Long-term antibacterial activity of a composite coating on titanium for dental implant application

Cheng, Yicheng; Mei, Shenglin; Kong, Xiangdong; Liu, Xianghui; Gao, Bo; Chen, Bin; Wu, Jiang

doi:10.1177/0885328220963934

Cited by 8 publications

(9 citation statements)

References 40 publications

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“…Biomaterials have been remarkably developed over the last years, targeting improvements in tissue engineering, immunotherapy, and drug delivery sphere [ 43 , 44 , 45 , 46 ]. Biological response, especially to implanted materials, are major concern to successfully achieve regenerative purposes.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds

et al. 2021

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Guided bone regeneration involves excluding non-osteogenic cells from the surrounding soft tissues and allowing osteogenic cells originating from native bone to inhabit the defect. The aim of this work was to fabricate, analyze antibiofilm activity and evaluate in vivo biological response of poly (lactic-co-glycolic acid) (PLGA) electrospun membranes incorporated with tea tree oil and furan-2(5H)-one. Samples were exposed to Streptococcus mutans culture and after 48 h incubation, biofilm was evaluated by colony forming units (CFU/mL) followed by scanning electron microscopy. Additionally, seventy-five Balb-C mice were divided into five experimental groups for subcutaneous implantation: tea tree oil loaded PLGA electrospun fiber membrane, furanone loaded PLGA electrospun fiber membrane, neat PLGA electrospun fiber membrane, a commercially available PLGA membrane –Pratix® and Sham (no-membrane implantation). Post implantation period of each experimental group (1, 3 and 9 weeks), samples were collected and processed for by histological descriptive and semiquantitative evaluation. Results showed a significant reduction of bacterial attachment on tea tree oil and furan-2(5H)-one incorporated membranes. Macrophage counts were significant found in all the materials implanted, although giant cells were predominantly associated with electrospun fiber membranes. The incorporation of antibiofilm compounds in nanofibers membranes did not incite inflammatory response significantly different in comparison with pure PLGA electrospun membranes, indicating its potential for development of novel functionalized membranes targeting the inhibition of bacterial biofilms on membrane-grafting materials.

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Section: Discussionmentioning

confidence: 99%

In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds

et al. 2021

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“…Despite some promising results using these coatings, newer implant methods are required due to the absence of long-lasting antibacterial effects and the emergence of drug-resistant microbes [37]. Previous studies have shown that TESPSA 27 , polydopamine, silver nanoparticles [28], BBF (a composite coating containing a new antibacterial agent (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone) [38], as well as black phosphorus-zinc oxide nanohybrids [33], all have potential as antibacterial coatings for dental implant surfaces.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Efficacy and Surface Characteristics of Boron Nitride Coated Dental Implant: An In-Vitro Study

Raval

Yadav

Narwani

et al. 2023

JFB

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This in vitro study evaluated bacterial cell proliferation and biofilm adhesion on titanium discs with and without antibacterial surface treatment to reduce the chances of peri-implant infections. Hexagonal boron nitride with 99.5% purity was converted to hexagonal boron nitride nanosheets via the liquid phase exfoliation process. The spin coating method was used for uniform coating of h-BNNSs over titanium alloy (Ti6Al4V) discs. Two groups of titanium discs were formed: Group I (n = 10) BN-coated titanium discs and Group II (n = 10) uncoated titanium discs. Two bacterial strains, Streptococcus mutans (initial colonizers) and Fusobacterium nucleatum (secondary colonizers), were used. A zone of inhibition test, microbial colony forming units assay, and crystal violet staining assay were used to evaluate bacterial cell viability. Surface characteristics and antimicrobial efficacy were examined by scanning electron microscopy with energy dispersion X-ray spectroscopy. SPSS (Statistical Package for Social Sciences) version 21.0 was used to analyze the results. The data were analyzed for probability distribution using the Kolmogorov-Smirnov test, and a non-parametric test of significance was applied. An inter-group comparison was done using the Mann-Whitney U test. A statistically significant increase was observed in the bactericidal action of BN-coated discs compared to uncoated discs against S. mutans, but no statistically significant difference was found against F. nucleatum.

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“…This feature of DAIs lays the basis for the development of antibacterial surfaces with long active durations. As shown by the representative reports on the development of “ long-term ” antibacterial surfaces ( Table 5 ) [ 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ], various ingredients such as commercial antibiotics (tigecycline, vancomycin, amoxicillin, etc.) [ 121 , 132 ], metals or metal ions (silver, copper, or zinc) [ 124 , 125 , 129 ], and other drugs [ 127 , 128 ] were taken to equip implantable biomaterials (titanium, silicone, ceramics, etc.)…”

Section: Innovative Designs To Mitigate Device-associated Infectionsmentioning

confidence: 99%

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

Cao

Qiao

Qin

2022

JFB

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The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.

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Long-term antibacterial activity of a composite coating on titanium for dental implant application

Cited by 8 publications

References 40 publications

In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds

In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds

Antibacterial Efficacy and Surface Characteristics of Boron Nitride Coated Dental Implant: An In-Vitro Study

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

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