is strong evidence that lncRNA is an important class of regulatory molecule, and a number of studies have demonstrated that these can be targeted to change cellular physiology and functions. In this review, we have attempted to summarize these studies and elucidate the potential of this novel regulatory molecule as a therapeutic target.

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“…LncRNAs have a poorly conserved primary structure but relatively well‐conserved secondary structure and splicing . The mechanisms of action of lncRNAs are diverse and not yet fully understand, but mainly include genetic imprinting, chromatin remodeling, cell cycle regulation, splicing regulation, mRNA degradation and translation regulation . LncRNAs have been shown to control every level of the regulation of the gene expression pathway .…”

Section: Lncrnas and Their Mechanisms Of Actionmentioning

confidence: 99%

“…26,27 The mechanisms of action of lncRNAs are diverse and not yet fully understand, but mainly include genetic imprinting, chromatin remodeling, cell cycle regulation, splicing regulation, mRNA degradation and translation regulation. 28,29 LncRNAs have been shown to control every level of the regulation of the gene expression pathway. 24 An overview of the cellular functions of lncRNAs is shown in Figure 1.…”

Section: Lncrnas and Their Mechanisms Of Actionmentioning

confidence: 99%

Long noncoding RNA and its contribution to autism spectrum disorders

Jing

Yang

2017

CNS Neurosci Ther

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Recent studies have indicated that long noncoding RNAs (lncRNAs) play important roles in multiple processes, such as epigenetic regulation, gene expression regulation, development, nutrition-related and other diseases, toxic response, and response to drugs. Although the functional roles and mechanisms of several lncRNAs have been discovered, a better understanding of the vast majority of lncRNAs remains elusive. To understand the functional roles and mechanisms of lncRNAs is critical because these transcripts represent the majority of the transcriptional output of the mammalian genome. Recent studies have also suggested that lncRNAs are more abundant in the human brain and are involved in neurodevelopment and neurodevelopmental disorders, including autism spectrum disorders (ASDs). In this study, we review several known functions of lncRNAs and the potential contribution of lncRNAs to ASDs and to other genetic syndromes that have a similar clinical presentation to ASDs, such as fragile X syndrome and Rett syndrome.

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Long Noncoding RNA: Recent Updates in Atherosclerosis

Cited by 87 publications

References 91 publications

Silence of lncRNA UCA1 Represses the Growth and Tube Formation of Human Microvascular Endothelial Cells Through miR-195

Silence of lncRNA UCA1 Represses the Growth and Tube Formation of Human Microvascular Endothelial Cells Through miR-195

LncRNA as a Therapeutic Target for Angiogenesis

Long noncoding RNA and its contribution to autism spectrum disorders

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