Long‐Pulsed Nd:YAG (1,064 nm) Laser Versus Q‐Switched Nd:YAG (1,064 nm) Laser for Treatment of Onychomycosis

Elmorsy, Eman H.; Khadr, Nouran A. Abou; Taha, Alsayeda A.A.; Aziz, Doaa M. Abdel

doi:10.1002/lsm.23200

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…Such results were also in agreement with Elmorsy et al, who concluded in their studies that both Q‐Switched Nd:YAG (1064 nm) and long‐ pulsed Nd:YAG (1064 nm) lasers are effective and safe modalities in the treatment of onychomycosis, especially in patients who have a contraindication to the use of oral antifungals 19 …”

Section: Discussionsupporting

confidence: 90%

Q‐switched Nd:YAGlaser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study

Amin

Ragaie

2023

J of Cosmetic Dermatology

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Background: Onychomycosis (OM) represents about 50% of nail disorders. Oral antifungals have proven efficacy in the treatment of onychomycosis but their associated side effects limit their use. Accordingly, there is an increased need for a safe and effective therapy to induce clearance and improve the esthetic appearance of diseased nails.Objective: The current study is an attempt to evaluate and compare the efficacy of Q-Switched Nd:YAG (1064 nm) laser as monotherapy versus pulse itraconazole in the clearance of onychomycosis. How to cite this article: Nasif GA, Amin AA, Ragaie MH. Q-switched Nd:YAG laser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study.

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Section: Discussionsupporting

confidence: 90%

Q‐switched Nd:YAGlaser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study

Amin

Ragaie

2023

J of Cosmetic Dermatology

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“…The efficiency of such treatment is limited since the nail plate is an effective barrier for the delivery of local pharmaceuticals to the nail bed affected by the fungus [4,5]. Laser radiation can also be used for the treatment of onychomycosis [6‐9].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum

2021

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Background and Objective A novel dual‐stage method for active laser drug delivery (DSLADD) in the treatment of nail diseases is being presented. This method includes sequentially performed microporation of the nail with submillisecond pulses of Er:YLF laser radiation through a layer of an aqueous solution of drug deposited on the nail surface (Stage 1) and exposure this layer to the same laser radiation to deliver drug under the nail plate (Stage 2). The delivery of methylene blue (MB) as one of the possible drugs in the treatment of nail diseases is investigated. The influence of the thickness of the MB layer, as well as the energy and number of applied laser pulses, on the rate of active laser delivery is discussed. To illustrate the possible effect of delivery on the drug delivered, special attention is paid to the deformation of the extinction spectrum of MB solution after laser irradiation. Study Design/Materials and Methods Diode‐pumped Er:YLF laser was used for DSLADD. The process of DSLADD under the nail plate was investigated using digital video microscopy. For different values of the thickness of MB solution layer applied to the nail plate and the energy of laser pulses, the number of laser pulses required to create a single through a microchannel in the nail plate and the number of laser pulses required to deliver the solution to the ventral side of the nail plate after its microporation were registered. The mass and the dose of MB solution penetrated under the nail plate, and the rate of MB solution delivery through a single microchannel was determined. Investigation of the influence of Er:YLF laser radiation parameters on the extinction spectrum of the drug was performed using a fiber spectrometer. The extinction spectra of the 0.001% aqueous solution of MB were recorded before and after exposure to a different number of Er:YLF laser pulses with the energy of 1–4 mJ. Results It was found that the minimum number of laser pulses required for active Er:YLF laser drug delivery under the nail corresponds to the MB layer thickness of 100 μm and the laser pulse energy of 4 mJ. It is shown that in this case, the rate of active laser delivery of MB solution reaches 0.26 ± 0.03 mg/pulse. The radiation of the Er:YLF laser affects the shape of the extinction spectrum of the aqueous solution of MВ, which is associated with the transition of the dye from the monomeric to dimeric state. Depending on the laser pulse energy, the fraction of a certain conformational state in the aqueous MB solution can decrease or increase, stimulating a possible change in its photodynamic and antiseptic activity. Conclusion For the first time, a novel DSLADD through the nail has been described and investigated in vitro. It was demonstrated that at Er:YLF laser pulse repetition rate of f = 30 Hz, microporation of the nail plate and drug delivery through a single microchannel will be about 1.5 s. Lasers Surg. Med. © 2021 Wiley Periodicals LLC

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“…It has the advantage of being able to treat deep fungal infections. In recent years, the Nd:YAG laser has mostly been used to treat onychomycoses ( 9 ), Candida albicans ( 10 ), chromomycosis ( 11 ), warts ( 12 ), and some vascular and pigmentary diseases ( 13 ). In our early clinical study, we found that utilizing the Nd:YAG 1,064-nm laser as an additional treatment shortened the duration of sporotrichosis therapy, reduced the amount of azole antifungal drugs used, and decreased drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of a Neodymium-Doped Yttrium Aluminum Garnet 1,064-Nanometer Laser against Sporothrix globosa by Inducing Apoptosis and Pyroptosis via the NLRP3/Caspase-1 Signaling Pathway: In Vitro and In Vivo Study

Yan

et al. 2021

Microbiol Spectr

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Long‐Pulsed Nd:YAG (1,064 nm) Laser Versus Q‐Switched Nd:YAG (1,064 nm) Laser for Treatment of Onychomycosis

Cited by 11 publications

References 22 publications

Q‐switched Nd:YAGlaser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study

Q‐switched Nd:YAGlaser versus itraconazole pulse therapy in treatment of onychomycosis: A clinical dermoscopic and mycologic study

Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum

Antifungal Activity of a Neodymium-Doped Yttrium Aluminum Garnet 1,064-Nanometer Laser against Sporothrix globosa by Inducing Apoptosis and Pyroptosis via the NLRP3/Caspase-1 Signaling Pathway: In Vitro and In Vivo Study

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