Long‐term antibiofilm activity of carboxymethyl chitosan on mixed biofilm on silicone

Tan, Yulong; Leonhard, Matthias; Moser, Doris; Ma, Su; Schneider‐Stickler, Berit

doi:10.1002/lary.26096

Cited by 21 publications

(12 citation statements)

References 43 publications

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“…[1][2][3][4][5] Management of an implant-associated infection often necessitates multiple debridement surgeries, implant replacement or removal, and long-term antibiotic treatment. [6][7][8][9] These problems are aggravated in patients with bone healing disorders associated with rheumatoid arthritis, osteoporosis, diabetes, or aging due to the difficulty of clearing an infection from poorly vascularized bone tissues and other necrotic tissues. 3,5,10,11 Implant-associated infections are caused by bacterial adhesion to an implant surface and subsequent formation of biofilms around implanted devices.…”

Section: Introductionmentioning

confidence: 99%

<p>Nanosilver/poly (DL-lactic-co-glycolic acid) on titanium implant surfaces for the enhancement of antibacterial properties and osteoinductivity</p>

Zeng

Xiong

Zhuo

et al. 2019

IJN

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Background: Despite titanium (Ti) implants have been commonly used in the medical device field due to their superior biocompatibility, implant-associated bacterial infection remains a major clinical complication. Nanosilver, an effective antibacterial agent against a wide spectrum of bacterial strains, with a low-resistance potential, has attracted much interest too. Incorporation of nanosilver on Ti implants may be a promising approach to prevent biofilm formation. Purpose: The objective of the study was to investigate the antibacterial effects and osteoinductive properties of nanosilver/poly (dl-lactic-co-glycolic acid)-coated titanium (NSPTi). Methods: Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and the Gramnegative opportunistic pathogen Pseudomonas aeruginosa (PAO-1) were used to evaluate the antibacterial activity of NSPTi implants through the analysis of bacterial colonization in vitro and in vivo. Furthermore, we examined the osteoinductive potential of NSPTi implants by investigating the proliferation and differentiation of MC3T3-E1 preosteoblast cells. In vivo, the osteoinductive properties of NSPTi implants were assessed by radiographic evaluation, H&E staining, and Masson's trichrome staining. Results: In vitro, bacterial adhesion to the 2% NSPTi was significantly inhibited and ,1% of adhered bacteria survived after 24 hours. In vitro, the average colony-forming units (CFU)/g ratios in the 2% NSPTi with 10 3 CFU MRSA and PAO-1 were 1.50±0.68 and 1.75±0.6, respectively. In the uncoated Ti groups, the ratios were 1.03±0.82×10 3 and 0.94±0.49×10 3 , respectively. These results demonstrated that NSPTi implants had prominent antibacterial properties. Proliferation of MC3T3-E1 cells on the 2% NSPTi sample was 1.51, 1.78, and 2.22 times that on the uncoated Ti control after 3, 5, and 7 days' incubation, respectively. Furthermore, NSPTi implants promoted the maturation and differentiation of MC3T3-E1 cells. In vivo, NSPTi accelerated the formation of new bone while suppressing bacterial survival. Conclusion: NSPTi implants have simultaneous antibacterial and osteoinductive activities and therefore have the potential in clinical applications.

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Section: Introductionmentioning

confidence: 99%

<p>Nanosilver/poly (DL-lactic-co-glycolic acid) on titanium implant surfaces for the enhancement of antibacterial properties and osteoinductivity</p>

Zeng

Xiong

Zhuo

et al. 2019

IJN

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“…Similarly, carboxymethyl chitosan (CM-chitosan) might be a possible antibiofilm agent to be applied on voice prostheses. Tan and colleagues [158] performed several studies using this compound. They determined the influence of carboxymethyl chitosan on the mixed biofilm formation of C. albicans, C. tropicalis, L. gasseri, S. salivarius, R. dentocariosa, and S. epidermidis, on silicone over a long-term period.…”

Section: Innovative Treatments Of Other Diseasesmentioning

confidence: 99%

Candida spp./Bacteria Mixed Biofilms

Rodrigues

Gomes

Rodrigues

2019

JoF

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The ability to form biofilms is a common feature of microorganisms, such as bacteria or fungi. These consortiums can colonize a variety of surfaces, such as host tissues, dentures, and catheters, resulting in infections highly resistant to drugs, when compared with their planktonic counterparts. This refractory effect is particularly critical in polymicrobial biofilms involving both fungi and bacteria. This review emphasizes Candida spp.-bacteria biofilms, the epidemiology of this community, the challenges in the eradication of such biofilms, and the most relevant treatments.

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“…from adhering to surface of medicinal silicone rubber (such as voice prostheses) and inhibit the evolution of mixed fungi biofilm at different stages for a long period of time in vitro. 82 , 83 Recently, Tan et al have revealed that CM-chitosan has exerted a strong inhibitory effect on the biofilm formation of non- C. albicans species including C. tropicalis , Candida krusei , C. parapsilosis and C. glabrata , particularly on mixed-species biofilm. 84 Yet, there is pressing need for further studies to explore whether medicinal silicone coated with CM-chitosan has an inhibitory effect on mixed fungal biofilm in vivo.…”

Section: Other New Drugsmentioning

confidence: 99%

An insight into new strategies to combat antifungal drug resistance

Zheng

Ding

et al. 2018

DDDT

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Invasive fungal infections especially in immunocompromised patients represent a dominating cause of mortality. The most commonly used antifungal agents can be divided into three broad categories, including triazoles, echinocandins and polyenes. Antifungal resistance is on the increase, posing a growing threat to the stewardship of immunocompromised patients with fungal infections. The paucity of currently available antifungals leads to the rapid emergence of drug resistance and thus aggravates the refractoriness of invasive fungal infections. Therefore, deep exploration into mechanisms of drug resistance and search for new antifungal targets are required. This review highlights the therapeutic strategies targeting Hsp90, calcineurin, trehalose biosynthesis and sphingolipids biosynthesis, in an attempt to provide clinical evidence for overcoming drug resistance and to form the rationale for combination therapy of conventional antifungals and agents with novel mechanisms of action. What’s more, this review also gives a concise introduction of three new-fashioned antifungals, including carboxymethyl chitosan, silver nanoparticles and chromogranin A-N46.

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Long‐term antibiofilm activity of carboxymethyl chitosan on mixed biofilm on silicone

Abstract: NA Laryngoscope, 126:E404-E408, 2016.

Cited by 21 publications

References 43 publications

<p>Nanosilver/poly (DL-lactic-co-glycolic acid) on titanium implant surfaces for the enhancement of antibacterial properties and osteoinductivity</p>

<p>Nanosilver/poly (DL-lactic-co-glycolic acid) on titanium implant surfaces for the enhancement of antibacterial properties and osteoinductivity</p>

Candida spp./Bacteria Mixed Biofilms

An insight into new strategies to combat antifungal drug resistance

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