Long-Term Cancer-Specific and Overall Survival for Men Followed More Than 10 Years After Primary and Salvage Cryoablation of the Prostate

Cheetham, Philippa J.; Truesdale, Matthew D.; Chaudhury, Sawda; Wenske, Swen; Hruby, Gregory W.; Katz, Aaron E.

doi:10.1089/end.2010.0130

Cited by 42 publications

(19 citation statements)

References 28 publications

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“…If the prediabetic or diabetic state results in a more aggressive prostate cancer, 28,29 then immortality bias might contribute to why we did not find a significant increase risk of prostate cancer in the pre-diabetic period. However, we do not believe immortality bias is a major bias in our study, since most patients with prostate cancer survive beyond 10 years, 30 allowing for enough time to develop DM and be appropriately classified.…”

Section: Discussionmentioning

confidence: 83%

Prostate Cancer Risk in Pre-Diabetic Men: A Matched Cohort Study

Onitilo

Berg

Engel

et al. 2013

Clinical Medicine & Research

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Background: Diagnosis and duration of type 2 diabetes mellitus (DM) appear to be associated with decreased prostate cancer risk. Limitations of previous studies include methods of subject selection and accurate definition of DM diagnosis. We examined the temporal relationship between DM and prostate cancer risk exploring the period of greatest risk starting from the prediabetic to the postdiabetic period using clinical and administrative data to accurately define the date of DM diagnosis.

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Section: Discussionmentioning

confidence: 83%

Prostate Cancer Risk in Pre-Diabetic Men: A Matched Cohort Study

Onitilo

Berg

Engel

et al. 2013

Clinical Medicine & Research

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Section: Discussionmentioning

confidence: 99%

“…Single-centre reports with long-term oncological outcome data have been published recently [20,21] . According to the cohort from Columbia University (51 patients), the 10-year disease-specific mortality was 15.5% [20] . Analysis of the updated oncological outcome for patients treated at the University of Western Ontario revealed a 10-year bDFS of 39% [21] .…”

Section: Discussionmentioning

confidence: 99%

Third-Generation Salvage Cryotherapy for Radiorecurrent Prostate Cancer: A Centre’s Experience

Philippou

Yap²,

Chinegwundoh³

2012

Urol Int

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Introduction: The experience of a tertiary centre in the management of recurrent prostate cancer after radiotherapy by salvage cryotherapy is presented. Patients and Methods: Between February 2006 and August 2008, 19 patients underwent salvage cryotherapy for radiorecurrent prostate cancer. Post-radiotherapy recurrence was confirmed by prostatic biopsy. The ‘Phoenix definition’ was used to define biochemical failure after salvage cryotherapy. Results: The mean age at cryotherapy was 69.2 years and the mean time from radiotherapy to cryotherapy was 72.3 months. Patient characteristics prior to cryotherapy included a mean PSA level of 6.84 ng/ml and a median Gleason score of 7. The mean post-cryotherapy follow-up was 33.3 months. The 2-year biochemical disease-free survival rate was 58%. The median post-cryotherapy PSA nadir was 0.20 ng/ml (range 0.005–8.260). There were no procedure-related or cancer-related deaths. Complications included incontinence (10.5%), erectile dysfunction (89%) and fistula formation (5.3%). Conclusions: The relatively high rates of biochemical response support the use of cryotherapy as a salvage procedure for radiorecurrent prostate cancer.

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“…[1][2][3][4] Cryotherapy has gained acceptance as a clinical tool for the treatment of internal malignancies, including carcinomas of the prostate. [5][6][7][8][9] This method of tissue ablation belongs to a larger category of thermal therapies and causes cancer cells to undergo coagulative necrosis as a result of deep freezing. A modern cryosurgical procedure employs thin cryoprobes (needles) of about 1.5 to 3 mm in diameter, which are precisely positioned near the cancerous tissue guided by ultrasound (US) imaging.…”

Section: Introductionmentioning

confidence: 99%

Imaging technique for real-time temperature monitoring during cryotherapy of lesions

et al. 2016

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Abstract. Noninvasive real-time temperature imaging during thermal therapies is able to significantly improve clinical outcomes. An optoacoustic (OA) temperature monitoring method is proposed for noninvasive real-time thermometry of vascularized tissue during cryotherapy. The universal temperature-dependent optoacoustic response (ThOR) of red blood cells (RBCs) is employed to convert reconstructed OA images to temperature maps. To obtain the temperature calibration curve for intensity-normalized OA images, we measured ThOR of 10 porcine blood samples in the range of temperatures from 40°C to −16°C and analyzed the data for single measurement variations. The nonlinearity (ΔT max ) and the temperature of zero OA response (T 0 ) of the calibration curve were found equal to 11.4 AE 0.1°C and −13.8 AE 0.1°C, respectively. The morphology of RBCs was examined before and after the data collection confirming cellular integrity and intracellular compartmentalization of hemoglobin. For temperatures below 0°C, which are of particular interest for cryotherapy, the accuracy of a single temperature measurement was AE1°C, which is consistent with the clinical requirements. Validation of the proposed OA temperature imaging technique was performed for slow and fast cooling of blood samples embedded in tissue-mimicking phantoms.

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Long-Term Cancer-Specific and Overall Survival for Men Followed More Than 10 Years After Primary and Salvage Cryoablation of the Prostate

Abstract: The long-term results of prostate cryotherapy in our series indicate an 87% overall 10-year prostate-cancer-specific survival, despite early cryotherapy technology and the majority of patients being D'Amico high risk.

Cited by 42 publications

References 28 publications

Prostate Cancer Risk in Pre-Diabetic Men: A Matched Cohort Study

Prostate Cancer Risk in Pre-Diabetic Men: A Matched Cohort Study

Third-Generation Salvage Cryotherapy for Radiorecurrent Prostate Cancer: A Centre’s Experience

Imaging technique for real-time temperature monitoring during cryotherapy of lesions

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